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Official Full Name proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
Background The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified.
Synonyms PSME1; proteasome (prosome, macropain) activator subunit 1 (PA28 alpha); proteasome activator complex subunit 1; IFI5111; PA28alpha; 11S regulator complex alpha subunit; 29kD MCP activator subunit; Activator of multicatalytic protease subunit 1; Interferon gamma IEF SSP 5111; Interferon gamma inducible protein 5111; Interferon gamma up regulated I 5111 protein; MGC8628; PA28A; Proteasome activator subunit 1; REGalpha; REG-alpha; IGUP I-5111; 29-kD MCP activator subunit; interferon-gamma IEF SSP 5111; proteasome activator subunit-1; 11S regulator complex subunit alpha; proteasome activator 28 subunit alpha; interferon-gamma-inducible protein 5111; interferon gamma up-regulated I-5111 protein
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PSME1-2742HCL Recombinant Human PSME1 293 Cell Lysate HEK293 N/A
    Human PSME1-2833H Recombinant Human PSME1, His-tagged E.coli His
    Human PSME1-31227TH Recombinant Human PSME1, His-tagged E.coli His
    Human PSME1-361H Recombinant Human PSME1, His tagged E.coli GST
    Mouse PSME1-13601M Recombinant Mouse PSME1 Protein Mammalian Cell His
    Rat Psme1-708R Recombinant Rat Psme1 E.coli N/A
    Cynomolgus Monkey PSME1-826C Recombinant Cynomolgus PSME1 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque PSME1-3675R Recombinant Rhesus monkey PSME1 Protein, His-tagged Mammalian Cell His
    Zebrafish PSME1-8952Z Recombinant Zebrafish PSME1 Mammalian Cell His

    PSME1 involved in several pathways and played different roles in them. We selected most pathways PSME1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSME1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Proteasome PSME1; PSMD13; PSMB11; PSMB9A; PSMA5; PSME2; PSMC2; SHFM1; PSMD4B; PSMC5
    Antigen processing and presentation HSPA2; CTSB; CTSL1; HLA-DQA1; IFNG; HLA-DQA2; KIR2DL3; KIR3DL2; PSME1; HLA-DQB1

    PSME1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by PSME1 itself. We selected most functions PSME1 had, and list some proteins which have the same functions with PSME1. You can find most of the proteins on our site.

    Function Related Protein
    endopeptidase activator activity PSME3; SFRP2; PSMD14; ADRM1; PSME1; PSME2

    PSME1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSME1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSME1.


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