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NR1D2

  • Official Full Name

    nuclear receptor subfamily 1, group D, member 2

  • Overview

    This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described.
  • Synonyms

    NR1D2; nuclear receptor subfamily 1, group D, member 2; nuclear receptor subfamily 1 group D member 2; BD73; EAR 1r; Hs.37288; HZF2; RVR; EAR-1R; NR1D2_HUMAN; Orphan nuclear hormone receptor BD73; Rev erb beta; Rev-erb-beta; REVB; REVERBB; V-erbA-related protein 1-related; OTTHUMP00000208397; rev-erba-alpha-related receptor; nuclear receptor Rev-ErbA beta variant 1; nuclear receptor Rev-ErbA beta var;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His|GST
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NRID2-1150H Active Recombinant Human Nuclear R eceptor Subfamily 1, Group D, Member 2 Sf9 Insect Cell N/A
Human NR1D2-30452TH Recombinant Human NR1D2 N/A
Human NR1D2-8488H Recombinant Human NR1D2, His-tagged Sf21 Insect Cell His
Human NR1D2-3721HCL Recombinant Human NR1D2 293 Cell Lysate HEK293 N/A
Human NR1D2-2532H Recombinant Human NR1D2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human NR1D2-6068H Recombinant Human NR1D2 Protein, GST-tagged Wheat Germ GST
Human NR1D2-6693HF Recombinant Full Length Human NR1D2 Protein, GST-tagged In Vitro Cell Free System GST 579 amino acids
Mouse Nr1d2-4484M Recombinant Mouse Nr1d2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Nr1d2-1082R Recombinant Rat Nr1d2 protein, His & GST-tagged E.coli His/GST Lys249~Pro578 (Accession # Q63504)
Chicken NR1D2-6758C Recombinant Chicken NR1D2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NR1D2 Related Articles

NR1D2 involved in several pathways and played different roles in them. We selected most pathways NR1D2 participated on our site, such as Diurnally regulated genes with circadian orthologs, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR1D2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Diurnally regulated genes with circadian orthologsDAZAP2;ZFR;ERC2;RBPMS;KLF9;GFRA1;PURA;SF3A3;CBX3
Gene ExpressionTEAD1A;DDX6;EIF2S3;POP1;SPCS3;ZNF549;GTF3AA;ZNF556;COX5B
Generic Transcription PathwaySKIB;LRPPRC;ZNF671;NR2F1B;ZNF658;ZNF333;NR2F6B;ZNF12;MED10
Nuclear Receptor transcription pathwayNR2F6B;RXRBB;NR5A1A;NR5A1B;NR1D2B;NR2F1B;ESR2A;NR4A2B;NR2F6
Nuclear ReceptorsNR2E1;NR5A1;RARGA;NR1H3;NR1D2;RARGB;NR2F1;VDRB;NR2F6

NR1D2 has several biochemical functions, for example, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding, core promoter sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR1D2 itself. We selected most functions NR1D2 had, and list some proteins which have the same functions with NR1D2. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingSTAT3;RXRA;NR5A5;RORCB;NR2F6A;NR4A2;NR5A1;VDRA;NR2F6B
core promoter sequence-specific DNA bindingTRP53;SIRT1;ZNF750;NFYA;KLF10;RORA;C1orf51;NRIP1;NRF1
protein bindingTBC1D5;SLC39A7;GPR85;KLRC1;AVPR1A;CTF1;MYH11;ZFP161;ARL13B
steroid hormone receptor activityVDR;ESR2B;RORA;RXRB;RXRGA;OR51E2;RARG;PPARA;RORCB
zinc ion bindingPRICKLE2B;NHLRC1;BSPRY;KLF7;CA4;RBM10;CALB1;UHRF1;FHL5

NR1D2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR1D2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR1D2.

Clock; PRMT6; BHLHE40; CSNK2A2; RORC; Cry1; Csnk1e

Lazado, CC; Kumaratunga, HPS; et al. In vitro and ex vivo models indicate that the molecular clock in fast skeletal muscle of Atlantic cod is not autonomous. MOLECULAR BIOLOGY REPORTS 41:6679-6689(2014).
Lazado, CC; Kumaratunga, HPS; et al. Daily Rhythmicity of Clock Gene Transcripts in Atlantic Cod Fast Skeletal Muscle. PLOS ONE 9:-(2014).
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