prmt6
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  • Official Full Name
  • protein arginine methyltransferase 6
  • Background
  • The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity.
  • Synonyms
  • PRMT6; protein arginine methyltransferase 6; HMT1 hnRNP methyltransferase like 6 (S. cerevisiae) , HRMT1L6; protein arginine N-methyltransferase 6; FLJ10559; HMT1 hnRNP methyltransferase-like 6; histone-arginine N-methyltransferase PRMT6; heterogeneous nu
Cat.#:PRMT6-3002HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRMT6 Protein, MYC/DDK-tagged
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Cat.#:PRMT6-5044HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human PRMT6 Protein, GST-tagged
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Cat.#:PRMT6-453HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Protein Arginine Methyltransferase 6
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Cat.#:PRMT6-653HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human Protein Arginine Methyltransferase 6, Flag-tagged
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Cat.#:PRMT6-179HTag:GST
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human PRMT6 Protein, GST-tagged
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Cat.#:PRMT6-1970HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRMT6, GST-tagged
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Cat.#:PRMT6-318HTag:His/Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRMT6 Protein, His & FLAG-tagged
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Cat.#:PRMT6-13420MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PRMT6 Protein
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Cat.#:PRMT6-3615RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PRMT6 Protein, His-tagged
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Cat.#:PRMT6-7567ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PRMT6
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Cat.#:PRMT6-2458HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human PRMT6 cell lysate
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Cat.#:Kit-1860Tag:
Source (Host):Species:
Product namePRMT6 (HRMT1L6) Chemiluminescent Assay Kit
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Cat.#:Kit-1861Tag:
Source (Host):Species:
Product namePRMT6 (HRMT1L6) Homogeneous Assay Kit
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Involved Pathway

PRMT6 involved in several pathways and played different roles in them. We selected most pathways PRMT6 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, RMTs methylate histone arginines, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRMT6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chromatin modifying enzymes
ARID5B; DPY30; KAT7; ATXN7L3; MSL2B; RBBP7; PADI1; SMARCA2; SMARCC1B; USP22
Chromatin organization
C3orf75; SUDS3; MSL1A; ASH2L; ENY2; BRD1; MORF4L2; PRMT5; KANSL3; BRPF1
RMTs methylate histone arginines
SMARCB1A; SMARCC2; SMARCA4; SMARCD1; SMARCC1B; SMARCA2; SMARCE1; PRMT6; WDR77; PBRM1

Protein Function

PRMT6 has several biochemical functions, for example, chromatin binding, histone binding, histone methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRMT6 itself. We selected most functions PRMT6 had, and list some proteins which have the same functions with PRMT6. You can find most of the proteins on our site.
Function
Related Protein
Function chromatin binding
Related Protein CIC; SHMT2; CREB3L1; CBFA2T3; RERE; PRKAA1; MEN1; CEBPB; POLE; PAF1
Function histone binding
Related Protein SMARCA4A; L3MBTL1; PIH1D1; RCC1; MCM2; ELP2; HINFP; TONSL; NCL; ATAD2
Function histone methyltransferase activity
Related Protein PRDM13; CARM1; PRMT2; EED; SUZ12; SUV39H1; PRMT6; PRMT1; EZH2
Function histone methyltransferase activity (H2A-R3 specific)
Related Protein PRMT6
Function histone methyltransferase activity (H3-R2 specific)
Related Protein PRMT6
Function histone methyltransferase activity (H4-R3 specific)
Related Protein PRMT7; PRMT8B; PRMT6; PRMT8; PRMT1
Function histone-arginine N-methyltransferase activity
Related Protein PRMT5; PRMT8; CARM1; PRMT3; PRMT7; PRMT2; PRMT6
Function protein binding
Related Protein DAP3; GATC; TGFBR2; PTRH2; NOS1; ATXN7L3; VTI1B; TBC1D2; ITGA3; LY96
Function protein-arginine omega-N asymmetric methyltransferase activity
Related Protein CARM1; PRMT8; PRMT7; PRMT1; PRMT6; PRMT3; PRMT8B; PRMT2
Function protein-arginine omega-N monomethyltransferase activity
Related Protein PRMT6; PRMT8B; PRMT7; PRMT8

Interacting Protein

PRMT6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRMT6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRMT6.
HMGA1; a8k932_human; s-adenosyl-l-methionine-1; HMGA2; PSMD11; DNALI1; SMAD9