pde3b
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  • Official Full Name
  • PDE3B phosphodiesterase 3B, cGMP-inhibited
  • Background
  • Cyclic nucleotide phosphodiesterases (PDEs) catalyse the hydrolytic inactivation of the common intracellular second messengers cyclic adenosine and guanosine 3, 5monophosphate (cAMP and cGMP). Thus, these enzymes play a critical role in the regulation of a wide range of physiological processes modulated by cyclic nucleotide signalling. The PDE3 enzyme belongs to a family of PDEs known as cGMPinhibited PDEs. The enzymes bind both cGMP and cAMP with different affinities. The PDE3 family is comprised of two genes, PDE3A and PDE3B
  • Synonyms
  • PDE3B; phosphodiesterase 3B, cGMP-inhibited; cGMP-inhibited 3,5-cyclic phosphodiesterase B; HcGIP1; CGIP1; CGI-PDE B; cyclic nucleotide phosphodiesterase; cyclic GMP-inhibited phosphodiesterase B; cGIPDE1
Cat.#:PDE3B-742HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PDE3B Protein, MYC/DDK-tagged
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Cat.#:PDE3B-29932THTag:
Source (Host):Species:Human
Product nameRecombinant Human PDE3B
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Cat.#:PDE3B-474HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PDE3B, GST-tagged, Active
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Cat.#:PDE3B-4329RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PDE3B Protein
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Cat.#:PDE3B-2849CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PDE3B
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Cat.#:PDE3B-1526HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PDE3B (Active), GST-tagged
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Cat.#:Kit-1836Tag:
Source (Host):Species:
Product namePDE3B Assay Kit I
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Cat.#:Kit-1837Tag:
Source (Host):Species:
Product namePDE3B Assay Kit II
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Involved Pathway

PDE3B involved in several pathways and played different roles in them. We selected most pathways PDE3B participated on our site, such as Purine metabolism, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
GUCY2C; PGM1; ENTPD6; ITPA; PDE6H; PDE4A; PKLR; ENPP3; GMPR; URAH
cGMP-PKG signaling pathway
MYH7; NPR2; PLN; GUCY1B3; PRKG2; ATP1B4; PPP3CA; RGS2; GNA12; SRF
cAMP signaling pathway
PPP1CB; HCAR2; GRIN2C; FSHR; HTR1E; PPP1CC; PDE4D; ATP1B1; PLD2; CAMK2G
Insulin signaling pathway
PPP1CAA; MAPK8B; RPS6; HRASA; PRKAR1B; MAPK8A; PPP1CC; PIK3CG; CALM3; CALM2
Progesterone-mediated oocyte maturation
CDC27; MAPK14A; MAPK12; IGF1RB; SPDYB; GNAI1; HSP90AA1.2; PDE3B; MAP2K1; RPS6KA3B
Glucagon signaling pathway
CREB3L1; PRMT1; PPP4C; PPARA; AKT1; PRKAA1; PLCB2; PFKFB1; CALM3; PDHA1
Regulation of lipolysis in adipocytes
PIK3CA; TSHB; NPY; INS; INS2; INS1; PLIN1; PIK3CD; PTGS2; IRS4
Renin secretion
PRKG2; GNAQ; CALML3; AQP1; PLCB1; CALM4; GUCY1B3; ORAI1; CLCA1; PRKACA
Morphine addiction
GNAI1; PDE1C; GABRA6; GNG2; GNG12; GNG10; GABRA3; PDE3A; GABRP; PDE3B

Protein Function

PDE3B has several biochemical functions, for example, 3,5-cyclic-nucleotide phosphodiesterase activity, cGMP-inhibited cyclic-nucleotide phosphodiesterase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE3B itself. We selected most functions PDE3B had, and list some proteins which have the same functions with PDE3B. You can find most of the proteins on our site.
Function
Related Protein
Function 3,5-cyclic-nucleotide phosphodiesterase activity
Related Protein PDE11A; PDE3B; PDE10A; PDE8A; PDE4D; PDE8B; PDE9A; PDE6D; PDE5A; PDE5AB
Function cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
Related Protein TDP2B; PDE3A; USB1; PDE3B
Function metal ion binding
Related Protein STK32C; TMPPE; HERC2; RNF148; HBAA1; ZC3HAV1; CISD1; DSG1C; SAP30; MTMR4
Function protein binding
Related Protein FAM107A; APBA2; C18orf1; C3orf62; LITAF; NOL12; HTT; PNPT1; SLC8A1; VPS52
Function protein kinase B binding
Related Protein ANKRD2; TRAF6; CCDC88A; BCL10; PDE3B; PINK1; APPL1; RARA; CDC37; BAD

Interacting Protein

PDE3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE3B here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE3B.
RAPGEF3; PIK3R6; PIK3CG