pon3
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  • Official Full Name
  • paraoxonase 3
  • Background
  • This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]
  • Synonyms
  • PON3; paraoxonase 3; serum paraoxonase/lactonase 3; paraoxanase-3; arylesterase 3;
Cat.#:PON3-27HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PON3, His-tagged
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Cat.#:PON3-594HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PON3 protein, His-tagged
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Cat.#:PON3-13123MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PON3 Protein
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Cat.#:PON3-4579RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PON3 Protein
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Cat.#:PON3-3018ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PON3
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Cat.#:PON3-467HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PON3 cell lysate
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Involved Pathway

PON3 involved in several pathways and played different roles in them. We selected most pathways PON3 participated on our site, such as Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PON3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolic pathways
LPCAT4; HIBCH; AKR1A1A; UAP1; ADPGK; ATP5A1; DHCR7; PC; GFPT2; NMRK2

Protein Function

PON3 has several biochemical functions, for example, 3,4-dihydrocoumarin hydrolase activity, aryldialkylphosphatase activity, arylesterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PON3 itself. We selected most functions PON3 had, and list some proteins which have the same functions with PON3. You can find most of the proteins on our site.
Function
Related Protein
Function 3,4-dihydrocoumarin hydrolase activity
Related Protein LIPM; PNPLA7; ABHD2B; Aadacl3; LIPK; DAGLB; PON3; CES1C; CELL; Cel
Function aryldialkylphosphatase activity
Related Protein PON1; PON3
Function arylesterase activity
Related Protein CA2; PON2; APMAP; PON1; C20orf3; Car2; PON3; CAR1; CA1
Function dihydrocoumarin hydrolase activity
Related Protein PON3
Function metal ion binding
Related Protein TRIT1; ME2; ARID2; ZNF543; ZC3H15; RNF34A; ZFP354B; BMX; RARAA; KDM6A
Function protein homodimerization activity
Related Protein BCL2L10; SLC9A7; MIXL1; DNTTIP1; LSM1; RRAGA; APOBEC3G; MLL1; TP53I3; TFRC

Interacting Protein

PON3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PON3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PON3.
q9wmx2-pro_0000037550; d-mannose

PON3 Related Articles

Rull, A; Garcia, R; et al. Serum paraoxonase-3 concentration is associated with insulin sensitivity in peripheral artery disease and with inflammation in coronary artery disease. ATHEROSCLEROSIS 220:545-551(2012).
Garcia-Heredia, A; Marsillach, J; et al. Serum paraoxonase-3 concentration is associated with the severity of hepatic impairment in patients with chronic liver disease. CLINICAL BIOCHEMISTRY 44:1320-1324(2011).