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PREX1

Official Full Name

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
Overview

The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs).It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.
Synonyms

PREX1; phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; KIAA1415; P REX1; ptdIns(3,4,5)-dependent Rac exchanger 1; P-REX1;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Mouse	PREX1-13334M	Recombinant Mouse PREX1 Protein	Mammalian Cell	His	Inquiry
Mouse	PREX1-7078M	Recombinant Mouse PREX1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	PREX1-7078M-B	Recombinant Mouse PREX1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein
PREX1 Related Articles
PREX1 Related Signal Pathway

PREX1 involved in several pathways and played different roles in them. We selected most pathways PREX1 participated on our site, such as Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PREX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Chemokine signaling pathway	LYN;MAP2K1;CCL4;AMCF-II;CCL5;CXCL1;FOXO3;RHOA;CCL23

PREX1 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity, phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PREX1 itself. We selected most functions PREX1 had, and list some proteins which have the same functions with PREX1. You can find most of the proteins on our site.

Function	Related Protein
Rho guanyl-nucleotide exchange factor activity	KALRNB;VAV2;ARHGEF2;ARHGEF7B;ARHGEF9;ITSN2A;QUO;ARHGEF39;PLEKHG5
guanyl-nucleotide exchange factor activity	SH2D3A;DOCK6;VAV1;RAPGEF3;DENND6A;ARHGEF7B;FGD3;RASGEF1C;GCGR
phospholipid binding	AMPH;SEC14L2;MYOF;SHC1;PACSIN1A;PSD2;BAD;APOC3;APOB

PREX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PREX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PREX1.

Abi1

Hodakoski, C; Hopkins, BD; et al. Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:155-160(2014).

Ebi, H; Costa, C; et al. PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110:21124-21129(2013).