polr1d
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  • Official Full Name
  • polymerase (RNA) I polypeptide D, 16kDa
  • Background
  • The protein encoded by this gene is a component of the RNA polymerase I and RNA polymerase III complexes, which function in the synthesis of ribosomal RNA precursors and small RNAs, respectively. Mutations in this gene are a cause of Treacher Collins syndrome (TCS), a craniofacial development disorder. Alternative splicing results in multiple transcript variants.
  • Synonyms
  • POLR1D; polymerase (RNA) I polypeptide D, 16kDa; DNA-directed RNA polymerases I and III subunit RPAC2; MGC9850; RPA9; RPA16; RPAC2; RPO1 3; FLJ20616; POLR1C; AC19; DNA directed RNA polymerase I 16 kDa polypeptide; DNA directed RNA polymerase I subunit D; DNA directed RNA polymerases I and III subunit RPAC2; DNA-directed RNA polymerase I subunit D; hRPA19; Polymerase (RNA) I polypeptide D; RNA polymerase I 16 kDa subunit; RNA polymerases I and III subunit AC2; RPAC2_HUMAN; RPC16; OTTHUMP00000018172; TCS2; RPO1-3
Cat.#:POLR1D-1839HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLR1D, GST-tagged
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Cat.#:POLR1D-13089MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse POLR1D Protein
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Cat.#:POLR1D-3512RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey POLR1D Protein, His-tagged
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Cat.#:POLR1D-1175ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish POLR1D
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Cat.#:POLR1D-3039HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human POLR1D 293 Cell Lysate
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Cat.#:POLR1D-3040HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human POLR1D 293 Cell Lysate
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Involved Pathway

POLR1D involved in several pathways and played different roles in them. We selected most pathways POLR1D participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR1D were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
POLA2; IMPDH1; ALLC; AK1; PRIM1; GMPR; PDE6G; AMPD3B; POLR2A; TWISTNB
Pyrimidine metabolism
POLR2C; POLD2; NT5C3A; PNP; POLR2G; POLR3A; PNP5A; DTYMK; DCK; CTPS2
Metabolic pathways
CYP21A1; DMGDH; AOC3; CKMT1; NAMPTB; MECR; GCSHA; MAN1A1; INPP5KA; B3GNT5A
RNA polymerase
POLR1E; POLR2J; POLR2D; POLR2H; POLR2K; POLR2J3; POLR2L; POLR2I; POLR3GLB; POLR2F
Cytosolic DNA-sensing pathway
IFNA17; IKBKE; IFNA10; Ifna11; POLR3C; POLR3D; CASP1; IL33; IFNA7; IFNB
Epstein-Barr virus infection
IKBKG; H2-Q10; YWHAB; EIF2AK2; TRADD; HLA-DPA1; GTF2E2; PIK3CA; PRKACB; GTF2E1

Protein Function

POLR1D has several biochemical functions, for example, DNA binding, contributes_to RNA polymerase I activity, contributes_to RNA polymerase III activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR1D itself. We selected most functions POLR1D had, and list some proteins which have the same functions with POLR1D. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein MECP2; HIST1H2AF; ZNF684; AKNA; PURBA; MIER1B; THAP6; NFE2L2B; TET2; KLF5
Function contributes_to RNA polymerase I activity
Related Protein POLR1D; POLR2H; POLR2E; POLR1A; ZNRD1; POLR2L; POLR1C; POLR1E; POLR2F; POLR2K
Function contributes_to RNA polymerase III activity
Related Protein CRCP; POLR2H; POLR3B; POLR2K; POLR2L; POLR1D; POLR3GLB; POLR3E; POLR2E; POLR3GLA
Function protein binding
Related Protein CA8; RAB18; PPP2R5C; BAG4; FAM207A; RFC2; ATF6; TBC1D17; RAMP1; TGFBRAP1
Function protein dimerization activity
Related Protein NEUROG2; NHLH2; MESPAA; MITFA; HER6; HER1; MTOR; DERL3; HNF1A; GARS

Interacting Protein

POLR1D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR1D here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR1D.
POLR1C; POLR1A; NFKBIB; HAX1; DNAJB6; NR3C1; CDC25A; DDIT3; MAGEA11; CRKL; PXN; MRPL12; GRB2

POLR1D Related Articles

Giampietro, PF; Armstrong, L; et al. Whole Exome Sequencing Identifies a POLRID Mutation Segregating in a Father and Two Daughters with Findings of Klippel-Feil and Treacher Collins Syndromes. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 167A:95-102(2015).
Schaefer, E; Collet, C; et al. Autosomal recessive POLR1D mutation with decrease of TCOF1 mRNA is responsible for Treacher Collins syndrome. GENETICS IN MEDICINE 16:720-724(2014).