pde3a
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  • Official Full Name
  • PDE3A phosphodiesterase 3A, cGMP-inhibited
  • Background
  • Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3, 5monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling. The PDE3 enzyme belongs to a family of PDEs known as cGMPinhibited PDEs. The enzymes bind both cGMP and cAMP with different affinities. The PDE3 family is comprised of two genes, PDE3A and PDE3B
  • Synonyms
  • PDE3A; phosphodiesterase 3A, cGMP-inhibited; cGMP-inhibited 3,5-cyclic phosphodiesterase A; CGI PDE; cyclic GMP-inhibited phosphodiesterase A; cAMP phosphodiesterase, myocardial cGMP-inhibited; CGI-PDE; CGI-PDE A; CGI-PDE-A; FLJ37884
Cat.#:Pde3a-301RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pde3a Protein, His/GST-tagged
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Cat.#:PDE3A-29931THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PDE3A
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Cat.#:PDE3A-473HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PDE3A, GST-tagged, Active
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Cat.#:PDE3A-7332HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PDE3A, His & GST tagged
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Cat.#:PDE3A-4328RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PDE3A Protein
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Cat.#:PDE3A-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PDE3A cell lysate
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Cat.#:Kit-1834Tag:
Source (Host):Species:
Product namePDE3A Assay Kit
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Cat.#:Kit-1835Tag:
Source (Host):Species:
Product namePDE3A TR-FRET Assay Kit
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Involved Pathway

PDE3A involved in several pathways and played different roles in them. We selected most pathways PDE3A participated on our site, such as Purine metabolism, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
PDE6A; PFAS; AK1; NT5C3B; POLR2K; ADKB; POLR3E; POLR3A; GUK1; POLR2EB
cGMP-PKG signaling pathway
SLC8A1; IRS1; GTF2I; ATP1B3; ATP2A1; VASP; VDAC2; GNAI2; PPP1CC; Adcy4
cAMP signaling pathway
PRKACA; FOS; PPARA; MAPK1; ROCK2; CALM1; PDE3A; LIPE; AKT1; CNGA2
Renin secretion
CLCA2; Ren1; CALM4; AGTR1B; GNAS; CALM2; CALM3; CLCA5; PTGER4; GNAQ
Morphine addiction
OPRM1; GNAO1; GNB2; GNG10; PRKCG; GABRR1; PRKACA; GABRA6; PDE10A; GABRB2

Protein Function

PDE3A has several biochemical functions, for example, 3,5-cyclic-AMP phosphodiesterase activity, cAMP binding, cGMP-inhibited cyclic-nucleotide phosphodiesterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE3A itself. We selected most functions PDE3A had, and list some proteins which have the same functions with PDE3A. You can find most of the proteins on our site.
Function
Related Protein
Function 3,5-cyclic-AMP phosphodiesterase activity
Related Protein PDE4C; PDE4D; PDE4B; PDE8B; PDE1B; PDE4A; PDE7A; TDP2B; PDE8A; PDE7B
Function cAMP binding
Related Protein PRKAR1B; POPDC2; CNGA4; PRKAR1A; PRKAR2A; HCN2; CNMPD1; CNGA2; PDE3A; PDE2A
Function cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
Related Protein TDP2B; PDE3B; USB1; PDE3A
Function metal ion binding
Related Protein CISD1; HECTD1; KDM7AB; SUV39H1A; ZFP143; FKBP8; TRIM109; PPM1G; CNBPA; A3GALT2

Interacting Protein

PDE3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE3A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE3A.
YWHAZ; Pcdh1; Cenpe; WDR62; HSPA5; BMH1; KIF11; Ccser2; CCDC88A; Cep44; Kctd5; Spred2; TUBA1C; Cenph; FBXO7

PDE3A Related Articles

Uckert, S; Waldkirch, ES; et al. Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Seminal Vesicles. JOURNAL OF SEXUAL MEDICINE 8:3058-3065(2011).
Proenca-Ferreira, R; Franco-Penteado, CF; et al. Increased adhesive properties of platelets in sickle cell disease: roles for alpha(IIb)beta(3)-mediated ligand binding, diminished cAMP signalling and increased phosphodiesterase 3A activity. BRITISH JOURNAL OF HAEMATOLOGY 149:280-288(2010).