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PRKAG1

  • Official Full Name

    protein kinase, AMP-activated, gamma 1 non-catalytic subunit

  • Overview

    The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
  • Synonyms

    PRKAG1; protein kinase, AMP-activated, gamma 1 non-catalytic subunit; 5-AMP-activated protein kinase subunit gamma-1; AMPK gamma1; AMPK gamma-1 chain; 5-AMP-activated protein kinase, gamma-1 subunit; AMPKG; MGC8666;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PRKAG1-2334H Recombinant Human PRKAG1, His-tagged E.coli His 354aa
Human PRKAG1-366H Recombinant Human PRKAG1 protein, His/MBP-tagged E.coli His/MBP 118-206 aa
Human PRKAG1-365H Recombinant Human PRKAG1 protein, His/MBP-tagged E.coli His/MBP 240-318 aa
Human PRKAG1-367H Recombinant Human PRKAG1 protein, His/MBP-tagged E.coli His/MBP 5-82 aa
Human PRKAG1-31763TH Recombinant Human Human Human PRKAA1, His-tagged His
Human PRKAG1-2865HCL Recombinant Human PRKAG1 293 Cell Lysate HEK293 N/A
Human PRKAG1-2866HCL Recombinant Human PRKAG1 293 Cell Lysate HEK293 N/A
Human PRKAG1-5987H Recombinant Human PRKAG1 Protein (Arg70-Leu300), N-His tagged E.coli N-His Arg70-Leu300
Human PRKAG1-2793H Recombinant Human PRKAG1 protein, His-tagged E.coli His 164-321 aa
Mouse PRKAG1-13354M Recombinant Mouse PRKAG1 Protein Mammalian Cell His
Mouse Prkag1-5113M Recombinant Mouse Prkag1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Prkag1-4349M Recombinant Mouse Prkag1 protein, His-tagged E.coli His 1-330aa
Mouse PRKAG1-7088M Recombinant Mouse PRKAG1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PRKAG1-7088M-B Recombinant Mouse PRKAG1 Protein Pre-coupled Magnetic Beads HEK293
Rat PRKAG1-4673R Recombinant Rat PRKAG1 Protein Mammalian Cell His
Rat PRKAG1-4332R Recombinant Rat PRKAG1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PRKAG1-4332R-B Recombinant Rat PRKAG1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PRKAG1-3603R Recombinant Rhesus monkey PRKAG1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PRKAG1-3421R Recombinant Rhesus Macaque PRKAG1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PRKAG1-3421R-B Recombinant Rhesus Macaque PRKAG1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PRKAG1-12377Z Recombinant Zebrafish PRKAG1 Mammalian Cell His
Chicken PRKAG1-3285C Recombinant Chicken PRKAG1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PRKAG1 Related Articles
  • PRKAG1 Related Research Area

PRKAG1 involved in several pathways and played different roles in them. We selected most pathways PRKAG1 participated on our site, such as FoxO signaling pathway, AMPK signaling pathway, Circadian rhythm, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKAG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
FoxO signaling pathwayPRKAB1A;SGK2A;PRKAB1B;NLK2;STK11;RAF1;G6PCA.2;PTENB;CCNB2
AMPK signaling pathwayRAB10;RHEB;CPT1C;AKT2;TSC1;PPARG;IRS4;IGF1R;AKT3
Circadian rhythmSKP1;CLOCK;ARNTL;RORB;PER2;BHLHE40;PRKAA1;PER1;CSNK1E
Insulin signaling pathwayRAPGEF1B;MAPK9;PHKG2;TSC2;PRKACAB;HKDC1;TSC1;SOCS2;PPP1R3CB
Adipocytokine signaling pathwayAKT3A;CPT1C;AKT1;IRS4;NFKB1;ADIPOR1;CAMKK2;G6PC2;TRADD
Oxytocin signaling pathwayCACNB1;MYLK2;GNAI1;GNAO1;CALM2;NPR1;CACNG8;PLCB1;CAMK2D
Insulin resistancePIK3R5;PPARA;SLC27A5;SLC2A1A;CREB3L3A;PRKAA2;AKT2;PTPN11A;IKBKB
Non-alcoholic fatty liver disease (NAFLD)BAX;PIK3CA;NDUFB8;UQCR10;DDIT3;NDUFA11;SDHB;RAC1;XBP1
Hypertrophic cardiomyopathy (HCM)ITGA10;TPM4;CACNA2D2;PRKAG3;TPM1;TNNI3;TGFB3;DES;CACNG1

PRKAG1 has several biochemical functions, for example, ADP binding, AMP binding, contributes_to AMP-activated protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKAG1 itself. We selected most functions PRKAG1 had, and list some proteins which have the same functions with PRKAG1. You can find most of the proteins on our site.

Function Related Protein
ADP bindingMYO3A;ACTA1;PRPS2;MYO18A;MIEF1;CHORDC1;PRPS1;GLUD2;HSP104
AMP bindingPYGL;PRKAG1;PYGM;APRT;PRPS2;CYB5R3;FBP1;ACSS1;PRKAG2
contributes_to AMP-activated protein kinase activityPRKAB2;PRKAG1
ATP bindingNLRP10;UBE2IA;NADK;ERBB4A;FLT4;RPS6KA3;TNIKB;HSP90AA1;GTF2F2B
cAMP-dependent protein kinase activityPRKAA1;AKAP13;PRKACG;PRKAG1;PRKACB;PRKX;PRKACA
cAMP-dependent protein kinase regulator activityPRKAR1B;PRKAR2A;PRKAR1AA;PRKAG2;PRKAR1AB;PRKAR2B;PRKAR2AA;PRKAG1;PRKAR1A
protein bindingMSN;FABP5;MEPE;TMEM79;RAB7;RUNX1T1;ATG12;CHD1;TEX19.1
protein kinase activityMAPK12B;RPS6KA3A;LIMK1A;ANKK1;DYRK1AA;PAK4;GRK7A;PRKG2;CDK1
protein kinase bindingCD24;GYS1;PIWIL1;CCNA2;ILK;JAK2;GATA4;SKAP1;XBP1

PRKAG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKAG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKAG1.

PRKAA1; PRKAB2; PRKAB1

Lindholm-Perry, AK; Kuehn, LA; et al. DNA polymorphisms and transcript abundance of PRKAG2 and phosphorylated AMP-activated protein kinase in the rumen are associated with gain and feed intake in beef steers. ANIMAL GENETICS 45:461-472(2014).
Zambonelli, P; Davoli, R; et al. SNPs detection in DHPS-WDR83 overlapping genes mapping on porcine chromosome 2 in a QTL region for meat pH. BMC GENETICS 14:-(2013).
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