nr5a2
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  • Official Full Name
  • NR5A2 nuclear receptor subfamily 5, group A, member 2
  • Background
  • Liver receptor homolog-1 (LRH-1), also known as NR5A2, is a member of the orphan nuclear receptor family. It has been linked to a variety of processes, such as bile acid metabolism, reverse cholesterol transport, cell proliferation in the developing pancreas, and steroidogenesis.
  • Synonyms
  • NR5A2; nuclear receptor subfamily 5, group A, member 2; FTF; nuclear receptor subfamily 5 group A member 2; B1F2; FTZ F1; FTZ F1beta; hB1F; hB1F 2; liver receptor homolog 1; LRH 1; nuclear receptor NR5A2; liver receptor homolog-1; CYP7A promoter-binding factor; hepatocytic transcription factor; alpha-1-fetoprotein transcription factor; liver nuclear receptor homolog-1 variant 2; fetoprotein-alpha 1 (AFP) transcription factor; b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus; B1F; CPF; LRH1; LRH-1; FTZ-F1; hB1F-2; FTZ-F1beta;
Cat.#:NR5A2-6100HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NR5A2 Protein, GST-tagged
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Cat.#:NR5A2-1052HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human NR5A2
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Cat.#:NR5A2-1053HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR5A2, GST-tagged
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Cat.#:NR5A2-1092HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR5A2 protein, His-tagged
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Cat.#:Nr5a2-1093RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nr5a2 protein, His & T7-tagged
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Cat.#:NR5A2-4074RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NR5A2 Protein
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Cat.#:NR5A2-6635CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken NR5A2
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Cat.#:NR5A2-9030ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NR5A2
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Involved Pathway

NR5A2 involved in several pathways and played different roles in them. We selected most pathways NR5A2 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR5A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Maturity onset diabetes of the young
MNX1; IAPP; SLC2A2; NEUROD1; PAX4; NEUROG3; HNF1A; PKLR; NR5A2; BHLHA15

Protein Function

NR5A2 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR5A2 itself. We selected most functions NR5A2 had, and list some proteins which have the same functions with NR5A2. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein FOXP1A; TBX3A; ZNF7; GSX1; SUB1B; ZNF227; NR6A1A; HMGB2A; PC; HNRPK
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein MYOD1; MIXL1; RFX2; PRDM5; SIX4; HLTF; CEBPG; ETS2; NFE2L3; NR4A3
Function RNA polymerase II distal enhancer sequence-specific DNA binding
Related Protein PAX4; CREB1; TFAP2C; NR5A1; MSC; NFKB1; NFATC1; NFE2L1; SFPQ; FLI1
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein NR2F6A; STAT3; ESRRB; VDRA; NR2F6B; RORB; NR1H2; PTGER3; NR5A1B; NR2F5
Function chromatin binding
Related Protein PRKCBP1L; SMC1A; C19orf40; TDRD3; ATXN7; TCF7; SAFB; TFAP2A; CBX4; MAZ
Function phospholipid binding
Related Protein NSFL1C; PACSIN1A; APOM; MYOF; WDFY4; ABCA1; ARHGAP44; DAPP1; BAD; OTC
Function protein binding
Related Protein NUP35; KEL; PSMB5; KLF12; PTBP3; KRT6A; CEP76; RBM15; RUNDC3A; GOLPH3L
Function sequence-specific DNA binding
Related Protein FOXR1; ZNF500; NOTCH1; TLX3B; RORAA; POU3F2B; NR0B1; HSF5; FOXQ1A; IKZF4
Function steroid hormone receptor activity
Related Protein NR1D2; NR4A2A; PPARAA; NR1D2B; ESR2B; NR2F1A; NR2F2; NR2F6B; RORAA; NR1D4A
Function transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
Related Protein NKX2; NFIX; SRF; MEF2C; PROX1; RFX3; POU4F1; GTF2IRD1; MITF; SFPI1
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZFP110; LHX1; HOXB6A; HOXC6A; CREB1; ZNF74; JUNBB; MNX1; IRF1A; CREB3L3A
Function transcription regulatory region DNA binding
Related Protein CDK5RAP2; YY1; WNT11; H2AFY; TAF7L; HINFP; ZFP382; SOX17; IKZF4; DHX36
Function transcription regulatory region sequence-specific DNA binding
Related Protein SUV39H2; MEF2CA; KDM3A; DDIT3; NR5A2; CREB3L3; FOXN1; HIF1AL; NR5A1B; BTBD8
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein STAT3; EPAS1; CRX; BCL11B; TRP53; NR6A1; ATOH1; TFE3B; E2F4; KLF15
Function zinc ion binding
Related Protein ZCCHC6; TRIM17; ZFAND6; TRIM55A; LIMD2; ADAM2; RNF20; RNF212; ADAM28; GATA2A

Interacting Protein

NR5A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR5A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR5A2.
UBE2I; EDF1; PROX1