PREP
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Official Full Name
Prolyl endopeptidase
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Overview
Proline specific endopeptidase, isolated from Flavobacterium sp., cleaves specifically the peptide bonds on the carboxy side of proline residues1,2. This enzyme is very close, in its properties, to a post-proline cleaving enzyme3-5. The substrates have been found to have the general structure Y-Pro-X, where Y is a peptide or N-protected amino acid and X may be an amino acid, peptide, amide or ester. Much slower hydrolysis is observed when the substrate is Y-Ala-X5. -
Synonyms
Prolyl endopeptidase; Post-proline cleaving enzyme; Post-proline endopeptidase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Insect Cells
- Mammalian Cell
- Sf21 Insect Cell
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- PREP Related Articles
- PREP Related Research Area
PREP involved in several pathways and played different roles in them. We selected most pathways PREP participated on our site, such as Renin-angiotensin system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PREP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Renin-angiotensin system | KLK1;ENPEP;ACE2;LNPEP;AGTR1B;KLK1B9;KLK1B26;REN2;KLK1B8 |
PREP has several biochemical functions, for example, protein binding, serine-type endopeptidase activity, serine-type exopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PREP itself. We selected most functions PREP had, and list some proteins which have the same functions with PREP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PEBP1;AK3;ANO6;MLANA;GBP5;C9orf9;SNX20;CUEDC2;ZMAT4 |
| serine-type endopeptidase activity | GM5077;CFB;EGFBP2;PRSS40;KLK14;F9;PRSS57;CTRB1;KLKB1 |
| serine-type exopeptidase activity | HPN;PREP;PREPL |
| serine-type peptidase activity | FAP;PRSS48;PRSS40;F7;KLK1B8;DPP6B;TRY;ST14A;KLK1B5 |
PREP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PREP here. Most of them are supplied by our site. Hope this information will be useful for your research of PREP.
GAPDH; HLA-B; PRKAB1; TRAF6; SUCO
- Q&As
- Reviews
Q&As (6)
Ask a questionThe protein may be involved in cardiovascular disease, but the specific mechanism is not fully understood, and further research is needed to validate it.
PREP protein has been implicated in several diseases, including neurological disorders such as Alzheimer's disease, stroke, and Parkinson's disease.
Some studies suggest that PREP protein may be involved in the development of neurodegenerative diseases, but the specific mechanism and effects need to be further studied.
Studies have shown that PREP protein is abnormally expressed in some tumors, which may be related to the development and progression of tumors, but the specific role still needs to be further studied.
The role of PREP protein in digestive diseases is currently limited, and more research is needed to further explore its role and potential applications.
PREP protein can participate in the regulation of protein folding and aggregation, so it may have potential in the prevention of protein aggregation diseases.
Customer Reviews (3)
Write a reviewThe safety is very high, so you can use it with confidence.
PREP activity is maintained for a very long time and can be maintained for a long time.
It is very resistant to pollution and is not easily polluted.
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