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Recombinant Mouse PIN1 Protein

Cat.No. : PIN1-12817M
Product Overview : Recombinant Mouse PIN1 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Mouse
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 ºC for short term. For long term storage, store it at -20 ºC~-80 ºC.
Storage Buffer : PBS buffer
Gene Name : Pin1 protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 [ Mus musculus ]
Official Symbol : PIN1
Gene ID : 23988
mRNA Refseq : NM_023371.3
Protein Refseq : NP_075860.1
MIM :
UniProt ID : Q9QUR7

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Are there therapeutic strategies targeting PIN1 for disease intervention? 01/22/2023

Yes, studies have explored the therapeutic potential of targeting PIN1 activity. Compounds inhibiting PIN1-mediated protein isomerization have shown promise as anticancer agents in preclinical studies. However, further research is needed to develop safe and effective therapeutic interventions.

How is the protein PIN1 involved in cancer development? 02/25/2021

An aberrant expression of PIN1 has been observed in various types of cancer. It has been found to contribute to cancer development by promoting cell proliferation, inhibiting apoptosis, and facilitating tumor angiogenesis. Additionally, PIN1 has been implicated in regulating the activity of oncogenes and tumor suppressor genes, further highlighting its involvement in cancer progression.

How does the protein PIN1 contribute to cellular processes? 08/05/2019

The protein PIN1 is a peptidyl-prolyl cis/trans isomerase that plays a critical role in regulating the conformational changes of phosphorylated proteins, particularly those involved in cell cycle progression, DNA damage response, and gene transcription. It mediates the isomerization of proline residues, thereby impacting protein stability, protein-protein interactions, and subcellular localization, influencing various cellular processes.

What molecular mechanisms contribute to the aberrant expression of PIN1 in various types of cancer? 06/09/2019

The abnormal expression of PIN1 in cancer can be attributed to several molecular mechanisms. One mechanism is the dysregulation of PIN1 transcription, often caused by genetic alterations or epigenetic modifications. Another mechanism involves the dysregulation of post-translational modifications that affect PIN1 protein stability and activity. Furthermore, upstream signaling pathways, such as growth factor signaling, can activate PIN1 expression. Additionally, oncogenic transcription factors and signaling cascades can directly or indirectly enhance PIN1 expression in cancer cells.

How does PIN1 regulate protein conformation? 05/27/2018

PIN1 exerts its regulatory function through the isomerization of proline residues that precede phosphorylated serine or threonine residues. This conformational change alters the stability, interactions, and localization of proteins, consequently influencing crucial cellular processes.

How does PIN1 regulate the activity of oncogenes and tumor suppressor genes in cancer? 03/04/2018

PIN1 interacts with oncogenes and tumor suppressor genes at various levels to modulate their activity. PIN1 mainly exerts its effect through protein isomerization, which can induce conformational changes in target proteins. PIN1 can stabilize oncogenic proteins or promote their degradation, thus affecting their activity. Similarly, PIN1 can modify the conformation of tumor suppressor proteins, leading to altered protein interactions and functional outcomes. By regulating the activity of these key players, PIN1 can influence the overall balance between oncogenic and tumor-suppressive signaling pathways in cancer cells.

What are the consequences of PIN1 dysregulation? 02/18/2017

Dysregulation of PIN1 has been associated with various diseases, including cancer, neurodegenerative disorders, and aging-related pathologies. Aberrant PIN1 activity can disrupt cellular signaling pathways, contribute to uncontrolled cell growth, and impair protein quality control mechanisms, leading to pathological conditions.

Customer Reviews (3)

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Reviews
09/21/2019

    Following the implementation of this protein reagent, the reproducibility of my experiments has significantly improved, leaving me highly satisfied.

    09/26/2017

      Approaching my research results with absolute confidence, this experimental reagent's high quality elevates my research expertise.

      02/25/2017

        The dilution effect of the reagent is excellent, providing a wide measurement range.

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