Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

PNPT1

Official Full Name

polyribonucleotide nucleotidyltransferase 1
Overview

PNPT1 is a subunit of the exosome complex, which is involved in 3-prime-to-5-prime exoribonuclease activity for RNA;processing and degradation (Raijmakers et al., 2002 (PubMed 12419256)).
Synonyms

PNPT1; polyribonucleotide nucleotidyltransferase 1; polyribonucleotide nucleotidyltransferase 1, mitochondrial; 3 5 RNA exonuclease; old 35; OLD35; PNPase; polynucleotide phosphorylase; PNPase 1; Polynucleotide phosphorylase like protein; PNPase old-35; 3-5 RNA exonuclease OLD35; polynucleotide phosphorylase 1; polynucleotide phosphorylase-like protein; old-35;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PNPT1-1821H	Recombinant Human PNPT1, GST-tagged	E.coli	GST	427-783aa	$319 / 25ug
Human	PNPT1-1386HCL	Recombinant Human PNPT1 cell lysate		N/A		Inquiry
Mouse	PNPT1-13049M	Recombinant Mouse PNPT1 Protein	Mammalian Cell	His		Inquiry
Mouse	PNPT1-6894M	Recombinant Mouse PNPT1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	PNPT1-6894M-B	Recombinant Mouse PNPT1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	PNPT1-8099Z	Recombinant Zebrafish PNPT1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

PNPT1 involved in several pathways and played different roles in them. We selected most pathways PNPT1 participated on our site, such as Purine metabolism, Pyrimidine metabolism, RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNPT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Purine metabolism	NPR2;AK9;PRPS1;PDE1C;POLR3E;PDE6A;PDE5AB;NME4;NT5C1AA
Pyrimidine metabolism	UCK1;TXNRD1;PNP5A;NUDT2;CMPK2;AK9;POLR2K;POLR2D;ENTPD1
RNA degradation	MPHOSPH6;ENO3;ENO2;CNOT6;PATL1;CNOT6L;ZCCHC7;DIS3L;EXOSC3

PNPT1 has several biochemical functions, for example, 3-5-exoribonuclease activity, miRNA binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PNPT1 itself. We selected most functions PNPT1 had, and list some proteins which have the same functions with PNPT1. You can find most of the proteins on our site.

Function	Related Protein
3-5-exoribonuclease activity	C16orf57;CNOT8;CNOT7;EXOSC4;SMFN;EXOSC3;EXOSC2;DIS3L;REXO2
miRNA binding	RBM4;SOX2;TRIM71;AGO4;MEF2C;AGO1;AGO2;PNPT1;LIN28A
poly(A) RNA binding	RPP30;TRIM28;C1orf131;HNRNPC;UBE2O;NCL;XRN2;HSP90AA1;FNDC3A
poly(G) binding	HNRNPDL;PNPT1;PATL1;HNRPDL;PATL2
poly(U) RNA binding	PATL2;DIS3L2;MSI1;PABPC1;MSI2;KHDRBS2;PABPC4;PNPT1;KHDRBS1
polyribonucleotide nucleotidyltransferase activity
protein binding	KDM5A;TAX1BP3;GCKR;TUBGCP3;UBE2Q1;JIP1;MRPL1;ELOVL6;ZNF559

PNPT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNPT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PNPT1.

MCC; TRAF6; HSPB1; LTN1; ICT1