Recombinant Human PPP2R1B

• Cat.No.: PPP2R1B-27569TH
• Product Overview: Recombinant full length Human PPP2R1B with N-terminal proprietary tag. Predicted MW 92.18kDa.

Specification

• Species: Human
• Source: Wheat Germ
• Tag: Non
• Protein Length: 601 amino acids
• Description: This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described.
• Molecular Weight: 92.180kDa inclusive of tags
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MAGASELGTGPGAAGGDGDDSLYPIAVLIDELRNEDVQLR LNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLA LAEQLGNFTGLVGGPDFAHCLLPPLENLATVEETVVRDKA VESLRQISQEHTPVALEAYFVPLVKRLASGDWFTSRTSAC GLFSVCYPRASNAVKAEIRQQFRSLCSDDTPMVRRAAASK LGEFAKVLELDSVKSEIVPLFTSLASDEQDSVRLLAVEAC VSIAQLLSQDDLETLVMPTLRQAAEDKSWRVRYMVADRFS ELQKAMGPKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKE LGENLPIEDRETIIMNQILPYIKELVSDTNQHVKSALASV IMGLSTILGKENTIEHLLPLFLAQLKDECPDVRLNIISNL DCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMP LLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATNNLMK LVQKFGTEWAQNTIVPKVLVMANDPNYLHRMTTLFCINAL SEACGQEITTKQMLPIVLKMAGDQVANVRFNVAKSLQKIG PILDTNALQGEVKPVLQKLGQDEDMDVKYFAQEAISVLAL A
• Sequence Similarities: Belongs to the phosphatase 2A regulatory subunit A family.Contains 15 HEAT repeats.

Gene Information

• Gene Name: PPP2R1B protein phosphatase 2, regulatory subunit A, beta [ Homo sapiens ]
• Official Symbol: PPP2R1B
• Synonyms: PPP2R1B; protein phosphatase 2, regulatory subunit A, beta; protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform , protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform; serine/threonine-protein phosphatase 2A
• Gene ID: 5519
• mRNA Refseq: NM_001177562
• Protein Refseq: NP_001171033
• MIM: 603113
• Uniprot ID: P30154
• Chromosome Location: 11q23.1
• Pathway: Activated TLR4 signalling, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Beta-catenin phosphorylation cascade, organism-specific biosystem; CTLA4 inhibitory signaling, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem
• Function: protein binding