prex1
Share
  • Official Full Name
  • phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
  • Background
  • The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs).It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.
  • Synonyms
  • PREX1; phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; KIAA1415; P REX1; ptdIns(3,4,5)-dependent Rac exchanger 1; P-REX1
Cat.#:PREX1-13334MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PREX1 Protein
+Inquiry

Involved Pathway

PREX1 involved in several pathways and played different roles in them. We selected most pathways PREX1 participated on our site, such as Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PREX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chemokine signaling pathway
Ccl12; HRAS; BCAR1; RAC2; PPBP; PIK3CB; GNG10; CXCL11; CXCL8; PF4

Protein Function

PREX1 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity, phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PREX1 itself. We selected most functions PREX1 had, and list some proteins which have the same functions with PREX1. You can find most of the proteins on our site.
Function
Related Protein
Function Rho guanyl-nucleotide exchange factor activity
Related Protein FARP1; DOCK9; ITSN2B; ARHGEF25; ARHGEF7; TRIOA; ARHGEF9B; ECT2; ARHGEF6; ARHGEF12
Function guanyl-nucleotide exchange factor activity
Related Protein RASGRP1; DIS3; TBXA2R; EIF2B5; RAPGEFL1; ITSN2A; ARHGEF11; VAV2; ANKRD27; RASGEF1BA
Function phospholipid binding
Related Protein LRBA; SYTL4; LPAR3; Defa4; PSD4; TICAM2; F10; VAMP2; NR5A2; SHC1

Interacting Protein

PREX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PREX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PREX1.
Abi1

PREX1 Related Articles

Hodakoski, C; Hopkins, BD; et al. Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:155-160(2014).
Ebi, H; Costa, C; et al. PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 110:21124-21129(2013).