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POLR2D

Official Full Name

polymerase (RNA) II (DNA directed) polypeptide D
Overview

This gene encodes the fourth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained within the 3 untranslated region of the transcript from this gene.
Synonyms

POLR2D; polymerase (RNA) II (DNA directed) polypeptide D; DNA-directed RNA polymerase II subunit RPB4; RBP4; RNA polymerase II subunit hsRBP4; DNA-directed RNA polymerase II 16 kDa polypeptide; DNA-directed RNA polymerase II subunit D; HSRBP4; polymerase RNA II DNA directed polypeptide D; RNA polymerase II subunit B4; RNA polymerase II subunit D; OTTHUMP00000162266; OTTHUMP00000203872; OTTHUMP00000205986; RNA polymerase II 16 kDa subunit; DNA-directed RNA p; RPB16; HSRPB4;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	POLR2D-15909H	Recombinant Human POLR2D, His-tagged	E.coli	His	1-142aa	Inquiry
Human	POLR2D-1842H	Recombinant Human POLR2D, His-tagged	E.coli	His	1-142aa	$319 / 25ug
Human	POLR2D-3035HCL	Recombinant Human POLR2D 293 Cell Lysate	HEK293	N/A		Inquiry
Mouse	POLR2D-13094M	Recombinant Mouse POLR2D Protein	Mammalian Cell	His		Inquiry
Mouse	POLR2D-6922M-B	Recombinant Mouse POLR2D Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Polr2d-4996M	Recombinant Mouse Polr2d Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	POLR2D-6922M	Recombinant Mouse POLR2D Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	POLR2D-3515R	Recombinant Rhesus monkey POLR2D Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	POLR2D-3333R	Recombinant Rhesus Macaque POLR2D Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	POLR2D-3333R-B	Recombinant Rhesus Macaque POLR2D Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	POLR2D-466Z	Recombinant Zebrafish POLR2D	Mammalian Cell	His		Inquiry
Chicken	POLR2D-4813C	Recombinant Chicken POLR2D	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
POLR2D Related Articles

POLR2D involved in several pathways and played different roles in them. We selected most pathways POLR2D participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLR2D were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Purine metabolism	IMPDH2;ENTPD6;NT5C1B-RDH14;NUDT9;NT5C3L;POLR2L;PDE4A;CANT1A;POLA2
Pyrimidine metabolism	RRM2;POLE3;ZNRD1;POLA2;POLD1;POLR1B;NT5C1B-RDH14;TRR1;POLR2A
Metabolic pathways	DGKD;PNLIPRP2;LSM1;ybaS;ATP6V1G3;NDUFA8;SCP2A;NDUFB6;PRDX6
RNA polymerase	POLR2J3;POLR2L;ZNRD1;POLR2K;POLR3GLB;POLR2J2;POLR2H;POLR2GL;POLR2A
Huntingtons disease	DNAI2;POLR2J3;SLC25A5;NDUFA10;DNALC1;TRP53;GRM5;RCOR1;SLC25A31
Epstein-Barr virus infection	IL10RA;IKBKG;PLCG2;PIK3CB;IRF3;RB1;POLR2A;TNFAIP3;POLR2K

POLR2D has several biochemical functions, for example, DNA-directed RNA polymerase activity, nucleotide binding, contributes_to single-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLR2D itself. We selected most functions POLR2D had, and list some proteins which have the same functions with POLR2D. You can find most of the proteins on our site.

Function	Related Protein
DNA-directed RNA polymerase activity	MED20;POLR2J;POLR2E;POLR3K;POLR2B;POLR2EB;POLR2I;PRIM2;CD3EAP
nucleotide binding	GLULA;MSI2B;ABCC5;SCAF8;CIRBP;TUBA4L;HNRPL;ATP2B2;RAB5AA
contributes_to single-stranded DNA binding	PMS2;IGJ;MSH3;IGHM;MLH1;MSH2;POLR2D
contributes_to single-stranded RNA binding
translation initiation factor binding	LIN28A;EIF3BA;ZFP259;EIF2B4;ZNF259;EIF3F;EIF2B3;POLR2G;POLR2D

POLR2D has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLR2D here. Most of them are supplied by our site. Hope this information will be useful for your research of POLR2D.

MED19; MED26; POLR2L; RBBP6; ssdna_dc; SUPT5H; LIMK1; POLR2G; CTR9; Med28; MED10; Rprd1b; MED9; MED29

Goede, B; Naji, S; et al. Protein-protein interactions in the archaeal transcriptional machinery - Binding studies of isolated RNA polymerase subunits and transcription factors. JOURNAL OF BIOLOGICAL CHEMISTRY 281:30581-30592(2006).

Ren, YG; Martinez, J; et al. Identification of the active site of poly(A)-specific ribonuclease by site-directed mutagenesis and Fe2+-mediated cleavage. JOURNAL OF BIOLOGICAL CHEMISTRY 277:5982-5987(2002).