| Official Full Name | parvin, beta |
| Background | This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. |
| Synonyms | PARVB; parvin, beta; beta-parvin; affixin; CGI 56; Beta parvin; OTTHUMP00000198195; OTTHUMP00000198196; OTTHUMP00000198197; CGI-56 |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
PARVB involved in several pathways and played different roles in them. We selected most pathways PARVB participated on our site, such as Cell junction organization, Cell-Cell communication, Cell-extracellular matrix interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARVB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell junction organization | CDH5; ANG; CLDN4; PVRL2L; CDH6; CLDN7; COL17A1A; CLDN20; CDH12; CDH13 |
| Cell-Cell communication | JUP; CDH5; ANG; KIRREL3; CDH13; CDH6; CDH4; CDH2; DSCAM; CADM2B |
| Cell-extracellular matrix interactions | RSU1; FBLIM1; ITGB1B.1; LIMS1; PARVB; FERMT2; TESK1 |
| Focal Adhesion | COL2A1B; AKT3A; PPP1R12C; PXNA; THBS4A; PIK3R5; TNR; ARHGAP5; PDPK1; ACTN3 |
| Regulation of cytoskeletal remodeling and cell spreading by IPP complex components | TESK1; LIMS1; PARVB; RSU1 |
PARVB has several biochemical functions, for example, actin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PARVB itself. We selected most functions PARVB had, and list some proteins which have the same functions with PARVB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin binding | EPB41L3; SNTA1; GCET2; ESPN; MICAL1; FLII; PHACTR4; MPRIP; DAAM1; SPTBN1 |
| protein binding | ACPL2; VPS53; C2orf50; HAT1; TSPO; TNFRSF12A; LAT2; COMMD7; PSMD6; TLR6 |
PARVB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARVB here. Most of them are supplied by our site. Hope this information will be useful for your research of PARVB.
ILK; Arhgef7; Arhgef6; STK4; SNW1; CDC5L; Ilk
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