ppp2r5a
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  • Official Full Name
  • protein phosphatase 2, regulatory subunit B, alpha
  • Background
  • The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene.
  • Synonyms
  • PPP2R5A; protein phosphatase 2, regulatory subunit B, alpha; protein phosphatase 2, regulatory subunit B (B56), alpha isoform , protein phosphatase 2, regulatory subunit B, alpha isoform; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; B56A; PR61A; 2A5A_HUMAN; MGC131915; PP2A B Subunit B Alpha Isoform; PP2A B Subunit B56 Alpha Isoform; PP2A B subunit isoform B-alpha; PP2A B subunit isoform B56-alpha; PP2A B subunit isoform PR61-alpha; PP2A B subunit isoform R5-alpha; PP2A B Subunit PR61 Alpha Isoform; PP2A B Subunit R5 Alpha Isoform; PR61alpha; Protein phosphatase 2 regulatory subunit B (B56) alpha isoform; Serine/Threonine Protein Phosphatase 2A 56kDa Regulatory Subunit Alpha Isoform; OTTHUMP00000034891; PP2A, B subunit, B alpha isoform; PP2A, B subunit, R5 alpha isoform; PP2A, B subunit, B56 alpha isoform; PP2A, B subunit, PR61 alpha isoform; protein phosphatase 2, regulatory subunit B, alpha isoform; protein phosphatase 2, regulatory subunit B (B56), alpha isoform; serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform
Cat.#:PPP2R5A-1919HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP2R5A, GST-tagged
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Cat.#:PPP2R5A-31104THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PPP2R5A
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Cat.#:PPP2R5A-13261MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PPP2R5A Protein
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Cat.#:PPP2R5A-3574RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PPP2R5A Protein, His-tagged
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Cat.#:PPP2R5A-1404HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PPP2R5A cell lysate
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Involved Pathway

PPP2R5A involved in several pathways and played different roles in them. We selected most pathways PPP2R5A participated on our site, such as mRNA surveillance pathway, Sphingolipid signaling pathway, Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP2R5A were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
mRNA surveillance pathway
PPP2R3C; SMG5; PPP2R2B; BAT1; WDR82; PPP1CC; CPSF5; PPP2R5D; UPF3A; PPP2R3A
Sphingolipid signaling pathway
PLCB1; DEGS1; PPP2R5A; PLD2; MAPK10; MAPK3; PDPK1; PRKCB; LASS5; TRADD
Oocyte meiosis
SMC1B; YWHAE2; MAP2K1; PRKACG; CAMK2D; YWHAQA; MAPK12; CALM3; PPP3CCA; ADCY1B
PIK-Akt signaling pathway
PIK3R2; OSMR; SPP1; YWHAE; CREB5; HGF; TCL1B1; HSP90AA1; PPP2R1A; FGFR3
AMPK signaling pathway
PFKM; AKT1; PPP2R1A; EEF2K; PPP2R3A; HNF4A; INS2; PFKFB1; PDPK1; SCD5
Adrenergic signaling in cardiomyocytes
CREB3L2; ADRA1B; ATP2B1A; ADCY3; MYL4; PLN; ADRB2B; PPP2R5EB; CALM3A; ADRB3B
Dopaminergic synapse
GNG2; PLCB3; GNG3; GNB1; PRKCA; PPP2R2C; CREB3; PPP2CB; ARRB2; CLOCK

Protein Function

PPP2R5A has several biochemical functions, for example, kinase binding, protein binding, protein phosphatase type 2A regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP2R5A itself. We selected most functions PPP2R5A had, and list some proteins which have the same functions with PPP2R5A. You can find most of the proteins on our site.
Function
Related Protein
Function kinase binding
Related Protein TOLLIP; DLG1; CDC37; MOBKL1A; HPCA; UBQLN1; TRIP6; PFKFB1; WWC3; TRADD
Function protein binding
Related Protein ZNF460; PELO; PCSK5; RINL; IL7R; TRIM22; HSP90AA1.2; BAG3; MC3R; CLDN2
Function protein phosphatase type 2A regulator activity
Related Protein PPP2R1A; PPP2R5EB; PPP2R3A; PPP2R4; PPP2R5B; ENSAA; PPP2R1B; pab1; EIF2AK2; PPP2R2A

Interacting Protein

PPP2R5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP2R5A here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP2R5A.
PPP2CA; PPP2R1A; PPP2R1B; Ppp2r1a; Sgol2; SGOL1; CHEK2