PCSK2

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PCSK2

Official Full Name proprotein convertase subtilisin/kexin type 2
Background This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The protein undergoes an initial autocatalytic processing event and interacts with a neuroendocrine secretory protein in the ER, exits the ER and sorts to secretory granules, where it is cleaved and catalytically activated during intracellular transport. The encoded protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2014]
Synonyms PCSK2; proprotein convertase subtilisin/kexin type 2; PC2; NEC2; SPC2; NEC 2; NEC-2; neuroendocrine convertase 2; prohormone convertase 2; KEX2-like endoprotease 2;
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Rat PCSK2-2083R Recombinant Rat PCSK2 Protein (109-637 aa), His-tagged E.coli His
    Human PCSK2-2293H Recombinant Human PCSK2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Pcsk2-4721M Recombinant Mouse Pcsk2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human PCSK2-3371HCL Recombinant Human PCSK2 293 Cell Lysate HEK293 N/A
    Human PCSK2-523H Recombinant Human PCSK2 Protein, His-tagged E.coli His
    Human PCSK2-88H Recombinant Human PCSK2, His-tagged CHO His
    Mouse PCSK2-12515M Recombinant Mouse PCSK2 Protein Mammalian Cell His
    Rat PCSK2-4307R Recombinant Rat Pcsk2 protein, His-tagged HEK293 His
    Rhesus Macaque PCSK2-3333R Recombinant Rhesus monkey PCSK2 Protein, His-tagged Mammalian Cell His
    Zebrafish PCSK2-7236Z Recombinant Zebrafish PCSK2 Mammalian Cell His

    PCSK2 involved in several pathways and played different roles in them. We selected most pathways PCSK2 participated on our site, such as Insulin processing, Metabolism of proteins, Peptide hormone metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCSK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Insulin processing SLC30A8; SLC30A6; EXOC3; KIF5A; RAB27A; KIF5B; EXOC6; PCSK2; EXOC1; SLC30A5
    Metabolism of proteins TOMM6; EIF4H; SLC30A5; PFDN2; TBCD; PROZ; GRPEL2; O3far1; GPR120; DAD1
    Peptide hormone metabolism EXOC8; GPR119; SPCS3; CPA3; PCSK2; CPN1; GRP; CPE; O3far1; SLC30A6

    PCSK2 has several biochemical functions, for example, protein binding, protein complex binding, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PCSK2 itself. We selected most functions PCSK2 had, and list some proteins which have the same functions with PCSK2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding PCBP2; C4orf26; Fgf15; NKD2; MINOS1; SEPT1; ZCCHC8; CETN1; MTAP1B; KRTAP5-6
    protein complex binding CCND1; LCK; UGT1A6A; GNB1; MYC; HADHA; TULP3; ITPR1; COG2; SHANK1
    serine-type endopeptidase activity MCPT1; HGFA; CTRB1; ST14; PRSS39; PRSS1; PIK3IP1; KLK13; F9B; KLK1B4

    PCSK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCSK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCSK2.

    Berger, JM; Vaillant, N; et al. PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension. ATHEROSCLEROSIS 239:252-259(2015).
    de Keyser, CE; Becker, ML; et al. The rs13064411 polymorphism in the WDR52 gene, associated with PCSK9 levels, modifies statin-induced changes in serum total and LDL cholesterol levels. PHARMACOGENETICS AND GENOMICS 25:134-142(2015).

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