plscr1
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  • Official Full Name
  • Phospholipid Scramblase 1
  • Background
  • May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.
  • Synonyms
  • Ca(2+)-dependent phospholipid scramblase 1; PL scramblase 1; MMTRA1B; PLSCR1; Erythrocyte phospholipid scramblase; phospholipid scramblase 1; OTTHUMP00000215253; OTTHUMP00000215254; OTTHUMP00000215255; OTTHUMP00000215311; OTTHUMP00000215316
Cat.#:PLSCR1-1788HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLSCR1 protein, His & T7-tagged
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Cat.#:PLSCR1-1797HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLSCR1, GST-tagged
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Cat.#:PLSCR1-30296THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PLSCR1
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Cat.#:PLSCR1-354HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human phospholipid scramblase 1, His-tagged
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Cat.#:PLSCR1-12989MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PLSCR1 Protein
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Cat.#:PLSCR1-4534RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PLSCR1 Protein
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Cat.#:PLSCR1-3478RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PLSCR1 Protein, His-tagged
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Cat.#:PLSCR1-3096HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PLSCR1 293 Cell Lysate
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Involved Pathway

PLSCR1 involved in several pathways and played different roles in them. We selected most pathways PLSCR1 participated on our site, such as EGFR1 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLSCR1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
EGFR1 Signaling Pathway
WNK1; MTA2; ABI1; PITPNA; REPS1; EPPK1; STXBP1A; EPS8; USP6NL; ABI1B

Protein Function

PLSCR1 has several biochemical functions, for example, CD4 receptor binding, DNA binding, SH3 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLSCR1 itself. We selected most functions PLSCR1 had, and list some proteins which have the same functions with PLSCR1. You can find most of the proteins on our site.
Function
Related Protein
Function CD4 receptor binding
Related Protein LCK; SPG21; PLSCR1; PLSCR4; FYN
Function DNA binding
Related Protein GATA1; MYEF2; SNAPC3; HER7; FOXI3A; PKNOX1.1; HP1BP3; PPARAA; SOX1; LHFP
Function SH3 domain binding
Related Protein CD3E; SH3BGRL; ITM2B; ABI2; ADAM9; PDE4D; UVRAG; LRP2; SIRPA; ADAM19
Function calcium ion binding
Related Protein ANXA1B; EFCAB6; KCNIP1B; ZZEF1; STIM2; DLL1; CSN2; NID2; NELL1; PITPNM2
Function enzyme binding
Related Protein THRB; PDCD2; YWHAE; YWHAB; FAM84B; BCL10; SRC; CAT; CAV1; MSH3
Function epidermal growth factor receptor binding
Related Protein BTC; CBLC; RNF126; EREG; SNX1; TNK2; PLSCR1; HBEGFA; SOCS5; EPGN
Function phospholipid scramblase activity
Related Protein PLSCR1; ANO4; PLSCR4; PLSCR3B; PLSCR3A; ANO9; PLSCR3; PLSCR2; ANO6; ANO7
Function protein binding
Related Protein MSLN; ATP5B; SPANXA1; PIK3R2; TESK1; REG3A; HLX; GNB1; HAT1; TBX1
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein SMAD2; NKX2-8; NFKB2; CREB3; FOXJ2; PITX3; TFAM; NRL; EHF; FOXA1

Interacting Protein

PLSCR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLSCR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLSCR1.
GLRX3; EWSR1; DAZAP2; ILF3; polg_hcvco

PLSCR1 Related Articles

Kodigepalli, KM; Nanjundan, M; et al. Induction of PLSCR1 in a STING/IRF3-Dependent Manner upon Vector Transfection in Ovarian Epithelial Cells. PLOS ONE 10:-(2015).
Yuan, YZ; Tian, CY; et al. Interactome Map Reveals Phospholipid Scramblase 1 as a Novel Regulator of Hepatitis B Virus X Protein. JOURNAL OF PROTEOME RESEARCH 14:154-163(2015).