NR0B1 Protein, nuclear receptor subfamily 0, group B, member 1


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Official Full Name nuclear receptor subfamily 0, group B, member 1
Background This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
Synonyms NR0B1; nuclear receptor subfamily 0, group B, member 1; AHC, dosage sensitive sex reversal , DSS; nuclear receptor subfamily 0 group B member 1; AHCH; DAX1; nuclear receptor DAX1; nuclear receptor DAX-1; nuclear hormone receptor; DSS-AHC critical region
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Nr0b1-556M Recombinant Mouse Nr0b1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human NR0B1-11833H Recombinant Human NR0B1, His-tagged E.coli His
    Human NR0B1-3723HCL Recombinant Human NR0B1 293 Cell Lysate HEK293 N/A
    Human NR0B1-6064H Recombinant Human NR0B1 Protein, GST-tagged Wheat Germ GST
    Mouse Nr0b1-1094M Recombinant Mouse Nr0b1 protein, His & T7-tagged E.coli His/T7
    Rat Nr0b1-1095R Recombinant Rat Nr0b1 protein, His & T7-tagged E.coli His/T7
    Rat NR0B1-4060R Recombinant Rat NR0B1 Protein Mammalian Cell His
    Rhesus Macaque NR0B1-3091R Recombinant Rhesus monkey NR0B1 Protein, His-tagged Mammalian Cell His
    Chicken NR0B1-6162C Recombinant Chicken NR0B1 Mammalian Cell His
    Zebrafish NR0B1-5308Z Recombinant Zebrafish NR0B1 Mammalian Cell His

    NR0B1 involved in several pathways and played different roles in them. We selected most pathways NR0B1 participated on our site, such as Gene Expression, Generic Transcription Pathway, Nuclear Receptor transcription pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR0B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gene Expression MTA1; ZNF613; HUG; CCAR1; ZNF433; ZNF274; ZNF839; SAP30BP; MAPKAPK2B; ZNF785
    Generic Transcription Pathway Txn1; NR2F1B; ZNF189; ZNF354B; ZNF350; ZNF213; ESRRGA; ZNF556; ZNF621; LAMTOR1
    Nuclear Receptor transcription pathway ESR2B; NR5A1; NR2F1; RARGA; RORAA; NR2E3; NR6A1; NR0B1; RARAA; NR5A1B
    Nuclear Receptors NR2F1A; NR2F2; VDRB; NR1D2B; NR5A1; NR2C2; NR1H3; NR2F6; NR1I2; RARG
    Regulation of Androgen receptor activity TRIM24; HOXB13; SMARCE1; APPBP2; NR2C1; SENP1; NR0B1; KAT7; SRY; SMARCA2

    NR0B1 has several biochemical functions, for example, AF-2 domain binding, DNA binding, DNA hairpin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR0B1 itself. We selected most functions NR0B1 had, and list some proteins which have the same functions with NR0B1. You can find most of the proteins on our site.

    Function Related Protein
    AF-2 domain binding ESRRG; PPARGC1B; NR0B1
    DNA hairpin binding NR0B1
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding NR4A2A; NR5A2; NR2F2; RXRA; NR2F6B; RORB; NR2F6A; NR2F1B; NR2F1A; PTGER3
    protein binding ZFYVE20; UBC; CAMTA2; MC5R; PSMA5; CD1B; BCOR; MOCS3; BLVRA; O3far1
    protein domain specific binding YWHAG1; HIST1H4D; CBX3; KCNN2; DRD3; KCTD13; YWHABA; HIST1H4J; TJP2; NLRP1
    protein homodimerization activity HPRT1; ZNF174; ARID3A; PAH; MTUS2; ATP2A1; HAND1; ANXA9; TFAP2B; VOX
    sequence-specific DNA binding RARAB; ZNF75D; ARX; POU3F2B; ZNF711; FOXJ3; PPARGC1A; ZBTB4; BACH1A; TFAP4
    steroid hormone receptor activity VDRA; NR2F6; OLFR78; RORAA; ESR2B; GPR30; NR1H3; NR2F6B; ESR2A; PAQR7A
    steroid hormone receptor binding NR0B1
    transcription corepressor activity ATN1; TMEM38A; CTBP2A; YAF2; APEX1; YWHAB; TOB1; AEBP2; WTIP; MXD1
    transcription factor binding IGHMBP2; HES3; DDIT3; NFKB1; PIM1; HES4; UBE2I; RBFOX2; APBB3; FOXA1

    NR0B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR0B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR0B1.


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