prkag1
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  • Official Full Name
  • protein kinase, AMP-activated, gamma 1 non-catalytic subunit
  • Background
  • The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
  • Synonyms
  • PRKAG1; protein kinase, AMP-activated, gamma 1 non-catalytic subunit; 5-AMP-activated protein kinase subunit gamma-1; AMPK gamma1; AMPK gamma-1 chain; 5-AMP-activated protein kinase, gamma-1 subunit; AMPKG; MGC8666
Cat.#:PRKAG1-2334HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAG1, His-tagged
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Cat.#:PRKAG1-31763THTag:His
Source (Host):Species:Human
Product nameRecombinant Human Human Human PRKAA1, His-tagged
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Cat.#:PRKAG1-365HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAG1 protein, His/MBP-tagged
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Cat.#:PRKAG1-366HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAG1 protein, His/MBP-tagged
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Cat.#:PRKAG1-367HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKAG1 protein, His/MBP-tagged
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Cat.#:PRKAG1-13354MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PRKAG1 Protein
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Cat.#:PRKAG1-4673RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRKAG1 Protein
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Cat.#:PRKAG1-3603RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PRKAG1 Protein, His-tagged
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Cat.#:PRKAG1-3285CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PRKAG1
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Cat.#:PRKAG1-12377ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PRKAG1
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Cat.#:PRKAG1-2865HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PRKAG1 293 Cell Lysate
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Cat.#:PRKAG1-2866HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PRKAG1 293 Cell Lysate
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Involved Pathway

PRKAG1 involved in several pathways and played different roles in them. We selected most pathways PRKAG1 participated on our site, such as FoxO signaling pathway, AMPK signaling pathway, Circadian rhythm, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKAG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
MAPK9; PRKAG3; ATM; RBL2; PLK2B; NLK; GADD45AA; MAPK14A; HOMER1B; MDM2
AMPK signaling pathway
IRS1; RAB8A; PPARG; PFKFB4; PFKFB3; CREB3L2; RHEB; AKT1; MTOR; EIF4EBP1
Circadian rhythm
SKP1; FBXW11; PRKAG3; BTRC; PER2; RBX1; CUL1; RORC; ARNTL; BHLHE40
Insulin signaling pathway
TRIP10; PDE3B; SOCS1; HK3; SOS1; INS2; CBLB; SOCS1A; PHKG1; INPP5K
Adipocytokine signaling pathway
PCK1; MAPK10; PPARAB; PPARGC1A; G6PC3; PRKAA1; IRS4; CAMKK1; POMC; SLC2A1
Oxytocin signaling pathway
CAMK4; CALML3; CALML5; PIK3CD; PRKCG; CACNG8; PRKAA1; PPP1CC; PRKACG; PLA2G4D
Glucagon signaling pathway
ITPR1; CREB5; PPP3R1; PPP3CC; CAMK2A; CAMK2D; PHKA2; CPT1C; AKT1; PHKA1
Insulin resistance
IKBKB; SLC27A3; INS; PRKCZ; PIK3CB; NFKBIA; PPARAB; MTOR; PRKCE; PIK3R2
Non-alcoholic fatty liver disease (NAFLD)
LEPR; INS2; NDUFC2; NFKB1; TGFB1; PRKAA1; NDUFB9; LEP; PRKAG1; NDUFS4
Hypertrophic cardiomyopathy (HCM)
TPM4; PRKAA2; TGFB2; ITGA2; MYBPC3; SLC8A1; CACNG4; PRKAB2; SGCG; CACNB1

Protein Function

PRKAG1 has several biochemical functions, for example, ADP binding, AMP binding, contributes_to AMP-activated protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKAG1 itself. We selected most functions PRKAG1 had, and list some proteins which have the same functions with PRKAG1. You can find most of the proteins on our site.
Function
Related Protein
Function ADP binding
Related Protein ERN1; MYH10; ME1; PRPS2; P2RY1; MYO6; GLUD1; MYO7A; GCLC; ABCG1
Function AMP binding
Related Protein PRPS1; APRT; ACSS2; PRKAG1; CYB5R3; PYGM; PRPS2; FBP1; PRKAG2; ACSS1
Function contributes_to AMP-activated protein kinase activity
Related Protein PRKAG1; PRKAB2
Function ATP binding
Related Protein MYO7AA; SLC14A2; PKM2; PHKG1A; TTL; GTF2F2B; PRPF4BB; CHST13; ADCY9; STK17A
Function cAMP-dependent protein kinase activity
Related Protein PRKACB; PRKACG; PRKAG1; PRKX; PRKACA; PRKAA1; AKAP13
Function cAMP-dependent protein kinase regulator activity
Related Protein PRKAR1AA; PRKAR1AB; CXCL10; PRKAR1A; PRKAR2AB; PRKAR2AA; PRKAR1B; PRKAR2B; PRKAG1; PRKAR2A
Function protein binding
Related Protein HSP90AB1; UBE2F; PLLP; KRTAP2-3; SNX7; NPHP3; CIAO1; PRSS3; AEN; EIF4G1
Function protein kinase activity
Related Protein NEK2; CAMKV; ANKK1; PRKAG1; MAP4K6; PLK1; ZNF143B; PTK2AA; HIPK3; VSIG8B
Function protein kinase binding
Related Protein MAP3K5; PRKAB1; MVP; TOM1L1; AKAP7; SPAG16; LLGL1; STXBP1; GHR; MAP3K13

Interacting Protein

PRKAG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKAG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKAG1.
PRKAA1; PRKAB2; PRKAB1

PRKAG1 Related Articles

Lindholm-Perry, AK; Kuehn, LA; et al. DNA polymorphisms and transcript abundance of PRKAG2 and phosphorylated AMP-activated protein kinase in the rumen are associated with gain and feed intake in beef steers. ANIMAL GENETICS 45:461-472(2014).
Zambonelli, P; Davoli, R; et al. SNPs detection in DHPS-WDR83 overlapping genes mapping on porcine chromosome 2 in a QTL region for meat pH. BMC GENETICS 14:-(2013).