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PFKP

  • Official Full Name

    phosphofructokinase, platelet

  • Overview

    The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK);(ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of;fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which;maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM;171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) (PubMed;6451249) determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits;P4, P3L, and P2L2.
  • Synonyms

    PFKP; phosphofructokinase, platelet; 6-phosphofructokinase type C; PFK C; PFKF; Phosphofructokinase; platelet type; phosphohexokinase; phosphofructokinase 1; phosphofructo-1-kinase isozyme C; Phosphofructokinase, platelet type; 6-phosphofructokinase, plat;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • GST
  • His|T7
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PFKP-30890TH Recombinant Human PFKP, His-tagged E.coli His
Human PFKP-3270HCL Recombinant Human PFKP 293 Cell Lysate HEK293 N/A
Human PFKP-284HFL Active Recombinant Full Length Human PFKP Protein, C-Flag-tagged Mammalian cells Flag
Human PFKP-01H Active Recombinant Human PFKP Protein, MYC/DDK-tagged HEK293T Myc/DDK
Human PFKP-1654H-B Recombinant Human PFKP Protein Pre-coupled Magnetic Beads HEK293
Human PFKP-607H Recombinant Human PFKP Protein (Met1-Val784), His-GST-tagged Insect Cells His/GST Met1-Val784
Human PFKP-1654H Recombinant Human PFKP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PFKP-4872H Recombinant Human PFKP Protein (Asp553-Lys753), N-His tagged E.coli N-His Asp553-Lys753
Mouse PFKP-12666M Recombinant Mouse Pfkp Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Pfkp-1737M Recombinant Mouse Pfkp protein, His & T7-tagged E.coli His/T7 Trp247~Gly473 (Accession # Q9WUA3)
Mouse Pfkp-4811M Recombinant Mouse Pfkp Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Pfkp-1738R Recombinant Rat Pfkp protein, His & T7-tagged E.coli His/T7 Arg354~Ala570 (Accession # P47860)
Chicken PFKP-3156C Recombinant Chicken PFKP Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PFKP involved in several pathways and played different roles in them. We selected most pathways PFKP participated on our site, such as Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Fructose and mannose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PFKP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycolysis / GluconeogenesisAKR1A1A;DLDH;ADH2-2;ENO1B;ACSS1;G6PCA.2;TPI1A;PDHA1A;FBP1B
Pentose phosphate pathwayALDOC;ALDOAA;RPE;TKTL1;ALDOCB;PGD;FBP2;PRPS1L1;PRPS1B
Fructose and mannose metabolismPFKP;PFKFB3;DHRS13L1;ENOSF1;Akr1b3;ALDOB;ALDOA;FBP1;ALDOCB
Galactose metabolismSI;G6PC3;LALBA;B4GALT1;aLA;AKR1B10;PGM1;GLA;GANC
Metabolic pathwaysPOLR2A;POLG;GRHPR;DCT;GCDHA;AGPAT4;B4GALT6;TK2;CEPT1B
Carbon metabolismPC;MUT;ECHS1;ME2;ACAT2;ANI_1_2390104;GLDC;ACADM;PHGDH
Biosynthesis of amino acidsALDOB;GLULA;PGK2;PRPS2;CBSA;ACO1;ARG2;ASL;PCXB
RNA degradationPFKMB;DCP1A;LSM2;ZCCHC7;EXOSC2;PAN2;PNPT1;TOB1A;TOB1B
AMPK signaling pathwayFOXO1;STRADB;STRADA;RAB11B;EIF4EBP1;PCK1;PIK3R2;PIK3R3;TSC2
Thyroid hormone signaling pathwayRXRB;NRAS;ATP1A2;CCND1;KAT2B;PIK3R3;EP300;SIN3A;ATP2A2
Central carbon metabolism in cancerPDGFRA;SLC1A5;HK3;PIK3R3;PKM;PGAM2;PFKP;PDGFRB;FLT3

PFKP has several biochemical functions, for example, 6-phosphofructokinase activity, ATP binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PFKP itself. We selected most functions PFKP had, and list some proteins which have the same functions with PFKP. You can find most of the proteins on our site.

Function Related Protein
6-phosphofructokinase activityPFKLB;PFKL;PFKM;PFKMA;PFKP;PFKMB
ATP bindingUBE2J2;ACTA2;ABCA3;ACTR2;EPHA7;ATP1A3;RPS6KA3A;MAGI3;CDK11B
metal ion bindingPGGT1B;BMPR1B;LNX2A;HPX;RNF26;ADAP1;ITGAM;TRIM35-23;ZNHIT6
protein complex bindingEPHB1;MLC1;RNF40;STRN;FADD;VPS28;LRP2;RPAIN;KAT6B

PFKP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PFKP here. Most of them are supplied by our site. Hope this information will be useful for your research of PFKP.

GBAS; BCAR3; TNFRSF1B; MCC; HLA-B; GABARAPL2; MAX; ARF6; YWHAZ; DMWD; GSTK1; PRKAB1; TRAF6; WIPI2; TERF1; ACD; TINF2; WNK1

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