ophn1
Share
  • Official Full Name
  • oligophrenin 1
  • Background
  • This gene encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Rho proteins are important mediators of intracellular signal transduction, which affects cell migration and cell morphogenesis. Mutations in this gene are responsible for OPHN1-related X-linked mental retardation with cerebellar hypoplasia and distinctive facial dysmorhphism.
  • Synonyms
  • OPHN1; oligophrenin 1; mental retardation, X linked 60 , MRX60; oligophrenin-1; ARHGAP41; OPN1; OTTHUMP00000023451; mental retardation, X-linked 60; oligophrenin-1, Rho-GTPase activating protein; MRX60
Cat.#:OPHN1-297HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human OPHN1 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:Ophn1-8001MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ophn1 protein, His & T7-tagged
+Inquiry
Cat.#:OPHN1-4189RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat OPHN1 Protein
+Inquiry
Cat.#:Ophn1-8002RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ophn1 protein, His & T7-tagged
+Inquiry
Cat.#:OPHN1-3169RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey OPHN1 Protein, His-tagged
+Inquiry
Cat.#:OPHN1-811ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish OPHN1
+Inquiry

Involved Pathway

OPHN1 involved in several pathways and played different roles in them. We selected most pathways OPHN1 participated on our site, such as Rho GTPase cycle, Signal Transduction, Signaling by Rho GTPases, which may be useful for your reference. Also, other proteins which involved in the same pathway with OPHN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Rho GTPase cycle
ARHGAP26; ARHGAP12B; ABR; ARHGAP4A; ARHGAP22; ARHGAP25; ARHGAP44; ARHGAP17B; NET1; TAGAPA
Signal Transduction
FGD4A; VIP; FGFBP3; FABP11A; OTULINB; RHOF; PLEKHG2; BOC; CNR2; PRICKLE1B
Signaling by Rho GTPases
ARHGAP9; GMIP; LIN7B; ARHGAP32; ARHGAP26; ARHGEF16; ARHGAP10; ARHGAP29B; MKL1B; ARHGAP33

Protein Function

OPHN1 has several biochemical functions, for example, GTPase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by OPHN1 itself. We selected most functions OPHN1 had, and list some proteins which have the same functions with OPHN1. You can find most of the proteins on our site.
Function
Related Protein
Function GTPase activator activity
Related Protein RAB3GAP2; ARHGEF6; RP2; ELMOD2; ARFGAP2; AXIN2; RABGAP1L; TBC1D20; AGAP1; RAB3GAP1