Recombinant Human PDE3A
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Cat.No. : | PDE3A-29931TH Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant fragment of Human PDE3A with N-terminal proprietary tag.Mol Wt 37.51 kDa inclusive of tag. |
Description : | This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. |
Protein length : | 108 amino acids |
Molecular Weight : | 37.510kDa inclusive of tags |
Source : | Wheat germ |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris buffered saline |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | TPASSLVSKI SAVQFPESAD TTAKQSLGSH RALTYTQSAP DLSPQILTPP VICSSCGRPY SQGNPADEPL ERSGVATRTP SRTDDTAQVT SDYETNNNSD SSDIVQNE |
Sequence Similarities : | Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily. |
Gene Name : | PDE3A phosphodiesterase 3A, cGMP-inhibited [ Homo sapiens ] |
Official Symbol : | PDE3A |
Synonyms : | PDE3A; phosphodiesterase 3A, cGMP-inhibited; cGMP-inhibited 3,5-cyclic phosphodiesterase A; CGI PDE; |
Gene ID : | 5139 |
mRNA Refseq : | NM_000921 |
Protein Refseq : | NP_000912 |
MIM : | 123805 |
Uniprot ID : | Q14432 |
Chromosome Location : | 12p12.2 |
Pathway : | G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Hemostasis, organism-specific biosystem; Insulin signaling pathway, organism-specific biosystem; Insulin signaling pathway, conserved biosystem; |
Function : | 3,5-cyclic-AMP phosphodiesterase activity; cAMP binding; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; hydrolase activity; metal ion binding; |
◆ Recombinant Protein
PDE3A-01H | Recombinant Human PDE3A Protein, His/GST-tagged | +Inquiry |
Pde3a-301R | Recombinant Rat Pde3a Protein, His/GST-tagged | +Inquiry |
PDE3A-018H | Recombinant Human PDE3A Protein, His/GST-tagged | +Inquiry |
PDE3A-7332H | Recombinant Human PDE3A, His & GST tagged | +Inquiry |
PDE3A-4328R | Recombinant Rat PDE3A Protein | +Inquiry |
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◆ Lysates
PDE3A-001HCL | Recombinant Human PDE3A cell lysate | +Inquiry |
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◆ Assay kits
Kit-1835 | PDE3A TR-FRET Assay Kit | +Inquiry |
Kit-1834 | PDE3A Assay Kit | +Inquiry |
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Pde10aPDE11APDE1APDE1BPde1cPDE2APDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE6BPDE6CPDE6DPDE7APDE7BPDE8APDE9APDE4DIPPDE12PDE6APDE8BPDE6GPDE6H
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