PSMD12 Protein, proteasome (prosome, macropain) 26S subunit, non-ATPase, 12


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Official Full Name proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
Background The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3.
Synonyms PSMD12; proteasome (prosome, macropain) 26S subunit, non-ATPase, 12; 26S proteasome non-ATPase regulatory subunit 12; p55; Rpn5; 26S proteasome regulatory subunit p55; 26S proteasome regulatory subunit RPN5; MGC75406; proteasome (prosome, macropain) 26S subunit, non ATPase12; Proteasome 26S non ATPase subunit 12 isoform 2; PSD12_HUMAN
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PSMD12-2028H Recombinant Human PSMD12, GST-tagged E.coli GST
    Human PSMD12-2753HCL Recombinant Human PSMD12 293 Cell Lysate HEK293 N/A
    Mouse PSMD12-13590M Recombinant Mouse PSMD12 Protein Mammalian Cell His
    Rhesus Macaque PSMD12-3669R Recombinant Rhesus monkey PSMD12 Protein, His-tagged Mammalian Cell His
    Chicken PSMD12-2408C Recombinant Chicken PSMD12 Mammalian Cell His
    Zebrafish PSMD12-11560Z Recombinant Zebrafish PSMD12 Mammalian Cell His

    PSMD12 involved in several pathways and played different roles in them. We selected most pathways PSMD12 participated on our site, such as Proteasome, Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMD12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Proteasome PSMC2; PSMD11; PSMB4; PSMD4B; PSMB5; PSMD2; PSMA7; PSMA4; PSMA1; PSMC6
    Epstein-Barr virus infection HLA-C; ENTPD1; HLA-G; GSK3B; TYK2; TRAF1; PRKACB; MAPK10; EP300; HSPA6

    PSMD12 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by PSMD12 itself. We selected most functions PSMD12 had, and list some proteins which have the same functions with PSMD12. You can find most of the proteins on our site.

    Function Related Protein

    PSMD12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMD12 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMD12.


    Wang, T; Jiang, X; et al. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. NEUROBIOLOGY OF AGING 36:527-535(2015).
    Kim, HY; Byun, MJ; et al. A replication study of genome-wide CNV association for hepatic biomarkers identifies nine genes associated with liver function. BMB REPORTS 44:578-583(2011).

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