| Official Full Name | protein kinase C, eta |
| Background | Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. |
| Synonyms | PRKCH; protein kinase C, eta; protein kinase C eta type; PKC-L; nPKC-eta; protein kinase C-eta; MGC93383 |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
PRKCH involved in several pathways and played different roles in them. We selected most pathways PRKCH participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKCH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Vascular smooth muscle contraction | ROCK1; PLA2G4C; PPP1CAB; ADCY1B; PLA2G6; PRKCB; RAF1B; PRKACBB; PRKACG; ACTA2 |
| Tight junction | CLDN15A; PPP2R2BB; CLDN5; MYL9A; CRB3; HRASB; CLDN20; MYH11A; HCLS1; MPP5 |
| Inflammatory mediator regulation of TRP channels | CYP2J6; P2RY2; PIK3CG; PRKCG; PRKCD; NTRK1; PRKCQ; SRC; KLK1B4; CALML3 |
PRKCH has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKCH itself. We selected most functions PRKCH had, and list some proteins which have the same functions with PRKCH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CAMK1D; TARS; RAD17; CDK4; NUAK2; MASTL; SUPV3L1; STK3; SLC22A5; HSPA12A |
| Ral GTPase binding | EXOC8; RNF41; FLNA; RAB34; MYO1C; LSM2; PIH1D2; PRKCH; RALBP1; USP33 |
| calcium-independent protein kinase C activity | PRKCE; PRKCD; PRKCH |
| enzyme binding | SLC27A2; YWHAE; PEX5; MAPK14; TSPAN17; NOXA1; EGLN1; CTNNB1; BRCA1; PHKG2 |
| metal ion binding | CRYAA; NRXN1; GFI1AB; LIMCH1B; PRKD3; TATDN1; PHOSPHO2; NT5C2L1; ADARB2; KCNIP1B |
| protein kinase C activity | PKN1; PRKD1; PRKD2; PRKCE; PRKCB; PRKCBB; PRKCD; PRKCI; PRKCZ; PKN2 |
PRKCH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKCH here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKCH.
ndb25_parsc; HSP90AB1; glpD; ZBTB8OS
