pax6
Share
  • Official Full Name
  • paired box 6
  • Background
  • This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
  • Synonyms
  • PAX6; paired box 6; AN; AN2; MGDA; WAGR; D11S812E; paired box protein Pax-6; oculorhombin; aniridia type II protein; paired box homeotic gene-6
Cat.#:Pax6-764RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pax6 Protein, His-tagged
+Inquiry
Cat.#:PAX6-130HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAX6
+Inquiry
Cat.#:PAX6-134HTag:Arg
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAX6 protein, Arginine-tagged
+Inquiry
Cat.#:PAX6-148HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAX6 Protein, His-tagged
+Inquiry
Cat.#:PAX6-29055THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PAX6
+Inquiry
Cat.#:PAX6-4284RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PAX6 Protein
+Inquiry
Cat.#:PAX6-3312RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PAX6 Protein, His-tagged
+Inquiry
Cat.#:PAX6-6623CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PAX6
+Inquiry
Cat.#:PAX6-3415HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PAX6 293 Cell Lysate
+Inquiry

Involved Pathway

PAX6 involved in several pathways and played different roles in them. We selected most pathways PAX6 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAX6 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Signaling pathways regulating pluripotency of stem cells
ID1; PIK3R1; ID2; FZD5; SMAD1; WNT3; HNF1A; WNT7A; FZD2; FGFR4
Maturity onset diabetes of the young
SLC2A2; IAPP; INS; HNF1A; RFX6; INS2; MNX1; PAX4; HHEX; INS1

Protein Function

PAX6 has several biochemical functions, for example, DNA binding, R-SMAD binding, RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAX6 itself. We selected most functions PAX6 had, and list some proteins which have the same functions with PAX6. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein HMGB2A; MBD1B; CREB1B; ZFP354A; ZNF711; TMPOB; SSH3; SOX3; DDB2; E2F7
Function R-SMAD binding
Related Protein PPM1A; MYOCD; SMURF1; JUN; PAX6; PARP1; AXIN1; FOS; ZEB2; MEN1
Function RNA polymerase II core promoter sequence-specific DNA binding
Related Protein EGR1; ZNF277; TP53; MAZ; H2AFY; SP1; SOX8; RUNX2; ZNF335; GATA6
Function RNA polymerase II transcription factor activity, sequence-specific DNA binding
Related Protein XBP1; FOXI2; LYL1; RELB; TAL2; FOXO3; FOXL1; FOXD4L1; SOX8; ZNF434
Function histone acetyltransferase binding
Related Protein TP53; MEF2A; KAT2B; EID1; TRIM68; TAF7L; CREB1; HIF1A; SIRT2; MTF1
Function protein binding
Related Protein SEC24A; POLDIP3; ARNTL2; IFIT2; CEP63; BAZ1A; PGAP2; HTRA3; SMNDC1; WRN
Function protein kinase binding
Related Protein PIH1D1; ATP1A1; ARHGEF7; STAT3; DPYSL2; TPCN2; SKAP1; APC; SYN1; TPX2
Function transcription factor activity, sequence-specific DNA binding
Related Protein FOXA1; PROX1; RBPJL; FUBP1; GM239; SPI1B; GABPA; GABPB1; TBX16; NR2F2
Function transcription factor binding
Related Protein CREG1; INSIG2; HDAC4; HDAC9; GATA2; PPARGC1A; HEYL; PYDC3; YWHAZ; ARID5A
Function ubiquitin-protein transferase activity
Related Protein UBE2L3; TRIM13; TRAF5; UBE2A; SKP1; FBXL5; BIRC5; TRIM21; ITCHA; TOPORS

Interacting Protein

PAX6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAX6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAX6.
Dlg4; IPO13; Dynll1; TRIM11; HOMER3; NKIRAS2; EPB41L2; PCNT; APOB; MARCKSL1; GMPS; UBE2M; RAN; TRAP1; UBE2V1

PAX6 Related Articles

Toriyama, A; Mori, T; et al. Utility of PAX8 mouse monoclonal antibody in the diagnosis of thyroid, thymic, pleural and lung tumours: a comparison with polyclonal PAX8 antibody. HISTOPATHOLOGY 65:465-472(2014).
Diaz-Balzac, CA; Vazquez-Figueroa, LD; et al. Novel markers identify nervous system components of the holothurian nervous system. INVERTEBRATE NEUROSCIENCE 14:113-125(2014).