Recombinant Full Length Human PIN1 Protein, C-Flag-tagged

• Cat.No.: PIN1-1058HFL
• Product Overview: Recombinant Full Length Human PIN1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 18.1 kDa
• AA Sequence: MADEEKLPPGWEKRMSRSSGRVYYF NHITNASQWERPSGNSSSGGKNGQG EPARVRCSHLLVKHSQSRRP SSWRQEKITRTKEEALELINGYIQK IKSGEEDFESLASQFSDCSSAKARG DLGAFSRGQMQKPFEDASFA
  LRTGEMSGPVFTDSGIHIILRTETR TRPLEQKLISEEDLAANDILDYKDD DDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: RIG-I-like receptor signaling pathway

Gene Information

• Gene Name: PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [ Homo sapiens (human) ]
• Official Symbol: PIN1
• Synonyms: DOD; UBL5
• Gene ID: 5300
• mRNA Refseq: NM_006221.4
• Protein Refseq: NP_006212.1
• MIM: 601052
• UniProt ID: Q13526