nr1d2
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  • Official Full Name
  • nuclear receptor subfamily 1, group D, member 2
  • Background
  • This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described.
  • Synonyms
  • NR1D2; nuclear receptor subfamily 1, group D, member 2; nuclear receptor subfamily 1 group D member 2; BD73; EAR 1r; Hs.37288; HZF2; RVR; EAR-1R; NR1D2_HUMAN; Orphan nuclear hormone receptor BD73; Rev erb beta; Rev-erb-beta; REVB; REVERBB; V-erbA-related protein 1-related; OTTHUMP00000208397; rev-erba-alpha-related receptor; nuclear receptor Rev-ErbA beta variant 1; nuclear receptor Rev-ErbA beta var
Cat.#:NR1D2-6068HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NR1D2 Protein, GST-tagged
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Cat.#:NRID2-1150HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Nuclear R eceptor Subfamily 1, Group D, Member 2
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Cat.#:NR1D2-30452THTag:
Source (Host):Species:Human
Product nameRecombinant Human NR1D2
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Cat.#:NR1D2-8488HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human NR1D2, His-tagged
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Cat.#:Nr1d2-1082RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nr1d2 protein, His & GST-tagged
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Cat.#:NR1D2-6758CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NR1D2
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Cat.#:NR1D2-3721HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NR1D2 293 Cell Lysate
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Involved Pathway

NR1D2 involved in several pathways and played different roles in them. We selected most pathways NR1D2 participated on our site, such as Diurnally regulated genes with circadian orthologs, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR1D2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Diurnally regulated genes with circadian orthologs
NR1D2; UCP3; CEBPB; EIF4G2; TOB1; GFRA1; CRY2; DAZAP2; SF3A3; KLF9
Gene Expression
PTRFB; BAZ2A; JARID2; DPY19L2; HNRNPH2; ZNF202; SESN3; SETA; NR2C2AP; ZNF224
Generic Transcription Pathway
MED25; ZKSCAN1; SKILB; ZNF253; ZNF747; ZNF454; ZNF471; NR2F6B; ZNF446; RRAGA
Nuclear Receptor transcription pathway
NR2F1B; RARG; NR4A2A; NR1I2; NR5A1A; NR0B2A; NR2F6; NR1D2; NR2F1A; NR2C2AP
Nuclear Receptors
NR2C2; NR2E1; ROR1; NR1D2; RORAA; NR5A1; RARG; VDRB; NR1I3; NR2F2

Protein Function

NR1D2 has several biochemical functions, for example, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding, core promoter sequence-specific DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR1D2 itself. We selected most functions NR1D2 had, and list some proteins which have the same functions with NR1D2. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein NR5A1; ESRRA; PPARA; PPARD; HNF4G; RORB; RXRA; PPARAA; NR4A1; NR2F6
Function core promoter sequence-specific DNA binding
Related Protein ESR2; CHD2; C1orf51; THRAP3; KLF10; SOHLH2; MEOX1; RORA; CRY1; ZNF750
Function protein binding
Related Protein MYO5A; CD24; TOPORS; SLC26A6; C9orf142; ZNF83; SLC22A6; TRIM22; SMOC1; FAM86A
Function steroid hormone receptor activity
Related Protein NR2F6; NR1H3; HNF4G; PPARA; ESRRGB; PPARG; NR3C2; OR51E2; ESR2; ESRRA
Function zinc ion binding
Related Protein ENPP2; MUL1; MYT1LA; RNF34A; RNF130; GATAD2AB; BPTF; DNAJC24; RNF40; TRIM42

Interacting Protein

NR1D2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR1D2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR1D2.
Clock; PRMT6; BHLHE40; CSNK2A2; RORC; Cry1; Csnk1e

NR1D2 Related Articles

Lazado, CC; Kumaratunga, HPS; et al. In vitro and ex vivo models indicate that the molecular clock in fast skeletal muscle of Atlantic cod is not autonomous. MOLECULAR BIOLOGY REPORTS 41:6679-6689(2014).
Lazado, CC; Kumaratunga, HPS; et al. Daily Rhythmicity of Clock Gene Transcripts in Atlantic Cod Fast Skeletal Muscle. PLOS ONE 9:-(2014).