PDE3B

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PDE3B

Official Full Name PDE3B phosphodiesterase 3B, cGMP-inhibited
Background Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3, 5monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling. The PDE3 enzyme belongs to a family of PDEs known as cGMPinhibited PDEs. The enzymes bind both cGMP and cAMP with different affinities. The PDE3 family is comprised of two genes, PDE3A and PDE3B
Synonyms PDE3B; phosphodiesterase 3B, cGMP-inhibited; cGMP-inhibited 3,5-cyclic phosphodiesterase B; HcGIP1; CGIP1; CGI-PDE B; cyclic nucleotide phosphodiesterase; cyclic GMP-inhibited phosphodiesterase B; cGIPDE1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Pde3b-4744M Recombinant Mouse Pde3b Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human PDE3B-6370H Recombinant Human PDE3B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human PDE3B-1526H Recombinant Human PDE3B (Active), GST-tagged Sf9 Insect Cell GST
    Human PDE3B-29932TH Recombinant Human PDE3B N/A
    Human PDE3B-474H Recombinant Human PDE3B, GST-tagged, Active Sf9 Insect Cell GST
    Human PDE3B-742H Recombinant Human PDE3B Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Rat PDE3B-4329R Recombinant Rat PDE3B Protein Mammalian Cell His
    Chicken PDE3B-2849C Recombinant Chicken PDE3B Mammalian Cell His
    Kit-1836 PDE3B Assay Kit I N/A
    Kit-1837 PDE3B Assay Kit II N/A

    PDE3B involved in several pathways and played different roles in them. We selected most pathways PDE3B participated on our site, such as Purine metabolism, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolism ENTPD6; IMPDH1; PAICS; ENTPD2; GC3; AK3; GC2; POLR2J; ADPRM; CANT1A
    cGMP-PKG signaling pathway ROCK2; CALM4; PPP3CB; GUCY1B3; PIK3R3; GUCY1A3; INS; GNAI3; AGTR1B; ATP1A3
    cAMP signaling pathway NFKB1; PPP1CA; PPARA; TSHR; RAF1; CAMK2B; HTR6; VAV2; PDE3A; GRIA1
    Insulin signaling pathway G6PC; PIK3R2; EIF4E1C; SHC3; SOCS1; MAP2K2B; TSC1; SOCS3; PPP1R3CA; PPARGC1A
    Progesterone-mediated oocyte maturation CPEB1; PLK1; CDC16; HSP90AA1; RAF1A; MAPK3; MAPK8B; PRKACAB; MAPK12B; KRAS
    Glucagon signaling pathway PLCB1; CREB3L2; EP300; PRKAG2; ITPR1; CAMK2B; PPP3CB; ATF4; G6PC3; CPT1C
    Regulation of lipolysis in adipocytes NPY1R; PRKACB; GNAI1; GNAI3; INS1; PRKG2; AKT1; PDE3B; PIK3R2; Adcy4
    Renin secretion PLCB1; ITPR1; CALM2; GNAI2; PPP3CB; PTGER2; CLCA1; CALML3; CLCA5; ORAI1
    Morphine addiction GNG8; GNAS; GNG11; GNG12; GNB3; OPRM1; PDE1B; GABRB2; ADORA1; GABRA6

    PDE3B has several biochemical functions, for example, 3,5-cyclic-nucleotide phosphodiesterase activity, cGMP-inhibited cyclic-nucleotide phosphodiesterase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE3B itself. We selected most functions PDE3B had, and list some proteins which have the same functions with PDE3B. You can find most of the proteins on our site.

    Function Related Protein
    3,5-cyclic-nucleotide phosphodiesterase activity PDE5AB; PDE8A; PDE11A; PDE9A; PDE10A; PDE3B; PDE6D; PDE4D; PDE5A; PDE8B
    cGMP-inhibited cyclic-nucleotide phosphodiesterase activity PDE3B; USB1; TDP2B; PDE3A
    metal ion binding GDPD3; NT5C2A; ALPL; MPO; ZDHHC15A; CAR15; PRDM12B; METAP1D; GNAZ; ZFP143
    protein binding ESRP1; REEP1; OLFM4; CREBBP; PAGE2; SH2D4A; SNX8; GTF3C4; ATP1B2; AKAP13
    protein kinase B binding PINK1; TRAF6; CCDC88A; BCL10; PDE3B; RARA; BAD; APPL1; CDC37; ANKRD2

    PDE3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE3B here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE3B.

    RAPGEF3; PIK3R6; PIK3CG

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