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POLR1D

  • Official Full Name

    polymerase (RNA) I polypeptide D, 16kDa

  • Overview

    The protein encoded by this gene is a component of the RNA polymerase I and RNA polymerase III complexes, which function in the synthesis of ribosomal RNA precursors and small RNAs, respectively. Mutations in this gene are a cause of Treacher Collins syndrome (TCS), a craniofacial development disorder. Alternative splicing results in multiple transcript variants.
  • Synonyms

    POLR1D; polymerase (RNA) I polypeptide D, 16kDa; DNA-directed RNA polymerases I and III subunit RPAC2; MGC9850; RPA9; RPA16; RPAC2; RPO1 3; FLJ20616; POLR1C; AC19; DNA directed RNA polymerase I 16 kDa polypeptide; DNA directed RNA polymerase I subunit D; DNA directed RNA polymerases I and III subunit RPAC2; DNA-directed RNA polymerase I subunit D; hRPA19; Polymerase (RNA) I polypeptide D; RNA polymerase I 16 kDa subunit; RNA polymerases I and III subunit AC2; RPAC2_HUMAN; RPC16; OTTHUMP00000018172; TCS2; RPO1-3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human POLR1D-1839H Recombinant Human POLR1D, GST-tagged E.coli GST 1-133aa
Human POLR1D-3039HCL Recombinant Human POLR1D 293 Cell Lysate HEK293 N/A
Human POLR1D-3040HCL Recombinant Human POLR1D 293 Cell Lysate HEK293 N/A
Human POLR1D-1838H Recombinant Human POLR1D Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse POLR1D-13089M Recombinant Mouse POLR1D Protein Mammalian Cell His
Mouse Polr1d-4994M Recombinant Mouse Polr1d Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse POLR1D-6919M Recombinant Mouse POLR1D Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse POLR1D-6919M-B Recombinant Mouse POLR1D Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque POLR1D-3512R Recombinant Rhesus monkey POLR1D Protein, His-tagged Mammalian Cell His
Rhesus Macaque POLR1D-3330R Recombinant Rhesus Macaque POLR1D Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque POLR1D-3330R-B Recombinant Rhesus Macaque POLR1D Protein Pre-coupled Magnetic Beads HEK293
Zebrafish POLR1D-1175Z Recombinant Zebrafish POLR1D Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • POLR1D Related Articles

POLR1D involved in several pathways and played different roles in them. We selected most pathways POLR1D participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR1D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismPOLE4;NME6;PDE6C;UOX;AMPD3B;CANT1;POLR2L;POLR2I;AK2
Pyrimidine metabolismDUT;TXNRD1;CAD;POLR2E;DPYD;POLR1E;POLR3K;CTPS2;CMPK1
Metabolic pathwaysTPI1A;CYP26C1;HK2;LIPT1;GALNT7;ACSM2B;CYP2C55;TGDS;DCXR
RNA polymerasePOLR3GLB;POLR2K;POLR2F;POLR3A;POLR2J3;POLR1B;POLR2J2;POLR2I;POLR2GL
Cytosolic DNA-sensing pathwayPOLR2EB;IFNA7;Ifna11;POLR2F;CXCL10;CCL5;IFI202B;IKBKE;IFNB
Epstein-Barr virus infectionGTF2B;HSPA1B;PRKACG;DDX58;IRF3;TRADD;PIK3CD;NFKBIB;HLA-DQA1

POLR1D has several biochemical functions, for example, DNA binding, contributes_to RNA polymerase I activity, contributes_to RNA polymerase III activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR1D itself. We selected most functions POLR1D had, and list some proteins which have the same functions with POLR1D. You can find most of the proteins on our site.

Function Related Protein
DNA bindingLIG4;NFYC;CHTF18;ATM;PHTF2;NKX6.1;PPP1R10;HIST1H4C;CRY2
contributes_to RNA polymerase I activityPOLR2K;POLR1A;POLR1C;POLR2L;ZNRD1;POLR2EB;POLR2H;TWISTNB;POLR1D
contributes_to RNA polymerase III activityPOLR1C;POLR3GLB;POLR3G;POLR2K;POLR3F;POLR3GLA;POLR2E;POLR2H;POLR3E
protein bindingIWS1;EDC3;YY1AP1;MRPL20;FGF10;UBA52;PRDX3;COMMD10;FAM195B
protein dimerization activityMYCLA;HER4.2;SREBF2;MEF2CB;MYCA;POLR2C;MEF2AA;MYC;TCF3A

POLR1D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR1D here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR1D.

POLR1C; POLR1A; NFKBIB; HAX1; DNAJB6; NR3C1; CDC25A; DDIT3; MAGEA11; CRKL; PXN; MRPL12; GRB2

Giampietro, PF; Armstrong, L; et al. Whole Exome Sequencing Identifies a POLRID Mutation Segregating in a Father and Two Daughters with Findings of Klippel-Feil and Treacher Collins Syndromes. AMERICAN JOURNAL OF MEDICAL GENETICS PART A 167A:95-102(2015).
Schaefer, E; Collet, C; et al. Autosomal recessive POLR1D mutation with decrease of TCOF1 mRNA is responsible for Treacher Collins syndrome. GENETICS IN MEDICINE 16:720-724(2014).
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