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PRIM2

  • Official Full Name

    primase, DNA, polypeptide 2 (58kDa)

  • Overview

    The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the large, 58 kDa primase subunit.
  • Synonyms

    PRIM2; primase, DNA, polypeptide 2 (58kDa); PRIM2A, primase, polypeptide 2A (58kD) , primase, polypeptide 2A, 58kDa; DNA primase large subunit; DNA primase 58kDa subunit; DNA primase p58; DNA primase subunit p58; p58; Polypeptide 2A p58; PRIM2A; Primase DNA polypeptide 2 (58kDa); Primase polpeptide 2A (58kD); Primase polpeptide 2A 58kDa; dJ422B11.1.1; DNA primase 58 kDa subunit; primase polypeptide 2A, 58kDa;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRIM2-2889H Recombinant Human PRIM2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PRIM2-5440H Recombinant Human PRIM2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PRIM2-3242H Recombinant Human PRIM2 protein, His-tagged E.coli His 1-158 aa
Mouse PRIM2-13346M Recombinant Mouse PRIM2 Protein Mammalian Cell His
Mouse PRIM2-7083M-B Recombinant Mouse PRIM2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Prim2-5109M Recombinant Mouse Prim2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PRIM2-7083M Recombinant Mouse PRIM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PRIM2-3600R Recombinant Rhesus monkey PRIM2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PRIM2-3418R Recombinant Rhesus Macaque PRIM2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PRIM2-3418R-B Recombinant Rhesus Macaque PRIM2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PRIM2-12797Z Recombinant Zebrafish PRIM2 Mammalian Cell His
Chicken PRIM2-2097C Recombinant Chicken PRIM2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PRIM2 Related Articles

PRIM2 involved in several pathways and played different roles in them. We selected most pathways PRIM2 participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRIM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismPOLR2C;POLR2K;PDE5AB;PDE7B;PRPS2;PRPS1;PAPSS2B;NME1-NME2;POLR1D
Pyrimidine metabolismPOLE4;NT5C2A;NT5E;CMPK2;DUT;NT5C2B;AK9;RRM2B;NT5C1BA
Metabolic pathwaysB3GALT6;UMPS;ALG9;ACSL4A;GLCEB;HSD3B6;KCNG4;AK7B;OXSR1
DNA replicationRNASEH2B;POLE2;POLE;RFC2;RNASEH2C;LIG1;CDT1;RNASEH2A;RFC5

PRIM2 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, ATP:coenzyme F420 adenylyltransferase activity, CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRIM2 itself. We selected most functions PRIM2 had, and list some proteins which have the same functions with PRIM2. You can find most of the proteins on our site.

Function Related Protein
4 iron, 4 sulfur cluster bindingMOCS1;MUTYH;ISCUB;POLD1;ISCA2;ISCU;NDUFS8B;ACO2;DDX11
ATP:coenzyme F420 adenylyltransferase activityUAP1L1;CCDC111;CTU1;PRIM2
CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activityCTU1;UAP1L1;CCDC111;PRIM2
DNA bindingHNF1BA;PCXA;ZSCAN4C;CRY2;TCEB3;DRGX;HIST1H2B8;ZBED5;POLR2I
DNA primase activityCCDC111;PRIM1;UAP1L1;PRIMPOL;PRIM2;CTU1
DNA-directed RNA polymerase activityPRIM2;POLR2J;POLR3K;POLR2B;POLRMT;POLR3B;POLR2GL;POLR2I;POLR3H
DNA/RNA helicase activityUAP1L1;CCDC111;PRIM2;CTU1
RNA guanylyltransferase activityRNGTT;PRIM2;CCDC111;UAP1L1;CTU1
RNA helicase activityDHX16;DDX24;DDX6;DDX10;RAD54B;DDX17;SKIV2L2;CTU1;FAM120B
UDP-N-acetylgalactosamine diphosphorylase activityCTU1;UAP1L1;PRIM2;CCDC111
iron-sulfur cluster bindingAOX4;AOX3L1;NDUFS1;NFS1;EXO5;GLRX3;CMAH;AOX3;FDX1B
mannose-phosphate guanylyltransferase activityCCDC111;UAP1L1;CTU1;PRIM2
metal ion bindingPDLIM5A;NDUFV2;ZFP91;CREB5;FGD1;SUMF1;CNOT7;PPM1AA;CYP2AA1
nucleotidyltransferase activityMOCS3;TERT;CMASB;GMPPA;GKUP;POLN;GDPGP1;GMPPAB;POLR2B
phospholactate guanylyltransferase activityCTU1;CCDC111;UAP1L1;PRIM2
sulfate adenylyltransferase activityCCDC111;PRIM2;UAP1L1;CTU1
tRNA guanylyltransferase activityTHG1L;PRIM2;UAP1L1;CTU1;CCDC111;USP14
telomerase activityCCDC111;TERT;UAP1L1;DKC1;PRIM2;CTU1;PTGES3
transferase activityDNMT4;ZDHHC22;CMPK;UBIAD1;MAP2K4A;TGFBR1B;NME2A;ACAA1A;B4GALNT4

PRIM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRIM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRIM2.

Pola2; Iqcb1; Prim1; Pola1

Liu, D; Zhang, XX; et al. Sine oculis homeobox homolog 1 promotes DNA replication and cell proliferation in cervical cancer. INTERNATIONAL JOURNAL OF ONCOLOGY 45:1232-1240(2014).
Chung, J; Tsai, S; et al. Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells. EPIGENETICS 7:429-431(2012).
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