prkg1
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  • Official Full Name
  • protein kinase, cGMP-dependent, type I
  • Background
  • Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.
  • Synonyms
  • PRKG1; protein kinase, cGMP-dependent, type I; PRKG1B, PRKGR1B; cGMP-dependent protein kinase 1; PGK; PKG; protein kinase, cGMP-dependent, regulatory, type I, beta; 1; cGK; cGK1; cGKI; cGK 1; PRKG1B; PRKGR1B; cGKI-BETA; cGKI-alpha; FLJ36117; MGC71944; DKF
Cat.#:PRKG1-26451THTag:His
Source (Host):Species:Human
Product nameRecombinant Human PRKG1, His-tagged
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Cat.#:PRKG1-26452THTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PRKG1
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Cat.#:PRKG1-413HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PRKG1, GST-tagged, Active
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Cat.#:PRKG1-563HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PRKG1, His-tagged
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Cat.#:PRKG1-564HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PRKG1, His-tagged
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Cat.#:PRKG1-604HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Protein Kinase, cGMP-dependent, Type I
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Cat.#:PRKG1-13376MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PRKG1 Protein
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Cat.#:PRKG1-2850HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PRKG1 293 Cell Lysate
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Involved Pathway

PRKG1 involved in several pathways and played different roles in them. We selected most pathways PRKG1 participated on our site, such as cGMP-PKG signaling pathway, Vascular smooth muscle contraction, Gap junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
cGMP-PKG signaling pathway
ATP1A3; ROCK2; ATP2A1; GTF2I; IRS2; PDE3B; VDAC1; LOC100328615; GTF2IRD1; SLC8A2
Vascular smooth muscle contraction
CALD1; PLA2G2E; CYP4A10; CALM1B; GNA11B; GNA12; ROCK2; KCNMB4; CALML5; ARHGEF12
Gap junction
MAP2K2A; PDGFB; EGFRA; TUBA3A; PRKACA; KRAS; TJP1; GRM1; PDGFD; GNA11A
Platelet activation
PIK3CD; PLA2G4D; FGA; PLCB4; PIK3CB; ITPR1; Adcy4; MYL12B; APBB1IP; PRKACG
Circadian entrainment
KCNJ6; PLCB3; GNAQ; GNAI3; GNB2; MAPK3; CALML3; ITPR3; PLCB4; CAMK2A
Long-term depression
GNA11; NRAS; GUCY1B3; ITPR1; HRAS; PLCB2; PLCB4; GUCY1A3; PRKG2; ITPR3
Olfactory transduction
OR52J3; OR2L5; GNAL; OR2H1; OR10A5; GNG7; OR8B8; OR2A42; OR56A1; RGS2
Regulation of lipolysis in adipocytes
TSHB; PLIN1; PDE3B; INSR; FABP4; AKT2; LOC100328615; PIK3R3; PIK3R5; PIK3CA
Salivary secretion
CALM4; CST5; CST1; STATH; CST3; ATP2B1; MUC7; PLCB2; PRB1; CALM2

Protein Function

PRKG1 has several biochemical functions, for example, ATP binding, cGMP binding, cGMP-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKG1 itself. We selected most functions PRKG1 had, and list some proteins which have the same functions with PRKG1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein SPATA5L1; TOP2A; AACS; CAMK1DA; CKMT2B; TLK1B; PI4K2B; OASL; ABCG3; PSTK
Function cGMP binding
Related Protein PDE6G; PDE6H; PRKG1A; CNGA5; CNGA2; CNGA1; PRKG2; PDE11A; CNGA4; PDE2A
Function cGMP-dependent protein kinase activity
Related Protein PRKG1; PRKG1A; PRKG2
Function calcium channel regulator activity
Related Protein GNB2; STIM1A; SGK3; SGK2B; NRXN3; TSPAN13A; SRI; GRM2; STIM1; GRM3
Function protein binding
Related Protein CHMP4A; EMG1; C19orf44; GP9; SIKE1; POLR1B; E2F3; RPS6KA5; UBAC1; METTL15

Interacting Protein

PRKG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKG1.
ZNF646; LMO2; FAM124A; BMPR2; Gkap1; 3',5'-cyclic gmp; SMAD4; 2_aha_camp; 8-aha-camp; 8-aha-omethyladenosine

PRKG1 Related Articles

Zhang, L; Lukowski, R; et al. Thrombocytosis as a Response to High Interleukin-6 Levels in cGMP-Dependent Protein Kinase I Mutant Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 33:1820-1828(2013).
Zhang, FX; Liu, XJ; et al. Inhibition of Inflammatory Pain by Activating B-Type Natriuretic Peptide Signal Pathway in Nociceptive Sensory Neurons. JOURNAL OF NEUROSCIENCE 30:10927-10938(2010).