pin1
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  • Official Full Name
  • peptidylprolyl cis/trans isomerase, NIMA-interacting 1
  • Background
  • The enzyme Peptidylprolyl isomerase (Pin1) is responsible for flipping the proline ring from the cis to trans conformation. This enzyme regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Pin1 is concentra
  • Synonyms
  • PIN1; peptidylprolyl cis/trans isomerase, NIMA-interacting 1; protein (peptidyl prolyl cis/trans isomerase) NIMA interacting 1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; dod; PPIase Pin1; rotamase Pin1; protein (peptidyl-prolyl cis/trans iso
Cat.#:PIN1-1722HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIN1, GST-tagged
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Cat.#:PIN1-2901HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIN1, T7-tagged
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Cat.#:PIN1-29590THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIN1, His-tagged
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Cat.#:PIN1-30964THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIN1
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Cat.#:PIN1-3825HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIN1, His tagged
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Cat.#:PIN1-3826HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIN1, None tagged
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Cat.#:Pin1-1167MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pin1 protein, His-tagged
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Cat.#:PIN1-12817MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PIN1 Protein
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Cat.#:PIN1-791CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus PIN1 Protein, His-tagged
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Cat.#:PIN1-11011ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PIN1
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Cat.#:PIN1-351HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Peptidylprolyl Cis/trans Isomerase, NIMA-interacting 1
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Cat.#:PIN1-3179HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PIN1 293 Cell Lysate
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Involved Pathway

PIN1 involved in several pathways and played different roles in them. We selected most pathways PIN1 participated on our site, such as RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
RIG-I-like receptor signaling pathway
IFNA4; IL12BA; DAK; DHX58; TRAF3; IFNW1; IRF3; NLRX1; IFNA14; MAPK10

Protein Function

PIN1 has several biochemical functions, for example, GTPase activating protein binding, mitogen-activated protein kinase kinase binding, peptidyl-prolyl cis-trans isomerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIN1 itself. We selected most functions PIN1 had, and list some proteins which have the same functions with PIN1. You can find most of the proteins on our site.
Function
Related Protein
Function GTPase activating protein binding
Related Protein PLCD1; GNAO1; GAPVD1; PIN1; TSC1; RGS14; PTBP3; TUBB; GNAI3; GNAI1
Function mitogen-activated protein kinase kinase binding
Related Protein MAP3K11; TRIB3; MAPK8IP3; TAOK2; TRIB1; PIN1; BRAF; RAF1; ACE; ARRB1
Function peptidyl-prolyl cis-trans isomerase activity
Related Protein PPIB; PIN1; FKBP1AB; PPIAL4B; FKBPL; PPIC; FKBP8; PPIF; PPIFA; FKBP1B
Function phosphoserine binding
Related Protein NEDD4; PIN1; YWHAB; YWHAE
Function phosphothreonine binding
Related Protein NEDD4; PIN1
Function protein binding
Related Protein SCGB2A2; CAP2; KIAA1737; NUMBL; KLC3; CXCR2; SYNJ2; NFKBIA; ESYT2; STX19

Interacting Protein

PIN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIN1.
TP53; ARHGAP8

PIN1 Related Articles

Yun, HJ; Kim, JY; et al. Prolyl-isomerase Pin1 Impairs Trastuzumab Sensitivity by Up-regulating Fatty Acid Synthase Expression. ANTICANCER RESEARCH 34:1409-1416(2014).
Driver, JA; Zhou, XZ; et al. Regulation of Protein Conformation by Pin1 Offers Novel Disease Mechanisms and Therapeutic Approaches in Alzheimer's Disease. DISCOVERY MEDICINE 92:93-99(2014).