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PC

  • Official Full Name

    pyruvate carboxylase

  • Overview

    Rabbit polyclonal antibodies in Dulbecco’s phosphate buffered saline, pH 7.2, with 1 mg/mL BSA. 0.05% sodium azide.
  • Synonyms

    PC; pyruvate carboxylase; pyruvate carboxylase, mitochondrial; PCB; pyruvic carboxylase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Human
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PC-908H Recombinant Human PC Mammalian Cell His
Human PC-1545H Recombinant Human PC, GST-tagged E.coli GST 828-1178aa
Human PC-3406HCL Recombinant Human PC 293 Cell Lysate HEK293 N/A
Human PC-4571H Recombinant Human PC Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PC-1561HFL Recombinant Full Length Human PC Protein, C-Flag-tagged Mammalian cells Flag
Human PC-760H Recombinant Human PC Protein, His-tagged E.coli His Pro36~Glu486
Human PC-1613H Recombinant Human PC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PC-2370H Recombinant Human PC Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PC-1613H-B Recombinant Human PC Protein Pre-coupled Magnetic Beads HEK293
Human PC-4804H Recombinant Human PC Protein (Pro36-Glu486), His tagged E.coli His Pro36-Glu486
Rat PC-4290R Recombinant Rat PC Protein Mammalian Cell His
Rat PC-3952R Recombinant Rat PC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PC-3952R-B Recombinant Rat PC Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PC-3315R Recombinant Rhesus monkey PC Protein, His-tagged Mammalian Cell His
Rhesus Macaque PC-3133R Recombinant Rhesus Macaque PC Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PC-3133R-B Recombinant Rhesus Macaque PC Protein Pre-coupled Magnetic Beads HEK293
Chicken PC-5918C Recombinant Chicken PC Mammalian Cell His
Kit-0662 Phosphatidylcholine Assay Kit N/A
Kit-0663 Phosphatidylcholine Colorimetric/Fluorometric Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PC Related Articles

PC involved in several pathways and played different roles in them. We selected most pathways PC participated on our site, such as Citrate cycle (TCA cycle), Pyruvate metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Citrate cycle (TCA cycle)IDH1;PDHB;DLD;SDHB;ACLY;DLAT;MDH2;IDH3A;FH1
Pyruvate metabolismMDH2;PKM;PKLR;MDH1AA;ACSS2L;LDHBB;GRHPRA;PDHA2;PDPR
Metabolic pathwaysPLA2G6;ACADL;NME2;MTMR3;GALNT12;SI;G6PC;FBP1B;POLR2I
Carbon metabolismENO1B;ACAT2;ackA;ALDOCA;FBP2;GPIA;PGAM1;GPR19;ENO1
Biosynthesis of amino acidsMAT2A;PRPS1;MTR;PKM2;TKTB;ENO1A;ACO2;BCAT2;CPS1

PC has several biochemical functions, for example, ATP binding, DNA binding, biotin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PC itself. We selected most functions PC had, and list some proteins which have the same functions with PC. You can find most of the proteins on our site.

Function Related Protein
ATP bindingP2RX1;NMRK2;PRKCH;PRKY;FIGN;ATP2A2A;C22orf28;PRKACBA;ERN1
DNA bindingSOX21;HIST1H111L;TADA2B;RFX2;HOXB13A;ZNF800;RAD50;BANF2;CHST13
biotin bindingMCCC1;PCCA;PCXB;PCXA;PC;HLCS;AVR2
biotin carboxylase activityPC;PCXB;PCXA;ACACB;ACACA;PCCA;MCCC1
metal ion bindingZNF584;KLK1B4;CYB561;ZFP553;DYTN;PPM1NB;HNRNPA0L;NR1D2A;ZBTB8A
protein bindingFBP2;ZBTB2;APEH;SUGP1;TDRKH;POLB;CCT3;F3;PLK4
pyruvate carboxylase activityPCXB;PCXA;PC

PC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PC here. Most of them are supplied by our site. Hope this information will be useful for your research of PC.

q03463-pro_0000278740; PPP2R2B; q99ib8-pro_0000045602; Ckap5; polg_hcvjf_rna; XRCC3; ERBB2; IFIT1; RAB7A; DYNLL1; Tubg1

Lokant, MT; Naz, RK; et al. Presence of PSA auto-antibodies in men with prostate abnormalities (prostate cancer/benign prostatic hyperplasia/prostatitis). ANDROLOGIA 47:328-332(2015).
Yang, HY; Li, ZJ; et al. Electrogenerated chemiluminescence biosensing for the detection of prostate PC-3 cancer cells incorporating antibody as capture probe and ruthenium complex-labelled wheat germ agglutinin as signal probe. ANALYTICA CHIMICA ACTA 863:1-8(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Is there a relationship between the structure and function of PC proteins? 10/06/2023

The structure of the PC protein determines its ability and stability to bind to DNA. The study of its structure can help us understand its function and mechanism of action.

What are the therapeutic strategies for PC protein? 02/03/2023

Therapeutic strategies for PC protein may include inhibiting its expression, blocking its binding to DNA, or regulating its associated signal transduction pathways. These methods may have potential applications in cancer treatment.

What is the specific role of PC protein in cancer? 11/13/2022

In cancer, PC proteins may play a role by promoting processes such as DNA replication, repair, and regulation of the cell cycle, thus promoting tumor growth and spread. It could be a potential target for cancer treatment.

What factors should be considered for drug development targeting PC proteins? 08/13/2022

Drug development targeting PC proteins needs to consider their specificity, safety, pharmacokinetic properties, and potential side effects. In addition, issues such as the dosage form, route of administration and design of clinical trials need to be considered.

How do PC proteins interact with other proteins? 12/17/2020

The proteins can interact with a variety of other proteins, including DNA repair enzymes, cell cycle regulators, and more. These interactions allow it to regulate the regulatory processes of DNA replication, repair and the cell cycle.

Is there a correlation between PC protein expression and disease? 02/03/2020

Recently published articles indicate that the expression level of PC protein is related to the occurrence and development of certain cancers. The highly expressed PC protein may promote tumor growth and spread and thus may be a potential therapeutic target.

Customer Reviews (3)

Write a review
Reviews
06/19/2023

    With the use of PC, the experiment is highly reproducible and convenient for data analysis.

    01/11/2022

      It is analyzed by X-ray crystallography or other crystallization techniques, and has good crystallization properties.

      08/05/2021

        It has a short half-life and high clearance.

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