prdx3
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  • Official Full Name
  • Peroxiredoxin 3
  • Background
  • This gene encodes a protein with antioxidant function and is localized in the mitochondrion. This gene shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for this gene.
  • Synonyms
  • PRDX3; peroxiredoxin 3; AOP1; MER5; AOP-1; SP-22; PRO1748; MGC24293; MGC104387; thioredoxin-dependent peroxide reductase, mitochondrial; HBC189; prx-III; peroxiredoxin-3; peroxiredoxin III; OTTHUMP00000020590; protein MER5 homolog; antioxidant protein 1; EC 1.11.1.15
Cat.#:PRDX3-319HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRDX3 Protein, His-tagged
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Cat.#:Prdx3-320MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Prdx3 Protein, His/GST-tagged
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Cat.#:Prdx3-321RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Prdx3 Protein, His/GST-tagged
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Cat.#:PRDX3-1025HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRDX3
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Cat.#:Prdx3-1026MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Prdx3
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Cat.#:PRDX3-371HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Peroxiredoxin 3
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Cat.#:PRDX3-822HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Peroxiredoxin 3, T7-tagged
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Cat.#:PRDX3-13324MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PRDX3 Protein
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Cat.#:Prdx3-742MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Peroxiredoxin 3
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Cat.#:PRDX3-4659RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRDX3 Protein
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Cat.#:PRDX3-3591RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PRDX3 Protein, His-tagged
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Cat.#:PRDX3-2148ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PRDX3
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Cat.#:PRDX3-2881HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRDX3 293 Cell Lysate
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Involved Pathway

PRDX3 involved in several pathways and played different roles in them. We selected most pathways PRDX3 participated on our site, such as Cellular responses to stress, Detoxification of Reactive Oxygen Species, Selenium Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRDX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cellular responses to stress
RPS19BP1; HIRA; AGO1; HSPH1; RB1CC1; HMGA1B; DNAJC7; MINK1; NUP50; CBX8
Detoxification of Reactive Oxygen Species
TXNRD2; TXN2; PRDX3; Txn1; TXN; PRDX2
Selenium Pathway
TXNRD3IT1; PRDX2; SAA2; CRP; SELT; PRDX3; SELK; ALOX5AP; DIO2; SAA2-SAA4
Validated targets of C-MYC transcriptional activation
HUWE1; IREB2; DDX18; PEG10; CDCA7; LIN28B; MINA; PDCD10; PRDX3; MYCT1

Protein Function

PRDX3 has several biochemical functions, for example, alkyl hydroperoxide reductase activity, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRDX3 itself. We selected most functions PRDX3 had, and list some proteins which have the same functions with PRDX3. You can find most of the proteins on our site.
Function
Related Protein
Function alkyl hydroperoxide reductase activity
Related Protein PRDX3; RYROXD1
Function cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Related Protein TNFAIP8; SNCA; NOL3; IGF1RA; PRDX3; SERPINB1A; BIRC3; BIRC7; C1QL4L; CD27
Function identical protein binding
Related Protein FTL; HCFC1; SMN1; NCAM1; CLDND; CORO1B; ATF3; ANXA4; STAT2; SHMT2
Function kinase binding
Related Protein PPP2R5A; SGOL1; TRADD; PARK2; TAX1BP1; JAKMIP2; PRKCD; CDC37; FAS; DLG1
Function protein C-terminus binding
Related Protein MLLT4; ERCC6; PEX16; ERCC4; SNTG1; STIP1; SIAH1; MKI67; DDX1; NCF2
Function protein binding
Related Protein IRAK1; CBX6; FERMT2; HNRNPA1; DZIP1; LYAR; PLD2; AGGF1; PPP1R11; FAM20C
Function protein kinase binding
Related Protein GPRC5B; CEP68; TRIM22; SPDYB; CDC42; TENC1; RPS19; CCNE2; CD24; KIF20A
Function thioredoxin peroxidase activity
Related Protein PRDX1; PRDX3; PRDX2; PRDX4

Interacting Protein

PRDX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRDX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRDX3.
LRRK2; GORASP2; VCAM1