pak4
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  • Official Full Name
  • p21 protein (Cdc42/Rac)-activated kinase 4
  • Background
  • Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN.
  • Synonyms
  • PAK4 + PAK5 + PAK6; PAK4; p21 protein (Cdc42/Rac)-activated kinase 4; p21(CDKN1A) activated kinase 4; serine/threonine-protein kinase PAK 4; PAK-4; p21-activated kinase 4; p21(CDKN1A)-activated kinase 4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs
Cat.#:PAK4-766HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAK4 Protein, His-tagged
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Cat.#:PAK4-105HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human P21 Protein-activated Kinase 4, His-tagged
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Cat.#:PAK4-380HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PAK4, GST-tagged, Active
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Cat.#:PAK4-723HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PAK4, GST-His
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Cat.#:PAK4-18HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAK4
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Cat.#:PAK4-30671THTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PAK4
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Cat.#:PAK4-69HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human PAK4 protein, Flag-tagged, Biotinylated
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Cat.#:PAK4-12321MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PAK4 Protein
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Cat.#:PAK4-439ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PAK4
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Cat.#:PAK4-1283HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human p21 Protein (Cdc42/Rac)-Activated Kinase 4, GST-tagged
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Cat.#:PAK4-3455HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PAK4 293 Cell Lysate
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Cat.#:PAK4-3456HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PAK4 293 Cell Lysate
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Involved Pathway

PAK4 involved in several pathways and played different roles in them. We selected most pathways PAK4 participated on our site, such as Activation of Rac, Axon guidance, CDC42 signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of Rac
PAK4
Axon guidance
ARPC2; NTN1A; SEMA6C; HBEGF; NCK2; AGRN; SPTA1; EFNA2A; EFNB3B; SEMA5A
CDC42 signaling events
CDC42BPA; BAIAP2; ARPC2; ARPC3; TNK2; ARPC5; ARPC4; CFL1; CTNNA1; ARPC1B
Developmental Biology
SCN3B; CFC1; SDCBP; CLTC; EFNA3B; PITPNA; COL6A3; SCN4A; EFNB2A; SCN3A
ErbB signaling pathway
ERBB4A; HBEGFA; HRASB; CDKN1BA; MAP2K2A; CBLC; PIK3CA; ERBB3A; TGFA; BTC
FGF signaling pathway
FGF24; SOX32; FGFRL1A; SP8A; JUNBA; EGR2A; BGLAP; SPRY2; PAK4; FGFRL1B
Focal Adhesion
SRC; CAV3; PDGFAB; BRAF; CDC42L; TNR; LAMB4; CCND2; PARVAA; MYLK4

Protein Function

PAK4 has several biochemical functions, for example, ATP binding, Rac GTPase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAK4 itself. We selected most functions PAK4 had, and list some proteins which have the same functions with PAK4. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MAP2K6; TOR1A; TBK1; ULK4; CAMK1D; UBE2NA; CHUK; P2RX5; NTRK3A; LIG3
Function Rac GTPase binding
Related Protein NOXA1; PAK3; PAK6; PAK4; PAK2A; PAK7; ARHGAP4; CAV1; ARFIP2; DOCK7
Function protein binding
Related Protein ZCCHC17; PHF8; KLF12; PCP4; SRMS; ZNF286A; HTR6; PPP3R1; TRMT61B; LRGUK
Function protein kinase activity
Related Protein TSSK1; ROCK2A; SGK2A; PAN3; CAMK1GB; NPR1A; GM711; PAK4; MKNK2B; ADRBK2
Function protein serine/threonine kinase activity
Related Protein SLKA; EIF2AK2; RPS6KA3A; MAP2K2A; LRRK1; PRKY; NUAK1; TSSK2; SGK2A; ROCK2

Interacting Protein

PAK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAK4.
YWHAZ; CDC42; YWHAG; YWHAB; TERF1; SRPK2; SRPK1; YWHAQ; SFN; LRRK1; ARHGEF2; DLST; GATAD2A

PAK4 Related Articles

Kesanakurti, D; Chetty, C; et al. Functional cooperativity by direct interaction between PAK4 and MMP-2 in the regulation of anoikis resistance, migration and invasion in glioma. CELL DEATH & DISEASE 3:-(2012).
Zhang, HJ; Siu, MKY; et al. Overexpressed PAK4 promotes proliferation, migration and invasion of choriocarcinoma. CARCINOGENESIS 32:765-771(2011).