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PEX12

  • Official Full Name

    peroxisomal biogenesis factor 12

  • Overview

    This gene belongs to the peroxin-12 family. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS).
  • Synonyms

    PEX12; peroxisomal biogenesis factor 12; peroxisome assembly protein 12; CG3; PAF 3; Peroxin 12; Peroxin12; Peroxisome assembly factor 3; Peroxisome biogenesis disorder, complementation group 3, included; PEX 12; peroxin-12; OTTHUMP00000163882; PAF-3;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Arabidopsis thaliana (Mouse-ear cress)
  • Bos taurus (Bovine)
  • Cricetulus longicaudatus (Long-tailed dwarf hamster) (Chinese hamster)
  • Cynomolgus Monkey
  • Dictyostelium discoideum (Slime mold)
  • Drosophila melanogaster (Fruit fly)
  • Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
  • Homo sapiens (Human)
  • Human
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Zebrafish
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PEX12-3293HCL Recombinant Human PEX12 293 Cell Lysate HEK293 N/A
Rat PEX12-4381R Recombinant Rat PEX12 Protein Mammalian Cell His
Rat PEX12-4041R Recombinant Rat PEX12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PEX12-4041R-B Recombinant Rat PEX12 Protein Pre-coupled Magnetic Beads HEK293
Arabidopsis thaliana (Mouse-ear cress) RFL33997AF Recombinant Full Length Arabidopsis Thaliana Peroxisome Biogenesis Protein 12(Pex12) Protein, His-Tagged E.coli expression system His Full Length (1-393)
Bos taurus (Bovine) RFL10845BF Recombinant Full Length Bovine Peroxisome Assembly Protein 12(Pex12) Protein, His-Tagged E.coli expression system His Full Length (1-359)
Cricetulus longicaudatus (Long-tailed dwarf hamster) (Chinese hamster) RFL4060CF Recombinant Full Length Cricetulus Longicaudatus Peroxisome Assembly Protein 12(Pex12) Protein, His-Tagged E.coli expression system His Full Length (1-359)
Cynomolgus Monkey PEX12-780C Recombinant Cynomolgus PEX12 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey PEX12-524C Recombinant Cynomolgus Monkey PEX12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey PEX12-524C-B Recombinant Cynomolgus Monkey PEX12 Protein Pre-coupled Magnetic Beads HEK293
Dictyostelium discoideum (Slime mold) RFL16763DF Recombinant Full Length Dictyostelium Discoideum Putative Peroxisome Assembly Protein 12(Pex12) Protein, His-Tagged E.coli expression system His Full Length (1-459)
Drosophila melanogaster (Fruit fly) RFL15562DF Recombinant Full Length Drosophila Melanogaster Putative Peroxisome Assembly Protein 12(Pex12) Protein, His-Tagged E.coli expression system His Full Length (1-297)
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) RFL21124EF Recombinant Full Length Emericella Nidulans Peroxisome Assembly Protein 12(Pex12) Protein, His-Tagged E.coli expression system His Full Length (1-489)
Homo sapiens (Human) RFL20537HF Recombinant Full Length Human Peroxisome Assembly Protein 12(Pex12) Protein, His-Tagged E.coli expression system His Full Length (1-359)
Mus musculus (Mouse) RFL3803MF Recombinant Full Length Mouse Peroxisome Assembly Protein 12(Pex12) Protein, His-Tagged E.coli expression system His Full Length (1-359)
Rattus norvegicus (Rat) RFL22141RF Recombinant Full Length Rat Peroxisome Assembly Protein 12(Pex12) Protein, His-Tagged E.coli expression system His Full Length (1-359)
Zebrafish PEX12-10549Z Recombinant Zebrafish PEX12 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PEX12 involved in several pathways and played different roles in them. We selected most pathways PEX12 participated on our site, such as Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PEX12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PeroxisomePEX11G;CRATB;HAO2;ACAA1A;ACSL1B;BAAT;PEX26;CAT;FAR2

PEX12 has several biochemical functions, for example, protein C-terminus binding, protein binding, ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PEX12 itself. We selected most functions PEX12 had, and list some proteins which have the same functions with PEX12. You can find most of the proteins on our site.

Function Related Protein
protein C-terminus bindingTBL1X;XRCC4;PABPC1;PEX12;ID1;TAX1BP3;PRDX3;PIAS3;VPS4A
protein bindingLIN37;CCNE1;APPL1;FTL;HOXB7;PDE6D;FGFR3;HEMGN;TNFAIP3
ubiquitin-protein transferase activityTRAF3;UBE2O;UBE2L3;UBE2Q2;RNF168;ARIH2;G2E3;RNF181;RNF144AA
zinc ion bindingZDHHC5;LMO1;DPF2L;TRAF4B;RNF180;TRIM35-24;ADAMTS18;KDM4B;SETDB1B

PEX12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PEX12 here. Most of them are supplied by our site. Hope this information will be useful for your research of PEX12.

PEX5; PEX19; PEX5

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