Recombinant Human PRMT6 Protein, His-tagged

• Cat.No.: PRMT6-044H
• Product Overview: Recombinant N-terminal His-tagged human PRMT6 protein was expressed in Sf21 cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Description: The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity.
• Molecular Mass: 43.7 kDa
• Purity: ≥60%
• Stability: ≥ 2 years
• Storage: At -80 centigrade.
• Storage Buffer: 50 mM Tris-HCl, pH 8.0, containing 150 mM sodium chloride, and 20% glycerol

Gene Information

• Gene Name: PRMT6 protein arginine methyltransferase 6 [ Homo sapiens (human) ]
• Official Symbol: PRMT6
• Synonyms: PRMT6; protein arginine methyltransferase 6; HRMT1L6; protein arginine N-methyltransferase 6; HMT1 hnRNP methyltransferase-like 6; heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6; histone-arginine N-methyltransferase PRMT6; EC 2.1.1.319
• Gene ID: 55170
• mRNA Refseq: NM_018137
• Protein Refseq: NP_060607
• MIM: 608274
• UniProt ID: Q96LA8