pfkp
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  • Official Full Name
  • phosphofructokinase, platelet
  • Background
  • The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK);(ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of;fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which;maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM;171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) (PubMed;6451249) determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits;P4, P3L, and P2L2.
  • Synonyms
  • PFKP; phosphofructokinase, platelet; 6-phosphofructokinase type C; PFK C; PFKF; Phosphofructokinase; platelet type; phosphohexokinase; phosphofructokinase 1; phosphofructo-1-kinase isozyme C; Phosphofructokinase, platelet type; 6-phosphofructokinase, plat
Cat.#:PFKP-607HTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PFKP Protein (Met1-Val784), His-GST-tagged
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Cat.#:PFKP-30890THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PFKP, His-tagged
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Cat.#:PFKP-12666MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PFKP Protein
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Cat.#:Pfkp-1737MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pfkp protein, His & T7-tagged
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Cat.#:Pfkp-1738RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pfkp protein, His & T7-tagged
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Cat.#:PFKP-3156CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PFKP
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Cat.#:PFKP-3270HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PFKP 293 Cell Lysate
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Involved Pathway

PFKP involved in several pathways and played different roles in them. We selected most pathways PFKP participated on our site, such as Glycolysis / Gluconeogenesis, Pentose phosphate pathway, Fructose and mannose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PFKP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycolysis / Gluconeogenesis
PGK1; PKMB; FBP1; PGAM2; PGK2; ADH1C; ADH7; LDHB; GAPDHS; ALDOAA
Pentose phosphate pathway
ALDOA; ALDOCA; ALDOAB; PRPS2; PRPS1L1; FBP1A; GPI; PGM1; RGN; PRPS1A
Fructose and mannose metabolism
PFKFB1; TIGARA; GMPPA; ALDOCB; HK3; FBP1A; ENOSF1; TIGARB; GMDS; GMPPB
Galactose metabolism
GLB1; HK1; HK3; AKR1B10; PFKM; PGM1; HKDC1; LALBA; G6PC3; HK2
Metabolic pathways
ST3GAL5; IDO2; XYLT1; GALNT18A; PTGIS; Amy1; COQ7; ALDH5A1; NDUFA9; PDHA1B
Carbon metabolism
GM5506; HK3; PSAT1; PC; SDHA; ENO1B; MCEE; GPT2L; PGLS; IDH3G
Biosynthesis of amino acids
ASL2; GPT2L; CBSB; PYCR1B; GOT1; PFKL; PGAM1; MAT2B; ENO3; PGAM2
RNA degradation
DCP1B; DIS3L; C1D; ENO1; TTC37; PABPC5; PABPC3; LSM4; TOB1; SKIV2L
AMPK signaling pathway
ADIPOR2; PIK3R5; CPT1B; PRKAA2; STK11; PFKL; MTOR; G6PC; GYS1; IRS1
Thyroid hormone signaling pathway
RXRB; HDAC1; ATP1A3; STAT1; MED4; RHEB; NRAS; MAP2K1; BMP4; KAT2B
Central carbon metabolism in cancer
HKDC1; MAP2K2; PFKL; FGFR1; FGFR3; SLC1A5; MTOR; AKT1; IDH1; HK1

Protein Function

PFKP has several biochemical functions, for example, 6-phosphofructokinase activity, ATP binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PFKP itself. We selected most functions PFKP had, and list some proteins which have the same functions with PFKP. You can find most of the proteins on our site.
Function
Related Protein
Function 6-phosphofructokinase activity
Related Protein PFKM; PFKMA; PFKL; PFKMB; PFKLB; PFKP
Function ATP binding
Related Protein GATB; ACSS3; DHX32; CAMK2B1; ITGB1BP3; NMNAT2; MAP3K3; PHKG1A; FASTK; RFC2
Function metal ion binding
Related Protein TESK2; RBAK; ZNF773; DMRTA1; CYP51; MAT1A; GLI2B; ZNF557; U2AF1L4; MICALL2
Function protein complex binding
Related Protein LZTFL1; PPP2R2A; CASP8; PEX26; ABI1; NFKBIA; GRIN2A; C8B; TAB1; TRADD

Interacting Protein

PFKP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PFKP here. Most of them are supplied by our site. Hope this information will be useful for your research of PFKP.
GBAS; BCAR3; TNFRSF1B; MCC; HLA-B; GABARAPL2; MAX; ARF6; YWHAZ; DMWD; GSTK1; PRKAB1; TRAF6; WIPI2; TERF1; ACD; TINF2; WNK1