pms2
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  • Official Full Name
  • PMS2 postmeiotic segregation increased 2
  • Background
  • Microsatellite instability (MSI) is characterized by genome-wide alterations in short, repetitive DNA sequences. It is caused by defects in the nucleotide mismatch repair (MMR) system. Biologically, defective MMR results in a general increase in the mutat
  • Synonyms
  • PMS2; PMS2 postmeiotic segregation increased 2 (S. cerevisiae); PMSL2, postmeiotic segregation increased (S. cerevisiae) 2; mismatch repair endonuclease PMS2; H_DJ0042M02.9; HNPCC4; PMS1 protein homolog 2; DNA mismatch repair protein PMS2; PMSL2; PMS2CL
Cat.#:PMS2-1383HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PMS2 cell lysate
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Involved Pathway

PMS2 involved in several pathways and played different roles in them. We selected most pathways PMS2 participated on our site, such as Mismatch repair, Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PMS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Mismatch repair
PMS2; EXO1; RPA2; RFC3; MSH6; POLD4; LIG1; POLD2; RFC4; MLH3
Fanconi anemia pathway
FANCG; TOP3A; HES1; TOP3B; FANCA; UBE2T; RPA3; BRCA1; ATRIP; FANCF

Protein Function

PMS2 has several biochemical functions, for example, ATP binding, ATPase activity, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PMS2 itself. We selected most functions PMS2 had, and list some proteins which have the same functions with PMS2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein MYO10; WEE2; PRKACA; MB21D1; GM4922; RAD54B; THG1L; PAPSS2A; PRKCH; MAP2K4B
Function ATPase activity
Related Protein PSMD6; ABCE1; INO80; KIF3CB; EIF4A2; PMS2; ABCD3A; MLH1; KIF2B; ATAD1
Function DNA binding
Related Protein MND1; CREBZF; ZNF496; ZNF350; IMPDH1; DNMT3A; ZFP90; CERS3B; ZNF134; PURBA
Function contributes_to MutSalpha complex binding
Related Protein PMS2; MLH1
Function endonuclease activity
Related Protein ENDOG; NTHL1; PNKP; EAR4; FEN1; RSFR; PMS2; RNASE2; DROSHA; EAR1
Function protein binding
Related Protein SHC1; LAIR1; MRPL23; DNAJB1; TBX6; NPY1R; ATP5A1; Fzd4; GDI2; BRK1
Function single base insertion or deletion binding
Related Protein PMS2
Function contributes_to single-stranded DNA binding
Related Protein IGJ; POLR2D; MSH3; PMS2; MLH1; MSH2; IGHM

Interacting Protein

PMS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PMS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PMS2.
MLH1; BRIP1; FSCN1; ZNF189; RASA1; XPA; AKT1; PPP2CB

PMS2 Related Articles

Roth, RM; Hampel, H; et al. A Modified Lynch Syndrome Screening Algorithm in Colon Cancer BRAF Immunohistochemistry Is Efficacious and Cost Beneficial. AMERICAN JOURNAL OF CLINICAL PATHOLOGY 143:336-343(2015).
Muro, Y; Nakashima, R; et al. Autoantibodies to DNA Mismatch Repair Enzymes in Polymyositis/Dermatomyositis and Other Autoimmune Diseases: A Possible Marker of Favorable Prognosis. ARTHRITIS & RHEUMATOLOGY 66:3457-3462(2014).