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PRDX3

  • Official Full Name

    Peroxiredoxin 3

  • Overview

    This gene encodes a protein with antioxidant function and is localized in the mitochondrion. This gene shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for this gene.
  • Synonyms

    PRDX3; peroxiredoxin 3; AOP1; MER5; AOP-1; SP-22; PRO1748; MGC24293; MGC104387; thioredoxin-dependent peroxide reductase, mitochondrial; HBC189; prx-III; peroxiredoxin-3; peroxiredoxin III; OTTHUMP00000020590; protein MER5 homolog; antioxidant protein 1; EC 1.11.1.15;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • MYC
  • N/A
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRDX3-371H Recombinant Human Peroxiredoxin 3 E.coli N/A
Human PRDX3-1025H Recombinant Human PRDX3 E.coli N/A
Human PRDX3-822H Recombinant Human Peroxiredoxin 3, T7-tagged E.coli T7
Human PRDX3-2881HCL Recombinant Human PRDX3 293 Cell Lysate HEK293 N/A
Human PRDX3-319H Recombinant Human PRDX3 Protein, His-tagged E.coli His Val5~Trp233
Human PRDX3-5577H Recombinant Human PRDX3 Protein (Val5-Trp233), His tagged E.coli His Val5-Trp233
Human PRDX3-4361H Recombinant Human PRDX3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Prdx3-1026M Recombinant Mouse Prdx3 E.coli N/A
Mouse Prdx3-742M Recombinant Mouse Peroxiredoxin 3 E.coli N/A
Mouse PRDX3-13324M Recombinant Mouse PRDX3 Protein Mammalian Cell His
Mouse PRDX3-7071M Recombinant Mouse PRDX3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Prdx3-320M Recombinant Mouse Prdx3 Protein, His/GST-tagged E.coli His/GST Pro64~Gln257
Mouse Prdx3-611M Recombinant Mouse Prdx3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse PRDX3-7071M-B Recombinant Mouse PRDX3 Protein Pre-coupled Magnetic Beads HEK293
Rat PRDX3-4659R Recombinant Rat PRDX3 Protein Mammalian Cell His
Rat PRDX3-4318R Recombinant Rat PRDX3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PRDX3-4318R-B Recombinant Rat PRDX3 Protein Pre-coupled Magnetic Beads HEK293
Rat Prdx3-321R Recombinant Rat Prdx3 Protein, His/GST-tagged E.coli His/GST Pro64~Gln257
Rhesus Macaque PRDX3-3591R Recombinant Rhesus monkey PRDX3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PRDX3-3409R Recombinant Rhesus Macaque PRDX3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PRDX3-3409R-B Recombinant Rhesus Macaque PRDX3 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PRDX3-2148Z Recombinant Zebrafish PRDX3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PRDX3 Related Research Area

PRDX3 involved in several pathways and played different roles in them. We selected most pathways PRDX3 participated on our site, such as Cellular responses to stress, Detoxification of Reactive Oxygen Species, Selenium Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRDX3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cellular responses to stressRBBP7;ATG9A;PHC3;NUP35;DYNLL2B;BMI1B;RRAGA;CBX6A;HSPA12B
Detoxification of Reactive Oxygen SpeciesTXN;Txn1;TXNRD2;PRDX2;PRDX3;TXN2
Selenium PathwaySAA4;SAA2;SELT;PRDX2;SELK;ALOX5AP;SAA2-SAA4;MSRB1;PRDX3
Validated targets of C-MYC transcriptional activationPEG10;MINA;PRDX3;SERPINI1;DDX18;MTDH;MYCT1;HUWE1;CDCA7

PRDX3 has several biochemical functions, for example, alkyl hydroperoxide reductase activity, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRDX3 itself. We selected most functions PRDX3 had, and list some proteins which have the same functions with PRDX3. You can find most of the proteins on our site.

Function Related Protein
alkyl hydroperoxide reductase activityRYROXD1;PRDX3
cysteine-type endopeptidase inhibitor activity involved in apoptotic processAVP;GAS6;MT3;CD27;SNCA;RPS6KA3;PRDX3;IGF1RB;BIRC5
identical protein bindingSTAT2;NFKBIA;DCP1A;ACTN2;TRIM39;PLIN5;CEACAM5;HSD17B10;MAP3K13
kinase bindingCHIA;EMP2;TRIP6;TENC1;PPP2R5A;RPS3;BTG1;CDC6;PFKFB1
protein C-terminus bindingPEX5;BLOC1S2;DAB2;ATF4;TJP2;PDZD3;SLC9A3R2;XRCC5;PICK1
protein bindingEFNA4;GSTM5;GADD45GIP1;LETM1;FAM90A1;DUT;C18orf1;PCID2;PGLS
protein kinase bindingTP53;MAP3K1;SQSTM1;CDKN2B;TRAF2;TUBB3;RB1CC1;TEX14;PPP1R12C
thioredoxin peroxidase activityPRDX3;PRDX4;PRDX1;PRDX2

PRDX3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRDX3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRDX3.

LRRK2; GORASP2; VCAM1

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