prkch
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  • Official Full Name
  • protein kinase C, eta
  • Background
  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene.
  • Synonyms
  • PRKCH; protein kinase C, eta; protein kinase C eta type; PKC-L; nPKC-eta; protein kinase C-eta; MGC93383
Cat.#:PRKCH-403HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Protein Kinase C, Eta, GST-tagged, Active
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Cat.#:PRKCH-18HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKCH protein, His-tagged
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Cat.#:PRKCH-19HTag:GST/His
Source (Host):Baculovirus infected Sf9 cellsSpecies:Human
Product nameRecombinant Human PRKCH protein, GST/His-tagged
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Cat.#:PRKCH-28938THTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKCH
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Cat.#:PRKCH-71HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human PRKCH protein, Flag-tagged, Biotinylated
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Cat.#:PRKCH-8457HTag:
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PRKCH
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Cat.#:PRKCH-13367MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PRKCH Protein
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Cat.#:PRKCH-4681RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRKCH Protein
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Cat.#:PRKCH-2855HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKCH 293 Cell Lysate
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Involved Pathway

PRKCH involved in several pathways and played different roles in them. We selected most pathways PRKCH participated on our site, such as Vascular smooth muscle contraction, Tight junction, Inflammatory mediator regulation of TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKCH were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Vascular smooth muscle contraction
MLCK2; PPP1CAB; ADORA2AB; KCNMA1A; PRKCQ; MYLK; AVPR1B; PLA2G2F; CYP4A12A; PRKACBB
Tight junction
GNAI3; RAB13; CLDNF; MYL12.1; MYH3; SMYHC1; ACTB2; VMHC; CLDN7A; CLDN23
Inflammatory mediator regulation of TRP channels
P2RY2; PLCB1; CYP2C39; MAPK10; PIK3CB; CYP2C37; PLCB4; MAP2K3; PIK3CG; CAMK2D

Protein Function

PRKCH has several biochemical functions, for example, ATP binding, Ral GTPase binding, calcium-independent protein kinase C activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKCH itself. We selected most functions PRKCH had, and list some proteins which have the same functions with PRKCH. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein Aatk; RPS6KA3; EPB42; PRKD2; VPRBP; GUCY2C; HSPA4B; TNIKB; TTLL13; LATS2
Function Ral GTPase binding
Related Protein LSM2; PRKCH; RNF41; USP33; RAB34; EXOC4; MYO1C; FLNA; EXOC8; PIH1D2
Function calcium-independent protein kinase C activity
Related Protein PRKCH; PRKCD; PRKCE
Function enzyme binding
Related Protein TUT1; PRKCE; HIST1H2AM; SUPT5H; HSPA1B; HOXA9; AXIN1; YWHAE; SLC12A3; HYAL2
Function metal ion binding
Related Protein CYP2P7; IDI2; RAF1; ATP2A2A; APOA1BP; CYP2K19; ZMYM2; NME4; GMEB2; ITGA2B
Function protein kinase C activity
Related Protein PRKCA; PKN2; PRKCE; PRKCB; PRKCG; PRKCH; PRKCDA; PRKCI; PRKCBA; PKN3

Interacting Protein

PRKCH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKCH here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKCH.
ndb25_parsc; HSP90AB1; glpD; ZBTB8OS