nxf1
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  • Official Full Name
  • nuclear RNA export factor 1
  • Background
  • This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • NXF1; nuclear RNA export factor 1; DKFZp667O0311; Mex67; TAP; tip associating protein; mRNA export factor TAP; tip-associated protein; tip-associating protein
Cat.#:Nxf1-406RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nxf1 Protein, His-tagged
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Cat.#:NXF1-1427HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NXF1, GST-tagged
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Cat.#:NXF1-11014MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NXF1 Protein
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Cat.#:NXF1-4135RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NXF1 Protein
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Cat.#:NXF1-3622HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human NXF1 293 Cell Lysate
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Involved Pathway

NXF1 involved in several pathways and played different roles in them. We selected most pathways NXF1 participated on our site, such as Gene Expression, Herpes simplex infection, Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with NXF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Gene Expression
NFIX; NR2F6A; MBD3; ZIM3; ZNF658; PTRF; ZNF215; TYW3; NR4A2B; ZNF274
Herpes simplex infection
SKP1; TLR2-2; TAP1; POLR2A; HLA-DQA2; TAF6; IFNA2; TAF3; IFNA4; HLA-DMB
Influenza A
DDX58; IFNB; Ifna15; IL6; HLA-DRA; TNFRSF10A; EIF2AK3; IL8L1; PIK3CA; MAP2K4
Processing of Capped Intron-Containing Pre-mRNA
HNRNPL2; PDCD7; SF3B2; TXNL4A; HNRNPA0L; YBX1; ZCRB1; HNRNPH2; BCAS2; SF3A1
RNA transport
NCBP2; RPP14; EEF1A1B; EEF1A2; CLNS1A; NUP205; TPR; EIF4EA; PABPC1A; EEF1A1L1
Ribosome biogenesis in eukaryotes
NHP2L1A; LOC81691; RPP30; POP4; RAN; CIRH1A; NAT10; NHP2; MPHOSPH10; cka1
Transport of Mature Transcript to Cytoplasm
SLBP; NXF1; U2AF2; SRSF11; SFRS3A
Transport of Mature mRNA Derived from an Intronless Transcript
NXF1

Protein Function

NXF1 has several biochemical functions, for example, nucleotide binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NXF1 itself. We selected most functions NXF1 had, and list some proteins which have the same functions with NXF1. You can find most of the proteins on our site.
Function
Related Protein
Function nucleotide binding
Related Protein ABCA5; RBPMS2A; ABCA13; SRSF1A; ABCB6A; RBM4.1; EIF4H; IGF2BP1; MXB; OXSR1A
Function poly(A) RNA binding
Related Protein HIST1H4C; RPS17L; ENO1; HADHB; HIST1H4H; PSMC1; MRPS26; TBCA; HNRNPK; LAS1L
Function protein binding
Related Protein PIK3R3; TFIP11; BBOX1; NCAPH; TRAPPC5; STARD3; CCL11; NKX2-1; MAPKAPK5; PDCD2
Function single-stranded RNA binding
Related Protein LSM14A; CNBP; ZFP36; TLR7; PIWIL1; DDX58; ANXA1; JMJD6; LONP1; A1CF

Interacting Protein

NXF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NXF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NXF1.
NUP62; NXT1; NUP153; SRSF1