pgr
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  • Official Full Name
  • progesterone receptor
  • Background
  • This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Jan 2011]
  • Synonyms
  • PGR; progesterone receptor; PR; NR3C3; nuclear receptor subfamily 3 group C member 3;
Cat.#:PGR-106HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Progesterone receptor LBD/Hsp90 complex, GST-tagged
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Cat.#:PGR-182HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Progesterone Receptor
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Cat.#:PGR-183HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PGR protein, MYC/DDK-tagged
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Cat.#:PGR-20HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PGR protein, GST-tagged
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Cat.#:PGR-228HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human PGR, StrepII-tagged
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Cat.#:PGR-29707THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PGR
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Cat.#:PGR-6753HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PGR protein, His & T7-tagged
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Cat.#:PGR-4410RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PGR Protein
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Cat.#:Pgr-6754RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pgr protein, His & T7-tagged
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Cat.#:PGR-3395RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PGR Protein, His-tagged
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Cat.#:PGR-6814CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PGR
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Cat.#:PGR-7617ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PGR
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Cat.#:Kit-1995Tag:N/A
Source (Host):Species:
Product namePGR (human) Reporter Assay Kit
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Involved Pathway

PGR involved in several pathways and played different roles in them. We selected most pathways PGR participated on our site, such as Oocyte meiosis, Progesterone-mediated oocyte maturation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PGR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Oocyte meiosis
CAMK2B1; RBX1; CALM1B; INS2; SKP1; CALML3; MAPK1; MAPK12B; REC8B; PPP2R1B
Progesterone-mediated oocyte maturation
PRKACBB; PRKACA; CPEB2; CDC25B; MAPK12A; PLK1; ANAPC2; ANAPC4; MAD1L1; PRKACBA

Protein Function

PGR has several biochemical functions, for example, ATPase binding, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PGR itself. We selected most functions PGR had, and list some proteins which have the same functions with PGR. You can find most of the proteins on our site.
Function
Related Protein
Function ATPase binding
Related Protein NSFL1C; ATP6V1E1; ATP6V0A1; ALDOB; SYVN1; ATP6V1G3; ATP1B3; FXYD1; ATP6V1G1; SLN
Function DNA binding
Related Protein ZFP110; ZNF189; TSG101; GM239; ZNF703; YBX2; HOXC11A; FUS; ZFP473; UBN2A
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein SRF; NPAS4; MESP1; HIST2H3A; OTX1; CEBPZ; NFIA; NFATC2; MZF1; ZNF331
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein PPARAA; NR2F6B; NR2E3; PPARAB; NR2F5; NR2F6A; RORCA; RXRA; AHR2; RORAA
Function enzyme binding
Related Protein HSPA1B; NPM2; KMT2E; TARBP2; HIST1H2AE; BCL10; SCARB2; HYAL2; DHCR24; CD40
Function protein binding
Related Protein C10orf119; IL1R2; IGFL1; APOH; P2RY6; KCTD13; DLC1; AATF; KCNG4; FAM13C
Function receptor binding
Related Protein Itga10&Itgb1; ANG; SLC39A1; FZD8; MLN; DVL3; FGF13B; FASLG; IAPP; CD70
Function steroid binding
Related Protein HSD17B10; ESR2B; PGRMC2; ESR1; ESRRA; ESRRB; Ar; PAQR5A; CYP21A2; HSD11B2
Function steroid hormone receptor activity
Related Protein NR1H5; NR1H3; NR2F6B; NR5A1A; NR2F6; NR5A2; PPARG; OLFR78; RARAA; RORB
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein SOX12; NR4A1; ISL1; DBP; HLTF; ZFP639; NRF1; MYBL2; CAMTA1; TXK
Function zinc ion binding
Related Protein MORC3A; S100A12; NR6A1A; GATAD2B; NEURL1AA; AICDA; LIMA1; ABLIM1B; ZNF385B; GM757

Interacting Protein

PGR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PGR here. Most of them are supplied by our site. Hope this information will be useful for your research of PGR.
CUEDC2; STAT3; SP1; r_5020_promegestone; PRMT2; JDP2; SMARCD1

PGR Related Articles

Tosovic, A; Bondeson, AG; et al. T3 levels in relation to prognostic factors in breast cancer: a population-based prospective cohort study. BMC CANCER 14:-(2014).
Yardley, DA; Tripathy, D; et al. Long-term survivor characteristics in HER2-positive metastatic breast cancer from registHER. BRITISH JOURNAL OF CANCER 110:2756-2764(2014).