nr0b1
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  • Official Full Name
  • nuclear receptor subfamily 0, group B, member 1
  • Background
  • This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
  • Synonyms
  • NR0B1; nuclear receptor subfamily 0, group B, member 1; AHC, dosage sensitive sex reversal , DSS; nuclear receptor subfamily 0 group B member 1; AHCH; DAX1; nuclear receptor DAX1; nuclear receptor DAX-1; nuclear hormone receptor; DSS-AHC critical region
Cat.#:NR0B1-6064HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NR0B1 Protein, GST-tagged
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Cat.#:NR0B1-11833HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR0B1, His-tagged
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Cat.#:Nr0b1-1094MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nr0b1 protein, His & T7-tagged
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Cat.#:Nr0b1-1095RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nr0b1 protein, His & T7-tagged
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Cat.#:NR0B1-4060RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NR0B1 Protein
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Cat.#:NR0B1-3091RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NR0B1 Protein, His-tagged
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Cat.#:NR0B1-6162CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NR0B1
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Cat.#:NR0B1-5308ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NR0B1
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Cat.#:NR0B1-3723HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NR0B1 293 Cell Lysate
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Involved Pathway

NR0B1 involved in several pathways and played different roles in them. We selected most pathways NR0B1 participated on our site, such as Gene Expression, Generic Transcription Pathway, Nuclear Receptor transcription pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR0B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Gene Expression
CSTF1; POLRMT; SNAPC1; NRBF2; SKIA; SF3A1; TRMT1; NR0B2A; DDX20; NR5A1B
Generic Transcription Pathway
ESRRA; ZNF688; ZNF264; TEAD3B; ZNF398; ZNF726; ZIM3; ZNF155; CTGF; GLS2B
Nuclear Receptor transcription pathway
ESRRGA; RARAA; ESRRG; NR2F6A; NRBF2; NR2F1B; PPARAA; NR0B1; ESR2B; NR5A1B
Nuclear Receptors
ROR1; VDRB; RARGB; NR1D2; NR2E1; NR1I3; RARGA; NR2F1A; NR2F1; NR0B1
Regulation of Androgen receptor activity
SMARCE1; KAT7; TRIM24; NR2C1; GATA2; HOXB13; SMARCA2; APPBP2; NR2C2; NR0B1

Protein Function

NR0B1 has several biochemical functions, for example, AF-2 domain binding, DNA binding, DNA hairpin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR0B1 itself. We selected most functions NR0B1 had, and list some proteins which have the same functions with NR0B1. You can find most of the proteins on our site.
Function
Related Protein
Function AF-2 domain binding
Related Protein PPARGC1B; ESRRG; NR0B1
Function DNA binding
Related Protein ZNF501; ANO9A; KDM5BA; SIX1A; NEUROD6B; EPAS1; RYBP; TERFA; NCOR2; NR2F6B
Function DNA hairpin binding
Related Protein NR0B1
Function RNA binding
Related Protein DDX59; RPL38; RPL31; CPSF3; BAZ2A; RPL5; PAPOLB; PUS3; KHDC3; HNRNPA0
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein NR1H4; NR1H3; ESRRA; STAT3; RORAB; RORC; NR2F2; NR5A2; PPARDB; NR4A2B
Function protein binding
Related Protein PAN3; MICALL1; ZFP932; KRT7; ZNF785; EGF; ITGAX; POLR3C; ALCAM; STX19
Function protein domain specific binding
Related Protein PRKAR2B; RQCD1; TUBA1A; ARFIP1; NCK1; ZBTB16; TWIST2; CSNK2B; KPNB1; VRK2
Function protein homodimerization activity
Related Protein LRP4; SETMAR; ZBTB1; ADRA2C; GRPEL2; UGT1A2; XPA; IKZF3; GDNF; TOP2A
Function sequence-specific DNA binding
Related Protein TSNAX; IRX5B; FOXF2; ZNF238; FOXQ1B; HOXC9; MNX2A; PBX3B; IRF4; ZKSCAN14
Function steroid hormone receptor activity
Related Protein NR1H5; RARGB; ESR1; NR4A2; NR2F1B; NR2E1; PAQR8; RXRGA; HNF4A; NR5A1B
Function steroid hormone receptor binding
Related Protein NR0B1
Function transcription corepressor activity
Related Protein HEYL; ID4; TBL1X; HDAC7A; ZMYND11; MECP2; KCNA3; E2F6; NOC2L; KLF12
Function transcription factor binding
Related Protein PIANP; MLXIPL; ATOH8; DRG1; PAX6; HIF1A; PRICKLE1; E2F5; SMAD2; HMGA1-RS1

Interacting Protein

NR0B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR0B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR0B1.
ESRRG; NR5A1; RORA