Recombinant Human Proteasome (prosome, macropain) 26S Subunit, Non-ATPase, 10

• Cat.No.: PSMD10-358H
• Product Overview: Recombinant human PSMD10 was expressed in E.coli and purified by conventional chromatography techniques, 24.4kDa (226aa).

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: PSMD10 is an oncoprotein commonly overexpressed in most hepatocellular carcinomas. Gankyrin interacts with S6 ATPase of the 19S regulatory particle of the 26S proteasome. It is known to play a role in the regulation of the phosphorylation of the retinoblastoma protein by CDK4, and to enhance the ubiquitinylation of p53 by MDM2. Gankyrin consists of 7 ankyrin repeats and is structurally similar to I kappa Bs.
• Form: Liquid. In Phosphate buffered saline (pH7.4), 10% glycerol
• Purity: > 95% by SDS - PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay)
• Sequences of amino acids: MEGCVSNLMV CNLAYSGKLE ELKESILADK SLATRTDQDS RTALHWACSA GHTEIVEFLL QLGVPVNDKD DAGWSPLHIA ASAGRDEIVK ALLGKGAQVN AVNQNGCTPL HYAASKNRHE IAVMLLEGGA NPDAKDHYEA TAMHRAAAKG NLKMIHILLY YKASTNIQDT EGNTPLHLAC DEERVEEAKL LVSQGASIYI ENKEEKTPLQ VAKGGLGLIL KRMVEG
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 [ Homo sapiens ]
• Synonyms: Gankyrin; OTTHUMP00000023827; OTTHUMP00000023828; dJ889N15.2; gankyrin; p28; 26S proteasome regulatory subunit p28; ankyrin repeat protein; hepatocellular carcinoma-associated protein p28-II; proteasome (prosome, macropain) 26S subunit, non-ATPase, 10; proteasome 26S non-ATPase subunit 10; PSMD10; 26S proteasome non-ATPase regulatory subunit 10.
• Gene ID: 5716
• mRNA Refseq: NM_002814
• Protein Refseq: NP_002805
• MIM: 603480
• UniProt ID: O75832
• Chromosome Location: Xq22.3
• Function: protein binding