pias3
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  • Official Full Name
  • protein inhibitor of activated STAT, 3
  • Background
  • This gene encodes a member of the PIAS (protein inhibitor of activated STAT (signal transducer and activator of;transcription)) family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like;modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It;directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced;transcript variants of this gene have been identified, but the full-length nature of some of these variants has not;been determined.
  • Synonyms
  • PIAS3; protein inhibitor of activated STAT, 3; E3 SUMO-protein ligase PIAS3; FLJ14651; zinc finger; MIZ type containing 5; ZMIZ5; zinc finger, MIZ-type containing 5; protein inhibitor of activated STAT protein 3
Cat.#:PIAS3-1245HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIAS3 protein, His & GST-tagged
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Cat.#:PIAS3-1704HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIAS3, GST-tagged
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Cat.#:PIAS3-12770MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PIAS3 Protein
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Cat.#:PIAS3-4443RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PIAS3 Protein
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Cat.#:PIAS3-3202HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIAS3 293 Cell Lysate
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Involved Pathway

PIAS3 involved in several pathways and played different roles in them. We selected most pathways PIAS3 participated on our site, such as Androgen receptor signaling pathway, C-MYB transcription factor network, Coregulation of Androgen receptor activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIAS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Androgen receptor signaling pathway
DAXX; CTNNB1; MYST2; RNF14; AES; PATZ1; RAD9A; KAT5; EGFR; JUN
C-MYB transcription factor network
CSF1R; MYC; CLTA; ADA; COL1A2; ADORA2B; PIAS3; MYF6; SLC25A3; SMARCA2
Coregulation of Androgen receptor activity
PIAS3; KDM4C; CTDSP1; SVIL; PA2G4; CARM1; KDM3A; TMF1; CMTM2A; PAWR
DNA Repair
BAZ1B; ZBTB32; TDP2B; USP10; POLI; EME2; EYA4; EME1; CHD1L; PPP4R2A
Formation of Incision Complex in GG-NER
CETN2; RNF111; DDB2; PARP2; PIAS3; CHD1L; DDB1; USP45
Global Genome Nucleotide Excision Repair (GG-NER)
CHD1L; USP45; YY1; INO80B; COPS6; INO80; PIAS3; DDB2; COPS5; PARP2
IL6-mediated signaling events
PIAS3; LMO4; CRP; JUNB
Interferon type I
GNB2L1; PIAS3

Protein Function

PIAS3 has several biochemical functions, for example, SUMO transferase activity, enzyme binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIAS3 itself. We selected most functions PIAS3 had, and list some proteins which have the same functions with PIAS3. You can find most of the proteins on our site.
Function
Related Protein
Function SUMO transferase activity
Related Protein UBE2IA; MUL1; UBE2I; PIAS3; SUMO4; PIAS4; CBX4; TOPORS; UBE2IB; NSMCE2
Function enzyme binding
Related Protein PTEN; YWHAH; CABYR; NOXA1; TAL1; YWHAE; PPP1R3B; APP; PARP4; TSPYL1
Function ligase activity
Related Protein RNF114; BRAP; IRF2BP1; SIAH1A; TRIM31; TRIM28; RLIM; HERC6; LNX1; SH3RF1
Function potassium channel regulator activity
Related Protein KCNIP1; PRKCZ; KCNE3; ARPP19; ANK2; LRRC26; KCNE2; KCNIP2; DPP6; KCNAB2
Function protein C-terminus binding
Related Protein IFT52; SHANK2; SDC1; MAP2K1; PIAS4; PDZD3; DGKZ; TAF13; RABAC1; SIAH1
Function protein N-terminus binding
Related Protein SMARCC1; HDAC1; KCNIP1; HESX1; RPS21; DCN; SYNGR3; EIF3E; TP53; MAU2
Function protein binding
Related Protein ERP44; LATS2; SYT2; HIST1H1E; MLLT4; ZKSCAN1; TLE3A; WASF2; TYR; AAAS
Function zinc ion binding
Related Protein TRIM35-21; POLR2K; AICDA; ZMYM2; ESRRGA; NEIL2; RUFY1; KLF4; MORC3; TCEA1

Interacting Protein

PIAS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIAS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIAS3.
MBD1; UBE2I; HNRNPK; GFI1; PRPF40A; SKIL; GLUL; UBA1; STAT3; yscQ; GEMIN4; PPP1CA; PSMC1; SATB1; CREM; SREBF2; q5ni67_fratt