oas3
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  • Official Full Name
  • 2-5-oligoadenylate synthetase 3, 100kDa
  • Background
  • This gene encodes an enzyme included in the 2, 5 oligoadenylate synthase family.This enzyme is induced by interferons and catalyzes the 2, 5 oligomers of adenosine in order to bind and activate RNase L.This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance.
  • Synonyms
  • OAS3; 2-5-oligoadenylate synthetase 3, 100kDa; 2 5 oligoadenylate synthetase 3 (100 kD); 2-5-oligoadenylate synthase 3; p100OAS; p100 OAS; 2-5A synthase 3; 2-5A synthetase 3; (2-5)oligo(A) synthase 3; (2-5)oligo(A) synthetase 3; 2-5oligoadenylate syntheta
Cat.#:OAS3-1434HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human OAS3, GST-tagged
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Cat.#:OAS3-11043MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse OAS3 Protein
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Cat.#:OAS3-4145RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat OAS3 Protein
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Cat.#:OAS3-3613HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human OAS3 293 Cell Lysate
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Involved Pathway

OAS3 involved in several pathways and played different roles in them. We selected most pathways OAS3 participated on our site, such as Hepatitis C, Measles, Influenza A, which may be useful for your reference. Also, other proteins which involved in the same pathway with OAS3 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Hepatitis C
BAD; IKBKB; OAS1A; CLDN16; IFNA14; IFNB1; IFNA16; MAPK9; NFKBIA; RELA
Measles
RAB9A; IFNA17; FCGR2B; CD3E; DOK1; STAT5B; IL2RB; FAS; Ifna15; CCND3
Influenza A
IKBKB; IFNA21; TLR3; FURIN; IFNA13; BMA1; IFNA8; MYD88; MAP2K1; MAPK13
Herpes simplex infection
CUL1; EIF2AK4; HLA-DRB3; MAPK8; ARNTL1A; BF1; IFNA6; CUL1A; TAF5; IRF3

Protein Function

OAS3 has several biochemical functions, for example, 2-5-oligoadenylate synthetase activity, ATP binding, double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OAS3 itself. We selected most functions OAS3 had, and list some proteins which have the same functions with OAS3. You can find most of the proteins on our site.
Function
Related Protein
Function 2-5-oligoadenylate synthetase activity
Related Protein OAS1; OASL2; OAS2; OAS1A; OAS3
Function ATP binding
Related Protein EP400; LONP1; CLCN6; TTK; CDKL4; CLPX; PMVK; TNK1; KIF22; NTPCR
Function double-stranded RNA binding
Related Protein SLC3A2; AGO2; VIM; ILF3; DROSHA; LRRFIP1; PRKRIP1; EIF2C3; TLR8; MSN
Function metal ion binding
Related Protein DMRTA2; ARSE; NTHL1; STAMBPA; ZFY2; ZNF19; TRIM8A; ZNF649; GART; HIC2
Function protein binding
Related Protein IFT88; MFAP4; MAP4K1; WASF2; DAPP1; NR0B1; ARNTL; FBXO18; CARD8; ZFYVE21

Interacting Protein

OAS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OAS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of OAS3.
EIF6; IFRD2; DHX30; MAVS; FTSJ3; PPM1G; CCDC22; TOP1; HIST1H1C; PABPC4; Eea1; ZNF622; GNL3; GTPBP4; LYAR