PPP1R12A Protein, protein phosphatase 1, regulatory subunit 12A


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Official Full Name protein phosphatase 1, regulatory subunit 12A
Background Protein phosphatase 1 (PP1) is a ubiquitous eukaryotic protein serine/threonine phosphatase involved in the regulation of various cell functions. Substrate specificity is determined by the binding of a regulatory subunit to the PP1 catalytic subunit (PP1c
Synonyms PPP1R12A; protein phosphatase 1, regulatory subunit 12A; MYPT1, protein phosphatase 1, regulatory (inhibitor) subunit 12A; protein phosphatase 1 regulatory subunit 12A; M130; MBS; myosin binding subunit; myosin phosphatase targeting subunit 1; myosin phosphatase, target subunit 1; myosin phosphatase-targeting subunit 1; protein phosphatase myosin-binding subunit; protein phosphatase 1, regulatory (inhibitor) subunit 12A; MYPT1; MGC133042
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PPP1R12A-2947H Recombinant Human PPP1R12A protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PPP1R12A-2947HCL Recombinant Human PPP1R12A 293 Cell Lysate HEK293 N/A
    Human PPP1R12A-2948H Recombinant Human PPP1R12A protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse PPP1R12A-13214M Recombinant Mouse PPP1R12A Protein Mammalian Cell His
    Rat PPP1R12A-4614R Recombinant Rat PPP1R12A Protein Mammalian Cell His
    Rhesus Macaque PPP1R12A-3562R Recombinant Rhesus monkey PPP1R12A Protein, His-tagged Mammalian Cell His
    Chicken PPP1R12A-6680C Recombinant Chicken PPP1R12A Mammalian Cell His
    Zebrafish PPP1R12A-1157Z Recombinant Zebrafish PPP1R12A Mammalian Cell His

    PPP1R12A involved in several pathways and played different roles in them. We selected most pathways PPP1R12A participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Vascular smooth muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP1R12A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cGMP-PKG signaling pathway PPP3CB; ATP1B2; MAP2K2; MYLK; PPIF; GNAI2; NOS3; GUCY1B3; PPP3CA; Adcy4
    cAMP signaling pathway ATP1A2; RAP1B; PLCE1; MAP2K1; TNNI3; CNGA4; CALM2; SOX9; GRIN2D; GNAI1
    Vascular smooth muscle contraction PLA2G4D; PLA2G1B; PLA2G3; CALM3; CYP4A10; EDNRAA; PRKCB; MYH11; PRKACBA; BRAF
    Platelet activation FGG; COL24A1; Adcy4; MYL12A; TLN1; PRKG2; PLCG2; SRC; PIK3R1; APBB1IP
    Regulation of actin cytoskeleton FGF13; RAF1A; RRAS; ARPC5LA; FGF1; MYLPFB; PIK3R2; EZRB; WASF1; WASLA
    Oxytocin signaling pathway CALML3; GUCY1A3; CACNA2D1; CAMK1D; RYR3; PPP1R12A; MAPK7; RAF1; MAPK1; NPR1
    Proteoglycans in cancer FZD5; Fasl; WNT8A; PAK1; HGF; CAMK2A; MET; SLC9A1; HSPB2; WNT8B

    PPP1R12A has several biochemical functions, for example, 14-3-3 protein binding, enzyme inhibitor activity, phosphatase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP1R12A itself. We selected most functions PPP1R12A had, and list some proteins which have the same functions with PPP1R12A. You can find most of the proteins on our site.

    Function Related Protein
    14-3-3 protein binding HDAC7; IRS2; KIF13B; PPP1R12A; ARRB2; AKT1; RPTOR; HDAC7A; KCNH1; DDIT4
    enzyme inhibitor activity ATPIF1; HSPBP1; ARRB1; WDTC1; UGT1A7; TXNIP; SLN; KIAA1967; PDE6H; DGKZ
    phosphatase regulator activity PPP1R12A; SBF1; PPP1R12B; MTMR12; BMP2K
    protein binding FAM164C; PKP1; ATXN10; ERH; AP5Z1; PARVA; FOXC2; MED12; RFPL4; RAB6B
    protein kinase binding PLK1; ITGB1BP1; SPDYB; CDKN2B; DLG1L; PEBP1; B4GALT1; SLC12A4; KAT2B; RHOD
    signal transducer activity TAS2R104; IRS4; TAAR15; TMTOPS2A; TAAR6; TAS2R144; GHRHRA; OLFR476; PTH1RB; RGS6

    PPP1R12A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP1R12A here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP1R12A.

    DAPK3; DMPK; PPP1CB; MPRIP; Cdc42bpa; PTPRJ; Rock2; Cdc42bpb; Stag2; FOS; FYN

    Zhang, XM; Ma, DJ; et al. Quantitative phosphoproteomics reveals novel phosphorylation events in insulin signaling regulated by protein phosphatase 1 regulatory subunit 12A. JOURNAL OF PROTEOMICS 109:63-75(2014).
    Geetha, T; Langlais, P; et al. Protein phosphatase 1 regulatory subunit 12A and catalytic subunit delta, new members in the phosphatidylinositide 3 kinase insulin-signaling pathway. JOURNAL OF ENDOCRINOLOGY 214:437-443(2012).

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