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Official Full Name primase, DNA, polypeptide 2 (58kDa)
Background The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the large, 58 kDa primase subunit.
Synonyms PRIM2; primase, DNA, polypeptide 2 (58kDa); PRIM2A, primase, polypeptide 2A (58kD) , primase, polypeptide 2A, 58kDa; DNA primase large subunit; DNA primase 58kDa subunit; DNA primase p58; DNA primase subunit p58; p58; Polypeptide 2A p58; PRIM2A; Primase DNA polypeptide 2 (58kDa); Primase polpeptide 2A (58kD); Primase polpeptide 2A 58kDa; dJ422B11.1.1; DNA primase 58 kDa subunit; primase polypeptide 2A, 58kDa
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • Myc/DDK
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Prim2-5109M Recombinant Mouse Prim2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human PRIM2-5440H Recombinant Human PRIM2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human PRIM2-2889H Recombinant Human PRIM2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Mouse PRIM2-13346M Recombinant Mouse PRIM2 Protein Mammalian Cell His
    Rhesus Macaque PRIM2-3600R Recombinant Rhesus monkey PRIM2 Protein, His-tagged Mammalian Cell His
    Chicken PRIM2-2097C Recombinant Chicken PRIM2 Mammalian Cell His
    Zebrafish PRIM2-12797Z Recombinant Zebrafish PRIM2 Mammalian Cell His

    PRIM2 involved in several pathways and played different roles in them. We selected most pathways PRIM2 participated on our site, such as Purine metabolism, Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRIM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Purine metabolism POLR2H; POLR3B; ADKB; NUDT9; PRIM1; PNP6; ENPP1; POLR3A; POLR2J3; ENTPD4
    Pyrimidine metabolism POLE2; POLR3A; PNPT1; NT5E; POLR2A; RRM2B; CTPS2; TYMP; POLR2J; NUDT2
    Metabolic pathways TRIT1; ASAH1; PEMT; CYP19A1B; ETNK2; GOT2A; ALG8; POLR2K; CMPK1; NME2B.1
    DNA replication RFC4; rnhA; FEN1; MCM6L; SSBP1; POLD2; MCM6; RFC5; GINS1; RFC3

    PRIM2 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, ATP:coenzyme F420 adenylyltransferase activity, CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRIM2 itself. We selected most functions PRIM2 had, and list some proteins which have the same functions with PRIM2. You can find most of the proteins on our site.

    Function Related Protein
    4 iron, 4 sulfur cluster binding NDUFS7; NFU1; ETFDH; PPAT; ISCU; NUBP2; NTHL1; IREB2; REV3L; ISCA1
    ATP:coenzyme F420 adenylyltransferase activity CCDC111; CTU1; PRIM2; UAP1L1
    CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity PRIM2; CTU1; CCDC111; UAP1L1
    DNA binding SNAPC3; PHOX2BB; SS18L1; HELT; IRF7; ZNF577; PCBP3; NKX2; SOX2; LIN28B
    DNA primase activity CTU1; UAP1L1; PRIM2; PRIMPOL; CCDC111; PRIM1
    DNA-directed RNA polymerase activity POLR3B; RPAP1; POLR3G; CCDC111; POLR2GL; POLR3A; POLR2I; POLR2M; MED20; POLR2A
    DNA/RNA helicase activity UAP1L1; PRIM2; CCDC111; CTU1
    RNA guanylyltransferase activity RNGTT; PRIM2; CCDC111; UAP1L1; CTU1
    RNA helicase activity FAM120B; DHX16; CCDC111; DDX5; DDX6; DDX10; DHX15; CTU1; PRIM2; DDX17
    UDP-N-acetylgalactosamine diphosphorylase activity CTU1; UAP1L1; CCDC111; PRIM2
    iron-sulfur cluster binding REV3L; DPYDA.1; GLRX3; DPYDB; ISCUB; RSAD1; RPS3; NFS1; NDUFS1; PROZA
    mannose-phosphate guanylyltransferase activity PRIM2; UAP1L1; CCDC111; CTU1
    metal ion binding ZNF502; SETDB1B; SP3A; TIMP4; PVALB7; AGFG1A; ESR2B; ETFDH; TYRP1B; MUTYH
    nucleotidyltransferase activity POLN; UAP1L1; GMPPAA; GMPPAB; POLR3B; PRIM2; TERT; TAMM41; PAPSS2; PAPSS1
    phospholactate guanylyltransferase activity CCDC111; UAP1L1; PRIM2; CTU1
    sulfate adenylyltransferase activity UAP1L1; CCDC111; PRIM2; CTU1
    tRNA guanylyltransferase activity UAP1L1; THG1L; CTU1; USP14; PRIM2; CCDC111
    telomerase activity CTU1; DKC1; PTGES3; UAP1L1; CCDC111; TERT; PRIM2
    transferase activity PRKAR1AA; PTK2AA; MIBP; TPMT.1; CKMT2B; PIP5K1AA; SPS2; PHKG1A; MGAT3A; BST1

    PRIM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRIM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRIM2.

    Pola2; Iqcb1; Prim1; Pola1

    Liu, D; Zhang, XX; et al. Sine oculis homeobox homolog 1 promotes DNA replication and cell proliferation in cervical cancer. INTERNATIONAL JOURNAL OF ONCOLOGY 45:1232-1240(2014).
    Chung, J; Tsai, S; et al. Lack of genomic imprinting of DNA primase, polypeptide 2 (PRIM2) in human term placenta and white blood cells. EPIGENETICS 7:429-431(2012).

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