p2ry6
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  • Official Full Name
  • pyrimidinergic receptor P2Y, G-protein coupled, 6
  • Background
  • The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. Four transcript variants encoding the same isoform have been identified for this gene.
  • Synonyms
  • P2RY6; pyrimidinergic receptor P2Y, G-protein coupled, 6; P2Y purinoceptor 6; P2Y6; G coupled nucleotide receptor; G protein coupled 6; MGC15335; P2 purinoceptor; P2RY6_HUMAN; P2Y6 receptor; PP2891; Purinergic receptor P2Y6; pyrimidinergic receptor P2Y; OTTHUMP00000237497; OTTHUMP00000237500; OTTHUMP00000237501; OTTHUMP00000237502; OTTHUMP00000237504; OTTHUMP00000237505; OTTHUMP00000237506; G-coupled nucleotide receptor
Cat.#:P2RY6-30535THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human P2RY6
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Cat.#:P2RY6-4239RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat P2RY6 Protein
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Cat.#:P2RY6-6749CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken P2RY6
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Cat.#:P2RY6-3484HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human P2RY6 293 Cell Lysate
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Cat.#:P2RY6-3485HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human P2RY6 293 Cell Lysate
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Cat.#:Kit-1475Tag:
Source (Host):Species:
Product nameP2RY6 CHO-K1 β-Arrestin GPCR Assay Kit
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Cat.#:Kit-0967Tag:
Source (Host):Species:
Product nameTR-FRET RAR beta Coactivator Assay Kit, goat
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Cat.#:CSC-RG0380Tag:
Source (Host):Species:Human
Product nameHuman P2RY6-FLAG Stable Cell Line-1321N1
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Cat.#:CSC-RG0917Tag:
Source (Host):Species:Human
Product nameHuman P2RY6 Stable Cell Line-1321N1 astrocytoma
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Cat.#:CSC-RG0918Tag:
Source (Host):Species:Human
Product nameHuman P2RY6 Stable Cell Line-1321N1 astrocytoma
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Involved Pathway

P2RY6 involved in several pathways and played different roles in them. We selected most pathways P2RY6 participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with P2RY6 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Neuroactive ligand-receptor interaction
IL12; GHRHRL; P2RY14; TAAR14D; TAAR12E; TAAR8A; KISS1RB; PARD3; DRD1B; LEPR

Protein Function

P2RY6 has several biochemical functions, for example, G-protein coupled purinergic nucleotide receptor activity, G-protein coupled receptor activity, UDP-activated nucleotide receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by P2RY6 itself. We selected most functions P2RY6 had, and list some proteins which have the same functions with P2RY6. You can find most of the proteins on our site.
Function
Related Protein
Function G-protein coupled purinergic nucleotide receptor activity
Related Protein P2RY8; P2RY14; P2RY10; P2RY2; GPR34B; P2RY11; P2RY4; P2RY13; P2RY6; PTAFR
Function G-protein coupled receptor activity
Related Protein GPR150; GNRHR3; OR4N4; OLFR688; PROKR1; OLFR186; GNRHR2; VMN2R116; LPAR2A; GPR176
Function UDP-activated nucleotide receptor activity
Related Protein P2RY6; P2RY14
Function protein binding
Related Protein SEMG1; RIPPLY2; TRAIP; FOXH1; RHO; RBM41; TMEM199; SRGAP2; MBP; ZNF69

Interacting Protein

P2RY6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P2RY6 here. Most of them are supplied by our site. Hope this information will be useful for your research of P2RY6.
PLSCR1; KRTAP10-7

P2RY6 Related Gene Family

GPCRs