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POLR2D

  • Official Full Name

    polymerase (RNA) II (DNA directed) polypeptide D

  • Overview

    This gene encodes the fourth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained within the 3 untranslated region of the transcript from this gene.
  • Synonyms

    POLR2D; polymerase (RNA) II (DNA directed) polypeptide D; DNA-directed RNA polymerase II subunit RPB4; RBP4; RNA polymerase II subunit hsRBP4; DNA-directed RNA polymerase II 16 kDa polypeptide; DNA-directed RNA polymerase II subunit D; HSRBP4; polymerase RNA II DNA directed polypeptide D; RNA polymerase II subunit B4; RNA polymerase II subunit D; OTTHUMP00000162266; OTTHUMP00000203872; OTTHUMP00000205986; RNA polymerase II 16 kDa subunit; DNA-directed RNA p; RPB16; HSRPB4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human POLR2D-15909H Recombinant Human POLR2D, His-tagged E.coli His 1-142aa
Human POLR2D-1842H Recombinant Human POLR2D, His-tagged E.coli His 1-142aa
Human POLR2D-3035HCL Recombinant Human POLR2D 293 Cell Lysate HEK293 N/A
Mouse POLR2D-13094M Recombinant Mouse POLR2D Protein Mammalian Cell His
Mouse POLR2D-6922M-B Recombinant Mouse POLR2D Protein Pre-coupled Magnetic Beads HEK293
Mouse Polr2d-4996M Recombinant Mouse Polr2d Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse POLR2D-6922M Recombinant Mouse POLR2D Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque POLR2D-3515R Recombinant Rhesus monkey POLR2D Protein, His-tagged Mammalian Cell His
Rhesus Macaque POLR2D-3333R Recombinant Rhesus Macaque POLR2D Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque POLR2D-3333R-B Recombinant Rhesus Macaque POLR2D Protein Pre-coupled Magnetic Beads HEK293
Zebrafish POLR2D-466Z Recombinant Zebrafish POLR2D Mammalian Cell His
Chicken POLR2D-4813C Recombinant Chicken POLR2D Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • POLR2D Related Articles

POLR2D involved in several pathways and played different roles in them. We selected most pathways POLR2D participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR2D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismNME6;NT5C1BA;UOX;NT5C2A;NT5C1B-RDH14;NT5C1A;PGM2;PDE4B;GMPS
Pyrimidine metabolismUPP2;NME2B.1;NT5C2B;DPYD;ITPA;CAD;UCK2;UCK1;NME7
Metabolic pathwaysSGMS1;ASL;PAFAH1B2;GCSHB;SDHB;GCSHA;NMNAT2;NDUFA3;GALNT10
RNA polymerasePOLR2EB;POLR3GL;POLR1A;ZNRD1;POLR1C;POLR2A;POLR3B;POLR2J2;POLR2H
Huntingtons diseaseHDAC2;DNALC1;ATP5G3;NDUFAB1;DNAH6;NDUFB11;POLR2J;NDUFS4;mt-Atp8
Epstein-Barr virus infectionCD19;IFNG;TAB1;GTF2E1;PSMC4;POLR2E;HLA-DQA1;TYK2;ITGAL

POLR2D has several biochemical functions, for example, DNA-directed RNA polymerase activity, nucleotide binding, contributes_to single-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR2D itself. We selected most functions POLR2D had, and list some proteins which have the same functions with POLR2D. You can find most of the proteins on our site.

Function Related Protein
DNA-directed RNA polymerase activityPOLR3G;MED21;CD3EAP;POLRMT;POLR1C;POLR3H;POLR3C;POLR2I;POLR2L
nucleotide bindingUMPS;EIF2S3Y;RBM42;PRKCHB;HNRNPL;ZNF143B;CMPK;RBPMS2;RBM34
contributes_to single-stranded DNA bindingIGHM;MSH3;MLH1;PMS2;MSH2;POLR2D;IGJ
contributes_to single-stranded RNA binding
translation initiation factor bindingEIF2B4;LIN28A;DDX3X;TBL2;POLR2GL;EIF3BA;EIF3F;POLR2D;EIF3B

POLR2D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR2D here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR2D.

MED19; MED26; POLR2L; RBBP6; ssdna_dc; SUPT5H; LIMK1; POLR2G; CTR9; Med28; MED10; Rprd1b; MED9; MED29

Goede, B; Naji, S; et al. Protein-protein interactions in the archaeal transcriptional machinery - Binding studies of isolated RNA polymerase subunits and transcription factors. JOURNAL OF BIOLOGICAL CHEMISTRY 281:30581-30592(2006).
Ren, YG; Martinez, J; et al. Identification of the active site of poly(A)-specific ribonuclease by site-directed mutagenesis and Fe2+-mediated cleavage. JOURNAL OF BIOLOGICAL CHEMISTRY 277:5982-5987(2002).
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