prelp
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  • Official Full Name
  • proline/arginine-rich end leucine-rich repeat protein
  • Background
  • The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed.
  • Synonyms
  • PRELP; proline/arginine-rich end leucine-rich repeat protein; proline arginine rich end leucine rich repeat protein; prolargin; prolargin proteoglycan; SLRR2A; 55 kDa leucine rich repeat protein of articular cartilage; MST161; MSTP161; PRELP_HUMAN; Proline-arginine-rich end leucine-rich repeat protein; Proline/arginine rich end leucine rich repeat protein; OTTHUMP00000034099; 55 kDa leucine-rich repeat protein of articular cartilage
Cat.#:PRELP-2906HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRELP Protein, MYC/DDK-tagged
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Cat.#:PRELP-30073THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PRELP
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Cat.#:PRELP-371HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRELP
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Cat.#:PRELP-372HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRELP, Fc-tagged
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Cat.#:PRELP-4664RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRELP Protein
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Cat.#:PRELP-3596RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PRELP Protein, His-tagged
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Cat.#:PRELP-001HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRELP cell lysate
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Cat.#:PRELP-002HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRELP cell lysate
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Involved Pathway

PRELP involved in several pathways and played different roles in them. We selected most pathways PRELP participated on our site, such as Defective B4GALT1 causes B4GALT1-CDG (CDG-2d), Defective CHST6 causes MCDC1, Defective ST3GAL3 causes MCT12 and EIEE15, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRELP were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
PRELP; KERA; ACAN; OGN; FMOD
Defective CHST6 causes MCDC1
PRELP; OGN; FMOD; KERA; ACAN
Defective ST3GAL3 causes MCT12 and EIEE15
FMOD; KERA; ACAN; OGN; PRELP
Disease
TIRAP; CDK8; TRIM24; STRA6; NMT2; OPN1LW; PSTPIP2; RBP1; TLR10; KERA
Diseases associated with glycosaminoglycan metabolism
ACAN; PRELP; OGN; FMOD; KERA
Diseases of glycosylation
KERA; FMOD; OGN; ACAN; PRELP
Glycosaminoglycan metabolism
CSPG5B; GPC5A; UST; CHP; SLC26A2; CHST14; OGN; FMODA; Gpc2; GLB1L
Keratan sulfate biosynthesis
SLC35D2; KERA; OMD; B3GNT1; B3GNT2A; B3GNT3; FMODA; PRELP; OGN; ST3GAL3A

Protein Function

PRELP has several biochemical functions, for example, extracellular matrix structural constituent, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRELP itself. We selected most functions PRELP had, and list some proteins which have the same functions with PRELP. You can find most of the proteins on our site.
Function
Related Protein
Function extracellular matrix structural constituent
Related Protein EFEMP2; COL1A2; CHI3L1; COMP; MATN3; COL11A1B; COL3A1; COL4A3; FBLN2; LAMA1
Function heparin binding
Related Protein SERPIND1; VEGFB; COL13A1; FGF9; PGF; TGFBR3; HSD17B12; Epy; ZNF207; THBS2

Interacting Protein

PRELP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRELP here. Most of them are supplied by our site. Hope this information will be useful for your research of PRELP.
Dlg4; yjdI

PRELP Related Articles

Birke, MT; Lipo, E; et al. AAV-mediated expression of human PRELP inhibits complement activation, choroidal neovascularization and deposition of membrane attack complex in mice. GENE THERAPY 21:507-513(2014).
Rucci, N; Capulli, M; et al. Proline/arginine-rich end leucine-rich repeat protein N-terminus is a novel osteoclast antagonist that counteracts bone loss. JOURNAL OF BONE AND MINERAL RESEARCH 28:1912-1924(2013).