polr2d
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  • Official Full Name
  • polymerase (RNA) II (DNA directed) polypeptide D
  • Background
  • This gene encodes the fourth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained within the 3 untranslated region of the transcript from this gene.
  • Synonyms
  • POLR2D; polymerase (RNA) II (DNA directed) polypeptide D; DNA-directed RNA polymerase II subunit RPB4; RBP4; RNA polymerase II subunit hsRBP4; DNA-directed RNA polymerase II 16 kDa polypeptide; DNA-directed RNA polymerase II subunit D; HSRBP4; polymerase RNA II DNA directed polypeptide D; RNA polymerase II subunit B4; RNA polymerase II subunit D; OTTHUMP00000162266; OTTHUMP00000203872; OTTHUMP00000205986; RNA polymerase II 16 kDa subunit; DNA-directed RNA p; RPB16; HSRPB4
Cat.#:POLR2D-15909HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLR2D, His-tagged
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Cat.#:POLR2D-1842HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human POLR2D, His-tagged
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Cat.#:POLR2D-13094MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse POLR2D Protein
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Cat.#:POLR2D-3515RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey POLR2D Protein, His-tagged
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Cat.#:POLR2D-4813CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken POLR2D
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Cat.#:POLR2D-466ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish POLR2D
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Cat.#:POLR2D-3035HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human POLR2D 293 Cell Lysate
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Involved Pathway

POLR2D involved in several pathways and played different roles in them. We selected most pathways POLR2D participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR2D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
DCK; AMPD2; POLR3C; NTPCR; XDH; IMPDH1; PFAS; ADCY2B; NME2B.2; PDE8A
Pyrimidine metabolism
ENTPD3; TYMS; PRIM2; UCK2B; POLD2; POLE2; CTPS2; POLD1; CAD; NME2A
Metabolic pathways
CMASA; PIGQ; PIGU; CYP1A; DCXR; DGUOK; NME2B.1; PCYT2; LPIN1; ACSL3B
RNA polymerase
POLR3A; POLR3D; POLR1A; POLR3GL; POLR2D; POLR2G; POLR1C; POLR2L; POLR2F; POLR2GL
Huntingtons disease
NDUFC1; COX6A2; ATP5J; PLCB4; COX7A2; GNAQ; POLR2J2; HTT; UQCR11; POLR2L
Epstein-Barr virus infection
POLR3F; PSMC4; MAP2K7; XPO1; POLR3C; HLA-G; SHFM1; POLR3D; HLA-A; STAT3

Protein Function

POLR2D has several biochemical functions, for example, DNA-directed RNA polymerase activity, nucleotide binding, contributes_to single-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR2D itself. We selected most functions POLR2D had, and list some proteins which have the same functions with POLR2D. You can find most of the proteins on our site.
Function
Related Protein
Function DNA-directed RNA polymerase activity
Related Protein POLR3A; POLR2D; CCDC111; POLR2B; RPAP1; POLR3C; PRIM2; POLRMT; POLR2EB; POLR2M
Function nucleotide binding
Related Protein SNRPB2; SAR1AB; GIMAP3; PFKMB; ORC4; SAFB2; RAF1B; RCAN2; SRSF1B; VDAC2
Function contributes_to single-stranded DNA binding
Related Protein PMS2; IGHM; POLR2D; MSH2; IGJ; MLH1; MSH3
Function contributes_to single-stranded RNA binding
Related Protein POLR2D
Function translation initiation factor binding
Related Protein POLR2G; ZFP259; EIF2B4; EIF2B3; DDX3X; EIF3C; LIN28A; EIF2B5; TBL2; TRIM32

Interacting Protein

POLR2D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR2D here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR2D.
MED19; MED26; POLR2L; RBBP6; ssdna_dc; SUPT5H; LIMK1; POLR2G; CTR9; Med28; MED10; Rprd1b; MED9; MED29

POLR2D Related Articles

Goede, B; Naji, S; et al. Protein-protein interactions in the archaeal transcriptional machinery - Binding studies of isolated RNA polymerase subunits and transcription factors. JOURNAL OF BIOLOGICAL CHEMISTRY 281:30581-30592(2006).
Ren, YG; Martinez, J; et al. Identification of the active site of poly(A)-specific ribonuclease by site-directed mutagenesis and Fe2+-mediated cleavage. JOURNAL OF BIOLOGICAL CHEMISTRY 277:5982-5987(2002).