phkg2
Share
  • Official Full Name
  • phosphorylase kinase, gamma 2 (testis)
  • Background
  • Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9C, also known as autosomal liver glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
  • Synonyms
  • PHKG2; phosphorylase kinase, gamma 2 (testis); phosphorylase b kinase gamma catalytic chain, testis/liver isoform; PSK-C3; PHK-gamma-T; phosphorylase kinase subunit gamma-2; serine/threonine-protein kinase PHKG2; Phosphorylase kinase, gamma 2 (testis/live
Cat.#:PHKG2-1893HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Phosphorylase Kinase, Gamma 2 (testis), GST-tagged
+Inquiry
Cat.#:PHKG2-1686HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PHKG2, His-tagged
+Inquiry
Cat.#:PHKG2-30330THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PHKG2
+Inquiry
Cat.#:PHKG2-388HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PHKG2, GST-tagged, Active
+Inquiry
Cat.#:PHKG2-12741MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PHKG2 Protein
+Inquiry
Cat.#:PHKG2-4427RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PHKG2 Protein
+Inquiry
Cat.#:PHKG2-11197ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PHKG2
+Inquiry
Cat.#:PHKG2-3222HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PHKG2 293 Cell Lysate
+Inquiry

Involved Pathway

PHKG2 involved in several pathways and played different roles in them. We selected most pathways PHKG2 participated on our site, such as Calcium signaling pathway, Insulin signaling pathway, Glucagon signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PHKG2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcium signaling pathway
ATP2B1A; PTK2BB; PLCD3A; GRM5; EDNRB2; OXTR; CACNA1BA; PRKACBB; BDKRB1; PHKG1A
Insulin signaling pathway
CALM2B; FBP1; INSRB; MAP2K2; ACACA; INPPL1; CALM3A; SOCS9; PHKG2; TSC1A
Glucagon signaling pathway
CALM2; CALM1; G6PC2; CALML5; ITPR1; PDE3B; GNAS; PDHA2; PRKAA2; PFKL

Protein Function

PHKG2 has several biochemical functions, for example, ATP binding, calmodulin binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PHKG2 itself. We selected most functions PHKG2 had, and list some proteins which have the same functions with PHKG2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PRKAA2; STK24A; RPS6KA3A; UBE2J2; ABCF1; RUVBL1; GUCY2F; LYN; ACTR3; PIKFYVE
Function calmodulin binding
Related Protein CNN1A; PLCB3; TRPV1; MYO6; CAMK1GA; PLCB1; ADCY1; ADD2; MARCKS; MYLK
Function enzyme binding
Related Protein CLSTN2; EGFR; PLCB1; TAF10; MST1R; Slc4a2; NOTCH3; CNTNAP2; NKX2-1; STC2
Function phosphorylase kinase activity
Related Protein PHKA2; PHKG1; PHKG1B; PHKG2; PHKG1A; PHKB
Function protein serine/threonine kinase activity
Related Protein SQSTM1; SRPK1; RAF1A; SRPK1B; KSR2; PASK; FAM20C; STK35L; CDC42BPA; CDK11A
Function tau-protein kinase activity
Related Protein CSNK1D; MARK4; GSK3A; MARK2; CDK5; GSK3B; PHKG1; PRKAA1; PHKG2; MARK1

Interacting Protein

PHKG2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PHKG2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PHKG2.
PHKA2; disA; linkable sunitinib analogue; purvalanol b; PEX10; NDUFA4; GAK; SCO2; LAMC1; VDAC2; PHKA1; PHKA1; FASN; NPEPPS; HIST1H3D; PRKDC; ACACA; ATAD3C; CLASP1