pex12
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  • Official Full Name
  • peroxisomal biogenesis factor 12
  • Background
  • This gene belongs to the peroxin-12 family. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS).
  • Synonyms
  • PEX12; peroxisomal biogenesis factor 12; peroxisome assembly protein 12; CG3; PAF 3; Peroxin 12; Peroxin12; Peroxisome assembly factor 3; Peroxisome biogenesis disorder, complementation group 3, included; PEX 12; peroxin-12; OTTHUMP00000163882; PAF-3
Cat.#:PEX12-4381RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PEX12 Protein
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Cat.#:PEX12-780CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus PEX12 Protein, His-tagged
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Cat.#:PEX12-10549ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PEX12
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Cat.#:PEX12-3293HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PEX12 293 Cell Lysate
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Involved Pathway

PEX12 involved in several pathways and played different roles in them. We selected most pathways PEX12 participated on our site, such as Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PEX12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Peroxisome
PEX6; CRATB; CRATA; NOS2B; PMVK; XDH; BAAT; HMGCL; ACSL3; AGXTB

Protein Function

PEX12 has several biochemical functions, for example, protein C-terminus binding, protein binding, ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PEX12 itself. We selected most functions PEX12 had, and list some proteins which have the same functions with PEX12. You can find most of the proteins on our site.
Function
Related Protein
Function protein C-terminus binding
Related Protein BCL10; NPAT; VGLL3; OPRL1; IFT52; SIRT1; TCF4; SIAH1A; PROP1; XRCC6
Function protein binding
Related Protein ATG7; SLC7A11; CLEC4G; IK; RPL39L; AIPL1; EME1; VIP; FRK; ACYP2
Function ubiquitin-protein transferase activity
Related Protein PRP19; SMURF1; FLJ11011L; ARIH1L; UBE2G2; TRIM27; RNF217; IRAK1; RNF43; MARCH4
Function zinc ion binding
Related Protein RAI1; ZPR1; FBXL19; GTF2H2; ISL2; AMFR; ATXN7L3; TRIM67; BRPF1; GM757

Interacting Protein

PEX12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PEX12 here. Most of them are supplied by our site. Hope this information will be useful for your research of PEX12.
PEX5; PEX19; PEX5