|Official Full Name||protein phosphatase 2, regulatory subunit A, beta|
|Background||This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described.|
|Synonyms||PPP2R1B; protein phosphatase 2, regulatory subunit A, beta; protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform , protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; PP2A A beta; PP2A Abeta; PR65B; protein phosphatase 2A; regulatory subunit A; beta isoform; 2AAB_HUMAN; beta isoform of regulatory subunit A, protein phosphatase 2; PP2A subunit A isoform PR65-beta; PP2A subunit A isoform R1-beta; PP2A, subunit A, PR65 beta isoform; PP2A, subunit A, R1 beta isoform; protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform; protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform; protein phosphatase 2, structural/regulatory subunit A, beta isoform; serine/threonine protein phosphatase 2A 65 kDa regulatory subunit A, beta isoform; serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, beta isoform; PP2A, subunit A, R1-beta isoform; PP2A, subunit A, PR65-beta isoform; protein phosphatase 2, structural/regulatory subunit A, beta; PP2A-Abeta|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
PPP2R1B involved in several pathways and played different roles in them. We selected most pathways PPP2R1B participated on our site, such as mRNA surveillance pathway, Sphingolipid signaling pathway, Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP2R1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|mRNA surveillance pathway||HBS1L; EIF4A3; GSPT1L; PELO; PPP2CA; PAPOLG; PPP2R5D; PNN; GSPT1; SMG1|
|Sphingolipid signaling pathway||GNAI3; PPP2R2B; TRP53; GAB2; PLCB4; GNA12; FYN; MAPK13; S1PR4; PPP2R5A|
|Oocyte meiosis||PRKACB; PTTG2; CPEB1B; ANAPC5; CALM1A; IGF1RB; INS2; SKP1; MAD2L1; FBXW11B|
|PIK-Akt signaling pathway||ITGA4; GNG11; Fgf15; EPO; RBL2; VWF; GNG5; FGF18; EIF4E1B; IFNA5|
|AMPK signaling pathway||PIK3CD; PRKAB1; PPP2R5B; PCK1; STK11; ELAVL1; PPP2R3C; RPS6KB2; CREB3L1; PFKL|
|Adrenergic signaling in cardiomyocytes||ADCY1A; PPP2R5E; ADRa1A; PIK3R2; CACNB2; PLCB2; CACNA1SA; TNNC1; TNNT2; MAPK11|
|TGF-beta signaling pathway||BMP2; INHBA; FST; BMP2B; ID2B; BMP7; NBL1; ACVR1BA; RHOAB; ACVR2B|
|Hippo signaling pathway||BMP6; PARD6B; WNT9A; RASSF1; TCF7L2; CTNNA3; BMP8B; SCRIB; AXIN2; ACTB|
|Tight junction||SHROOM4; SHROOM2; GNAI2A; CLDN10; SHROOM1; EPB41L1; SYMPK; AKT1; CLDN2; ACTN1|
|Dopaminergic synapse||PPP2R3A; GRIN2B; CLOCK; MAPK13; KIF5B; TH; CALML3; CREB3L2; GNAI1; PLCB1|
|Long-term depression||CRH; PLA2G4A; MAP2K1; GRIA3; BRAF; NOS1; PRKCB; GRIA2; GNAQ; PLCB3|
|Chagas disease (American trypanosomiasis)||PIK3CG; TICAM1; CD3E; CD3D; CCL5; MAPK9; SMAD2; GNAO1; GNAI3; IL12B; Ccl12|
|Hepatitis C||PPP2R1A; EIF2AK3; PDPK1; CLDN20; IFNA21; RELA; TYK2; MAVS; PIK3CD; PPARA|
PPP2R1B has several biochemical functions, for example, protein binding, protein phosphatase type 2A regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP2R1B itself. We selected most functions PPP2R1B had, and list some proteins which have the same functions with PPP2R1B. You can find most of the proteins on our site.
|protein binding||CDK11B; CBX7; EP300; SPINK2; TIMM50; PARVA; ALPI; MYO7A; CRLF1; HK1|
|protein phosphatase type 2A regulator activity||PPP2R5CB; PPME1; ARPP19; PPP2R5E; PPP2R2BB; PPP2R5A; ENSAA; PPP2R4; PPP2R5D; PPP2R5EB|
PPP2R1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP2R1B here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP2R1B.
PPP2CA; STRN3; PPP2R5D; STRN; PPP2R5E