PPP2R1B Protein, protein phosphatase 2, regulatory subunit A, beta

PPP2R1B

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PPP2R1B

Official Full Name protein phosphatase 2, regulatory subunit A, beta
Background This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described.
Synonyms PPP2R1B; protein phosphatase 2, regulatory subunit A, beta; protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform , protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; PP2A A beta; PP2A Abeta; PR65B; protein phosphatase 2A; regulatory subunit A; beta isoform; 2AAB_HUMAN; beta isoform of regulatory subunit A, protein phosphatase 2; PP2A subunit A isoform PR65-beta; PP2A subunit A isoform R1-beta; PP2A, subunit A, PR65 beta isoform; PP2A, subunit A, R1 beta isoform; protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform; protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform; protein phosphatase 2, structural/regulatory subunit A, beta isoform; serine/threonine protein phosphatase 2A 65 kDa regulatory subunit A, beta isoform; serine/threonine protein phosphatase 2A, 65 kDa regulatory subunit A, beta isoform; PP2A, subunit A, R1-beta isoform; PP2A, subunit A, PR65-beta isoform; protein phosphatase 2, structural/regulatory subunit A, beta; PP2A-Abeta
    • Species :
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PPP2R1B-1915H Recombinant Human PPP2R1B, GST-tagged E.coli GST
    Human PPP2R1B-27569TH Recombinant Human PPP2R1B Wheat Germ N/A
    Human PPP2R1B-2925HCL Recombinant Human PPP2R1B 293 Cell Lysate HEK293 N/A
    Rat PPP2R1B-4633R Recombinant Rat PPP2R1B Protein Mammalian Cell His
    Zebrafish PPP2R1B-1432Z Recombinant Zebrafish PPP2R1B Mammalian Cell His

    PPP2R1B involved in several pathways and played different roles in them. We selected most pathways PPP2R1B participated on our site, such as mRNA surveillance pathway, Sphingolipid signaling pathway, Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP2R1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    mRNA surveillance pathway HBS1L; EIF4A3; GSPT1L; PELO; PPP2CA; PAPOLG; PPP2R5D; PNN; GSPT1; SMG1
    Sphingolipid signaling pathway GNAI3; PPP2R2B; TRP53; GAB2; PLCB4; GNA12; FYN; MAPK13; S1PR4; PPP2R5A
    Oocyte meiosis PRKACB; PTTG2; CPEB1B; ANAPC5; CALM1A; IGF1RB; INS2; SKP1; MAD2L1; FBXW11B
    PIK-Akt signaling pathway ITGA4; GNG11; Fgf15; EPO; RBL2; VWF; GNG5; FGF18; EIF4E1B; IFNA5
    AMPK signaling pathway PIK3CD; PRKAB1; PPP2R5B; PCK1; STK11; ELAVL1; PPP2R3C; RPS6KB2; CREB3L1; PFKL
    Adrenergic signaling in cardiomyocytes ADCY1A; PPP2R5E; ADRa1A; PIK3R2; CACNB2; PLCB2; CACNA1SA; TNNC1; TNNT2; MAPK11
    TGF-beta signaling pathway BMP2; INHBA; FST; BMP2B; ID2B; BMP7; NBL1; ACVR1BA; RHOAB; ACVR2B
    Hippo signaling pathway BMP6; PARD6B; WNT9A; RASSF1; TCF7L2; CTNNA3; BMP8B; SCRIB; AXIN2; ACTB
    Tight junction SHROOM4; SHROOM2; GNAI2A; CLDN10; SHROOM1; EPB41L1; SYMPK; AKT1; CLDN2; ACTN1
    Dopaminergic synapse PPP2R3A; GRIN2B; CLOCK; MAPK13; KIF5B; TH; CALML3; CREB3L2; GNAI1; PLCB1
    Long-term depression CRH; PLA2G4A; MAP2K1; GRIA3; BRAF; NOS1; PRKCB; GRIA2; GNAQ; PLCB3
    Chagas disease (American trypanosomiasis) PIK3CG; TICAM1; CD3E; CD3D; CCL5; MAPK9; SMAD2; GNAO1; GNAI3; IL12B; Ccl12
    Hepatitis C PPP2R1A; EIF2AK3; PDPK1; CLDN20; IFNA21; RELA; TYK2; MAVS; PIK3CD; PPARA

    PPP2R1B has several biochemical functions, for example, protein binding, protein phosphatase type 2A regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP2R1B itself. We selected most functions PPP2R1B had, and list some proteins which have the same functions with PPP2R1B. You can find most of the proteins on our site.

    Function Related Protein
    protein binding CDK11B; CBX7; EP300; SPINK2; TIMM50; PARVA; ALPI; MYO7A; CRLF1; HK1
    protein phosphatase type 2A regulator activity PPP2R5CB; PPME1; ARPP19; PPP2R5E; PPP2R2BB; PPP2R5A; ENSAA; PPP2R4; PPP2R5D; PPP2R5EB

    PPP2R1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP2R1B here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP2R1B.

    PPP2CA; STRN3; PPP2R5D; STRN; PPP2R5E

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