psmd10
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  • Official Full Name
  • proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
  • Background
  • This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.
  • Synonyms
  • PSMD10; proteasome (prosome, macropain) 26S subunit, non-ATPase, 10; 26S proteasome non-ATPase regulatory subunit 10; gankyrin; p28; ankyrin repeat protein; 26S proteasome regulatory subunit p28; hepatocellular carcinoma-associated protein p28-II; p28(GAN
Cat.#:PSMD10-358HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Proteasome (prosome, macropain) 26S Subunit, Non-ATPase, 10
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Cat.#:PSMD10-1502HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PSMD10 protein, His & T7-tagged
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Cat.#:PSMD10-2026HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PSMD10, GST-tagged
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Cat.#:PSMD10-6927HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Proteasome (prosome, macropain) 26S Subunit, Non-ATPase, 10
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Cat.#:PSMD10-4785RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PSMD10 Protein
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Cat.#:PSMD10-3668RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PSMD10 Protein, His-tagged
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Cat.#:PSMD10-5240CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PSMD10
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Cat.#:PSMD10-11769ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PSMD10
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Cat.#:PSMD10-2755HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PSMD10 293 Cell Lysate
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Cat.#:PSMD10-2756HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PSMD10 293 Cell Lysate
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Involved Pathway

PSMD10 involved in several pathways and played different roles in them. We selected most pathways PSMD10 participated on our site, such as APC/C-mediated degradation of cell cycle proteins, APC/C:Cdc20 mediated degradation of Securin, APC/C:Cdc20 mediated degradation of mitotic proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMD10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
APC/C-mediated degradation of cell cycle proteins
NEK2; AURKB; CDK2; ANAPC10; PSMD10; UBE2C; PSME3; PSMD5; PSMD9; PSMA8
APC/C:Cdc20 mediated degradation of Securin
PSMD14; ANAPC10; PSMD9; UBE2C; PSMD5; PSMD10; PSME3; PSMA8
APC/C:Cdc20 mediated degradation of mitotic proteins
ANAPC10; PSMD9; PSMD10; PSMD5; PSMD14; NEK2; PSME3; UBE2C; PSMA8
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
PSME3; ANAPC10; UBE2C; PSMA8; PSMD5; PSMD14; PSMD9; AURKB; PSMD10
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
PSMD10; NEK2; PSMD14; PSMA8; PSMD9; PSME3; ANAPC10; PSMD5; UBE2C
ARMS-mediated activation
PTPRA; CSF2; WDR83; SPNA1; PSMD5; PHB; RASGRP4; DUSP7; LAMTOR2; PSME3
AUF1 (hnRNP D0) binds and destabilizes mRNA
PSMD5; PSMD10; PSMD14; PSME3; HNRNPD; EIF4G1; PSMA8; PSMD9
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
UBE2C; NEK2; PSME3; ANAPC10; PSMD5; PSMD10; PSMD14; PSMD9; PSMA8

Protein Function

PSMD10 has several biochemical functions, for example, protein binding, transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMD10 itself. We selected most functions PSMD10 had, and list some proteins which have the same functions with PSMD10. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein RECQL4; PTEN; SLIRP; KRT86; KCNA5; PBRM1; LSM4; PLK1S1; FCN2; KLHL12
Function transcription factor binding
Related Protein GATA4; PPP1R13BA; HES6; ZFPM1; HES3; RBL1; KAT8; MED12L; NEUROD1; PITX2

Interacting Protein

PSMD10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMD10 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMD10.
PSMC4; PSMC1; PSMD7