pnpt1
Share
  • Official Full Name
  • polyribonucleotide nucleotidyltransferase 1
  • Background
  • PNPT1 is a subunit of the exosome complex, which is involved in 3-prime-to-5-prime exoribonuclease activity for RNA;processing and degradation (Raijmakers et al., 2002 (PubMed 12419256)).
  • Synonyms
  • PNPT1; polyribonucleotide nucleotidyltransferase 1; polyribonucleotide nucleotidyltransferase 1, mitochondrial; 3 5 RNA exonuclease; old 35; OLD35; PNPase; polynucleotide phosphorylase; PNPase 1; Polynucleotide phosphorylase like protein; PNPase old-35; 3-5 RNA exonuclease OLD35; polynucleotide phosphorylase 1; polynucleotide phosphorylase-like protein; old-35
Cat.#:PNPT1-1821HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PNPT1, GST-tagged
+Inquiry
Cat.#:PNPT1-13049MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PNPT1 Protein
+Inquiry
Cat.#:PNPT1-8099ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PNPT1
+Inquiry
Cat.#:PNPT1-1386HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PNPT1 cell lysate
+Inquiry

Involved Pathway

PNPT1 involved in several pathways and played different roles in them. We selected most pathways PNPT1 participated on our site, such as Purine metabolism, Pyrimidine metabolism, RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNPT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
PAPSS2; ADCY1B; GUCY2E; DGUOK; POLR2E; POLR2L; PRPS1L1; GUK1; NT5C3L; POLR1A
Pyrimidine metabolism
NT5C1B-RDH14; TK2; POLE; POLE4; PRIM1; POLR2A; DPYS; POLR2L; TK1; PRIM2
RNA degradation
TOB1A; PAN2; CNOT6; CNOT3B; PNPT1; DCP1B; PABPC1B; CNOT8; TOB2; PABPC1A

Protein Function

PNPT1 has several biochemical functions, for example, 3-5-exoribonuclease activity, miRNA binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PNPT1 itself. We selected most functions PNPT1 had, and list some proteins which have the same functions with PNPT1. You can find most of the proteins on our site.
Function
Related Protein
Function 3-5-exoribonuclease activity
Related Protein USB1; EXOSC4; SMFN; ERI1; PNPT1; ERI2; CNOT8; DIS3L; EXOSC2; ERI3
Function miRNA binding
Related Protein DICER1; AGO1; PNPT1; RBM4; SOX2; POU5F1; TRIM71; EIF2C3; LIN28A; AGO3
Function poly(A) RNA binding
Related Protein MBNL3; NDUFV3; NCBP2; SERPINH1; RPL5; TCERG1; RPL3; RSL24D1; CSTF1; GTPBP1
Function poly(G) binding
Related Protein HNRPDL; PATL2; PATL1; PNPT1; HNRNPDL
Function poly(U) RNA binding
Related Protein HNRNPC; KHDRBS2; PATL1; PNPT1; RBM11; KHDRBS1; MSI2; PATL2; PABPC4; PABPC1
Function polyribonucleotide nucleotidyltransferase activity
Related Protein PNPT1
Function protein binding
Related Protein TSPAN12; CARD9; BTK; LRRC25; CDK5R2; ENTPD3; UNKL; NRCAM; AGXT2L2; CCR1

Interacting Protein

PNPT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNPT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PNPT1.
MCC; TRAF6; HSPB1; LTN1; ICT1