Nme8 Protein, NME/NM23 family member 8


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Official Full Name NME/NM23 family member 8
Background This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in this gene are implicated in primary ciliary dyskinesia type 6
Synonyms TXNDC3; thioredoxin domain containing 3 (spermatozoa); thioredoxin domain-containing protein 3; CILD6; NME8; sperm specific thioredoxin 2; SPTRX2; CILD6; NM23 H8; NME8; Sperm specific thioredoxin 2; Spermatid specific thioredoxin 2; Sptrx 2; SPTRX2; Thioredoxin domain containing protein 3; sperm-specific thioredoxin 2; spermatid-specific thioredoxin-2; NM23-H8; sptrx-2; NME/NM23 family member 8
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NME8-1164H Recombinant Human NME8 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human NME8-793H Recombinant Human NME8 Mammalian Cell His
    Mouse NME8-10745M Recombinant Mouse NME8 Protein Mammalian Cell His
    Zebrafish NME8-5581Z Recombinant Zebrafish NME8 Mammalian Cell His

    Nme8 involved in several pathways and played different roles in them. We selected most pathways Nme8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Nme8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    Nme8 has several biochemical functions, for example, microtubule binding, nucleoside diphosphate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Nme8 itself. We selected most functions Nme8 had, and list some proteins which have the same functions with Nme8. You can find most of the proteins on our site.

    Function Related Protein
    microtubule binding KIF19; PRC1B; MAPRE1A; KRIT1; KIF22; PEX14; KLC3; ZFP207; KIF9; MAPRE3A
    nucleoside diphosphate kinase activity NME5; NME3; TXNDC3; NME1; AK4; NME2B.1; AK5; CMPK; AK8; NME6

    Nme8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Nme8 here. Most of them are supplied by our site. Hope this information will be useful for your research of Nme8.

    Karch, CM; Goate, AM; et al. Alzheimer's Disease Risk Genes and Mechanisms of Disease Pathogenesis. BIOLOGICAL PSYCHIATRY 77:43-51(2015).
    Liu, Y; Yu, JT; et al. Association between NME8 Locus Polymorphism and Cognitive Decline, Cerebrospinal Fluid and Neuroimaging Biomarkers in Alzheimer's Disease. PLOS ONE 9:-(2014).

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