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PRMT8

Official Full Name

protein arginine methyltransferase 8
Overview

Arginine methylation is a widespread posttranslational modification mediated by arginine methyltransferases, such as PRMT8. Arginine methylation is involved in a number of cellular processes, including DNA repair, RNA transcription, signal transduction, protein compartmentalization, and possibly protein translation (Lee et al., 2005 [PubMed 16051612]).[supplied by OMIM, Mar 2008]
Synonyms

PRMT8; protein arginine methyltransferase 8; HRMT1L3; HRMT1L4; protein arginine N-methyltransferase 8; HMT1 hnRNP methyltransferase-like 3; protein arginine N-methyltransferase 4; heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads
Assay Kits

Species

Human
Mouse

Source

E. coli
E.coli
HEK293
HEK293T
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PRMT8-180H	Recombinant Human PRMT8 Protein, His-tagged	E.coli	His	61-394	Inquiry
Human	PRMT8-5043H	Recombinant Human PRMT8 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	PRMT8-2837HCL	Recombinant Human PRMT8 293 Cell Lysate	HEK293	N/A		Inquiry
Human	PRMT8-126H	Recombinant Human PRMT8 Protein, GST-tagged	E. coli	GST		Inquiry
Human	PRMT8-004H	Recombinant Human PRMT8 Protein, GST-tagged	E.coli	GST		Inquiry
Mouse	PRMT8-13422M	Recombinant Mouse PRMT8 Protein	Mammalian Cell	His		Inquiry
Mouse	PRMT8-7128M	Recombinant Mouse PRMT8 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	PRMT8-7128M-B	Recombinant Mouse PRMT8 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	Prmt8-5136M	Recombinant Mouse Prmt8 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
	Kit-1862	PRMT8 Chemiluminescent Assay Kit		N/A		Inquiry
	Kit-1863	PRMT8 Homogeneous Assay Kit		N/A		Inquiry

Involved Pathway
Protein Function
Interacting Protein

PRMT8 involved in several pathways and played different roles in them. We selected most pathways PRMT8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PRMT8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

PRMT8 has several biochemical functions, for example, S-adenosylmethionine-dependent methyltransferase activity, histone methyltransferase activity (H4-R3 specific), histone-arginine N-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRMT8 itself. We selected most functions PRMT8 had, and list some proteins which have the same functions with PRMT8. You can find most of the proteins on our site.

Function	Related Protein
S-adenosylmethionine-dependent methyltransferase activity	TPMT.1;AS3MT;LSM1;C6orf211;PRMT7;MEPCE;RRP8;METTL7A;NOP2
histone methyltransferase activity (H4-R3 specific)	PRMT7;PRMT8B;PRMT1;PRMT8;PRMT6
histone-arginine N-methyltransferase activity	CARM1;PRMT7;PRMT6;PRMT2;PRMT3;PRMT8;PRMT5
identical protein binding	VWA2;TRAF2;RNF4;ALAD;PCM1;THG1L;NLRC4;PSMD4;SLK
protein binding	CEP152;MRPL45;RNF139;IQUB;TAB1;EDC3;KIF14;ANP32B;NCS1
protein heterodimerization activity	TGFB3;KATNA1;DMRT3;HIST1H2BO;CREB3L3;Defa-rs7;IKZF4;ARNT2;ADRa1A
protein homodimerization activity	ATIC;SLC26A5;MAPK4;TP53I3;PVRL2L;RAB11FIP3;FAP;S100A13;ASNS
protein-arginine omega-N asymmetric methyltransferase activity	PRMT2;PRMT8B;PRMT6;PRMT8;CARM1;PRMT1;PRMT3;PRMT7
protein-arginine omega-N monomethyltransferase activity	PRMT8B;PRMT6;PRMT8;PRMT7

PRMT8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRMT8 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRMT8.

SYNCRIP; PRMT1; COIL; VHL; PPARA; DCAF8; CEP162; OFCC1; SERBP1; GPATCH2L; ZNF451