|Official Full Name||poly (ADP-ribose) polymerase family, member 3|
|Background||The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified.|
|Synonyms||PARP3; poly (ADP-ribose) polymerase family, member 3; ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase) like 3 , ADPRTL3; poly [ADP-ribose] polymerase 3; ADPRT3; hPARP 3; IRT1; NAD+ ADP ribosyltransferase 3; pADPRT 3; poly(ADP ribose) polymerase|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
PARP3 involved in several pathways and played different roles in them. We selected most pathways PARP3 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Base excision repair||LIG1; MPG; POLL; PARP2; HMGB1B; HMGB1A; APEX2; MBD4; xthA; PARP4|
PARP3 has several biochemical functions, for example, NAD+ ADP-ribosyltransferase activity, catalytic activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PARP3 itself. We selected most functions PARP3 had, and list some proteins which have the same functions with PARP3. You can find most of the proteins on our site.
|NAD+ ADP-ribosyltransferase activity||ART3; PARP6; PARP12; GIG2E; PARP9; TNKS; GIG2K; CHAT1; GIG2O; SIRT4|
|catalytic activity||CWF19L1; PKMB; HOGA1; ACAA1A; HSD3B6; APOBEC2B; ACSL1B; ACSL1; DPYDB; SULF2B|
PARP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PARP3.
MTHFD2; RPA3; HIST2H2BE; HIST2H3D